Frailty does not affect prognostic markers in patients with acute coronary syndrome: results from a Brazilian university hospital
Objective: To evaluate frailty and its relationship with prognostic markers in hospitalized patients with acute coronary syndrome. Methods: This cross-sectional study with a prospective variable analysis (prognostic markers) involved adults of both sexes aged ≥ 50 years with acute coronary syndrome....
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| Format: | Article |
| Language: | English |
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Brazilian Society of Geriatrics and Gerontology
2024-04-01
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| Series: | Geriatrics, Gerontology and Aging |
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| Online Access: | https://ggaging.com/details/1822/en-US/frailty-does-not-affect-prognostic-markers-in-patients-with-acute-coronary-syndrome--results-from-a-brazilian-university-hospital |
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| author | Maria Eduarda de Paiva Silva Yasminn Luana Costa Alves Camila Ferreira Leal Nunes Wenize Suyane Lopes Fortunato Jarson Pedro da Costa Pereira Cl�udia Porto Sabino Pinho |
| author_facet | Maria Eduarda de Paiva Silva Yasminn Luana Costa Alves Camila Ferreira Leal Nunes Wenize Suyane Lopes Fortunato Jarson Pedro da Costa Pereira Cl�udia Porto Sabino Pinho |
| author_sort | Maria Eduarda de Paiva Silva |
| collection | DOAJ |
| description | Objective: To evaluate frailty and its relationship with prognostic markers in hospitalized patients with acute coronary syndrome. Methods: This cross-sectional study with a prospective variable analysis (prognostic markers) involved adults of both sexes aged ≥ 50 years with acute coronary syndrome. Patients with ≥ 3 of the following criteria wereconsidered frail: 1) unintentional weight loss; 2) exhaustion (assessed by self-reported fatigue); 3) low handgrip strength; 4) low physical activity level; and 5) low gait speed. The included prognostic markers were: metabolic changes (lipid and glycemic profile), changes in inflammatory status (C-reactive protein), thrombolysis in myocardial infarction risk score, troponin level, angioplasty or surgery, hospitalization in the intensive care unit, length of hospital stay, and hospital outcome. Results: The sample consisted of 125 patients, whose mean agewas 65.5 (SD, 8.7) years. The prevalence of frailty was 48.00%, which was higher in women (PR = 1.55; 95%CI 1.08-2.22; p = 0.018) and patients with systemic arterial hypertension (PR = 2.18; 95%CI 1.01-5.24; p = 0.030). Frailty was not associated with age, cardiac diagnosis, or prognostic markers (p > 0.05). Conclusions: Frailty was highly prevalent in patients with acutecoronary syndrome, affecting almost half of the sample, particularly women and patients with hypertension, irrespective of age. However, despite its high prevalence, frailty was not associated with markers of metabolic change or poor prognosis. |
| first_indexed | 2024-04-24T11:25:40Z |
| format | Article |
| id | doaj.art-71cbb34be9fc415bb363eb73777c805f |
| institution | Directory Open Access Journal |
| issn | 2447-2123 |
| language | English |
| last_indexed | 2024-04-24T11:25:40Z |
| publishDate | 2024-04-01 |
| publisher | Brazilian Society of Geriatrics and Gerontology |
| record_format | Article |
| series | Geriatrics, Gerontology and Aging |
