Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms
Abstract A straightforward and efficient spectrum technique was created using Ortho-chloranil as the electron acceptor (-acceptor) in a charge transfer (CT) complex formation reaction to determine the concentration of famotidine (FMD) in solutions. Compared to the double-distilled blank solution, th...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-54402-4 |
| _version_ | 1797274871139401728 |
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| author | Shatha Y. Al Samarrai Radhi AlZubaidi Nadhir Al-Ansari |
| author_facet | Shatha Y. Al Samarrai Radhi AlZubaidi Nadhir Al-Ansari |
| author_sort | Shatha Y. Al Samarrai |
| collection | DOAJ |
| description | Abstract A straightforward and efficient spectrum technique was created using Ortho-chloranil as the electron acceptor (-acceptor) in a charge transfer (CT) complex formation reaction to determine the concentration of famotidine (FMD) in solutions. Compared to the double-distilled blank solution, the reaction result detected a definite violet colour at a maximum absorption wavelength of 546 nm, For concentrations range 2—28 µg/ml, the technique demonstrated excellent compliance with Beer-Law and Lambert's, as evidenced by its molar absorptivity of 2159.648 L mol−1 cm–1. Lower detection limits of 0.3024 µg/ml and 1.471 µg/ml, respectively, were discovered. The complexes of famotidine and Ortho-chloranil were found to have a 2:1 stoichiometry. Additionally, the suggested approach effectively estimated famotidine concentrations in pharmaceutical formulations, particularly in tablet form. |
| first_indexed | 2024-03-07T15:04:20Z |
| format | Article |
| id | doaj.art-71ccbc47c11d4c86b07ad3246f8d5dd7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:04:20Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-71ccbc47c11d4c86b07ad3246f8d5dd72024-03-05T18:57:01ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-54402-4Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage formsShatha Y. Al Samarrai0Radhi AlZubaidi1Nadhir Al-Ansari2Chemistry Department, College of Science, Tikrit UniversityCivil and Environmental Engineering, College of Engineering, University of SharjahDepartment of Civil, Environmental and Natural Resources Engineering, Lulea University of TechnologyAbstract A straightforward and efficient spectrum technique was created using Ortho-chloranil as the electron acceptor (-acceptor) in a charge transfer (CT) complex formation reaction to determine the concentration of famotidine (FMD) in solutions. Compared to the double-distilled blank solution, the reaction result detected a definite violet colour at a maximum absorption wavelength of 546 nm, For concentrations range 2—28 µg/ml, the technique demonstrated excellent compliance with Beer-Law and Lambert's, as evidenced by its molar absorptivity of 2159.648 L mol−1 cm–1. Lower detection limits of 0.3024 µg/ml and 1.471 µg/ml, respectively, were discovered. The complexes of famotidine and Ortho-chloranil were found to have a 2:1 stoichiometry. Additionally, the suggested approach effectively estimated famotidine concentrations in pharmaceutical formulations, particularly in tablet form.https://doi.org/10.1038/s41598-024-54402-4Charge transfer complexFamotidineOrtho-chloranilSpectrophotometric |
| spellingShingle | Shatha Y. Al Samarrai Radhi AlZubaidi Nadhir Al-Ansari Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms Scientific Reports Charge transfer complex Famotidine Ortho-chloranil Spectrophotometric |
| title | Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms |
| title_full | Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms |
| title_fullStr | Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms |
| title_full_unstemmed | Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms |
| title_short | Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms |
| title_sort | charge transfer complex based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms |
| topic | Charge transfer complex Famotidine Ortho-chloranil Spectrophotometric |
| url | https://doi.org/10.1038/s41598-024-54402-4 |
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