| spelling | doaj.art-71cbb34be9fc415bb363eb73777c805f2024-04-10T16:55:11ZengBrazilian Society of Geriatrics and GerontologyGeriatrics, Gerontology and Aging2447-21232024-04-01181810.53886/gga.e0000061_ENFrailty does not affect prognostic markers in patients with acute coronary syndrome: results from a Brazilian university hospitalMaria Eduarda de Paiva Silva0https://orcid.org/0009-0000-7096-8031Yasminn Luana Costa Alves1https://orcid.org/0000-0001-5698-967XCamila Ferreira Leal Nunes2https://orcid.org/0000-0002-1306-7883Wenize Suyane Lopes Fortunato3https://orcid.org/0009-0009-2845-2053Jarson Pedro da Costa Pereira4https://orcid.org/0000-0001-5412-6467Cl�udia Porto Sabino Pinho5https://orcid.org/0000-0002-5689-5048Unidade de Cardiologia de Emergência, Universidade de Pernambuco - Recife, PE, Brazil, Brazil.Unidade de Cardiologia de Emergência, Universidade de Pernambuco - Recife, PE, Brazil, Brazil.Unidade de Cardiologia de Emergência, Universidade de Pernambuco - Recife, PE, Brazil, Brazil.Unidade de Cardiologia de Emergência, Universidade de Pernambuco - Recife, PE, Brazil, Brazil.Departamento de Nutrição, Universidade Federal de Pernambuco - Recife, PE, Brazil, Brazil.Unidade de Cardiologia de Emergência, Universidade de Pernambuco - Recife, PE, Brazil, Brazil.Objective: To evaluate frailty and its relationship with prognostic markers in hospitalized patients with acute coronary syndrome. Methods: This cross-sectional study with a prospective variable analysis (prognostic markers) involved adults of both sexes aged ≥ 50 years with acute coronary syndrome. Patients with ≥ 3 of the following criteria wereconsidered frail: 1) unintentional weight loss; 2) exhaustion (assessed by self-reported fatigue); 3) low handgrip strength; 4) low physical activity level; and 5) low gait speed. The included prognostic markers were: metabolic changes (lipid and glycemic profile), changes in inflammatory status (C-reactive protein), thrombolysis in myocardial infarction risk score, troponin level, angioplasty or surgery, hospitalization in the intensive care unit, length of hospital stay, and hospital outcome. Results: The sample consisted of 125 patients, whose mean agewas 65.5 (SD, 8.7) years. The prevalence of frailty was 48.00%, which was higher in women (PR = 1.55; 95%CI 1.08-2.22; p = 0.018) and patients with systemic arterial hypertension (PR = 2.18; 95%CI 1.01-5.24; p = 0.030). Frailty was not associated with age, cardiac diagnosis, or prognostic markers (p > 0.05). Conclusions: Frailty was highly prevalent in patients with acutecoronary syndrome, affecting almost half of the sample, particularly women and patients with hypertension, irrespective of age. However, despite its high prevalence, frailty was not associated with markers of metabolic change or poor prognosis.https://ggaging.com/details/1822/en-US/frailty-does-not-affect-prognostic-markers-in-patients-with-acute-coronary-syndrome--results-from-a-brazilian-university-hospitalfrailtyacute coronary syndromeprognosis |
| spellingShingle | Maria Eduarda de Paiva Silva Yasminn Luana Costa Alves Camila Ferreira Leal Nunes Wenize Suyane Lopes Fortunato Jarson Pedro da Costa Pereira Cl�udia Porto Sabino Pinho Frailty does not affect prognostic markers in patients with acute coronary syndrome: results from a Brazilian university hospital Geriatrics, Gerontology and Aging frailty acute coronary syndrome prognosis |
| title | Frailty does not affect prognostic markers in patients with acute coronary syndrome: results from a Brazilian university hospital |
| title_full | Frailty does not affect prognostic markers in patients with acute coronary syndrome: results from a Brazilian university hospital |
| title_fullStr | Frailty does not affect prognostic markers in patients with acute coronary syndrome: results from a Brazilian university hospital |
| title_full_unstemmed | Frailty does not affect prognostic markers in patients with acute coronary syndrome: results from a Brazilian university hospital |
| title_short | Frailty does not affect prognostic markers in patients with acute coronary syndrome: results from a Brazilian university hospital |
| title_sort | frailty does not affect prognostic markers in patients with acute coronary syndrome results from a brazilian university hospital |
| topic | frailty acute coronary syndrome prognosis |
| url | https://ggaging.com/details/1822/en-US/frailty-does-not-affect-prognostic-markers-in-patients-with-acute-coronary-syndrome--results-from-a-brazilian-university-hospital |
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