Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice
Gut microbiota composition is altered in patients with alcohol use disorder, and fecal microbiota transplant reduced alcohol craving in patients with alcohol use disorder and liver cirrhosis in a phase 1 clinical trial. Here the authors used stool samples collected in the trial to report that this p...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34054-6 |
| _version_ | 1828218021644075008 |
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| author | Jennifer T. Wolstenholme Justin M. Saunders Maren Smith Jason D. Kang Phillip B. Hylemon Javier González-Maeso Andrew Fagan Derrick Zhao Masoumeh Sikaroodi Jeremy Herzog Amirhossein Shamsaddini Marcela Peña-Rodríguez Lianyong Su Yun-Ling Tai Jing Zheng Po-Cheng Cheng R. Balfour Sartor Patrick M. Gillevet Huiping Zhou Jasmohan S. Bajaj |
| author_facet | Jennifer T. Wolstenholme Justin M. Saunders Maren Smith Jason D. Kang Phillip B. Hylemon Javier González-Maeso Andrew Fagan Derrick Zhao Masoumeh Sikaroodi Jeremy Herzog Amirhossein Shamsaddini Marcela Peña-Rodríguez Lianyong Su Yun-Ling Tai Jing Zheng Po-Cheng Cheng R. Balfour Sartor Patrick M. Gillevet Huiping Zhou Jasmohan S. Bajaj |
| author_sort | Jennifer T. Wolstenholme |
| collection | DOAJ |
| description | Gut microbiota composition is altered in patients with alcohol use disorder, and fecal microbiota transplant reduced alcohol craving in patients with alcohol use disorder and liver cirrhosis in a phase 1 clinical trial. Here the authors used stool samples collected in the trial to report that this phenotype is transmissible via microbial transfer to germ free mice, as assessed by reduced ethanol acceptance, intake and preference. |
| first_indexed | 2024-04-12T15:57:13Z |
| format | Article |
| id | doaj.art-71cd530afe02445e92a5c780310d4264 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T15:57:13Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-71cd530afe02445e92a5c780310d42642022-12-22T03:26:20ZengNature PortfolioNature Communications2041-17232022-10-0113111410.1038/s41467-022-34054-6Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free miceJennifer T. Wolstenholme0Justin M. Saunders1Maren Smith2Jason D. Kang3Phillip B. Hylemon4Javier González-Maeso5Andrew Fagan6Derrick Zhao7Masoumeh Sikaroodi8Jeremy Herzog9Amirhossein Shamsaddini10Marcela Peña-Rodríguez11Lianyong Su12Yun-Ling Tai13Jing Zheng14Po-Cheng Cheng15R. Balfour Sartor16Patrick M. Gillevet17Huiping Zhou18Jasmohan S. Bajaj19VCU-Alcohol Research Center and Department of Pharmacology and Toxicology, Virginia Commonwealth UniversityDepartment of Physiology and Biophysics, Virginia Commonwealth UniversityVCU-Alcohol Research Center and Department of Pharmacology and Toxicology, Virginia Commonwealth UniversityMicrobiology and Immunology, Virginia Commonwealth UniversityDepartment of Physiology and Biophysics, Virginia Commonwealth UniversityDepartment of Physiology and Biophysics, Virginia Commonwealth UniversityDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical CenterMicrobiology and Immunology, Virginia Commonwealth UniversityMicrobiome Analysis Center, George Mason UniversityNational Gnotobiotic Rodent Research Center, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel HillMicrobiome Analysis Center, George Mason UniversityUniversity Center for Health Sciences, University of GuadalajaraMicrobiology and Immunology, Virginia Commonwealth UniversityMicrobiology and Immunology, Virginia Commonwealth UniversityMicrobiology and Immunology, Virginia Commonwealth UniversityMicrobiology and Immunology, Virginia Commonwealth UniversityNational Gnotobiotic Rodent Research Center, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel HillMicrobiome Analysis Center, George Mason UniversityMicrobiology and Immunology, Virginia Commonwealth UniversityDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical CenterGut microbiota composition is altered in patients with alcohol use disorder, and fecal microbiota transplant reduced alcohol craving in patients with alcohol use disorder and liver cirrhosis in a phase 1 clinical trial. Here the authors used stool samples collected in the trial to report that this phenotype is transmissible via microbial transfer to germ free mice, as assessed by reduced ethanol acceptance, intake and preference.https://doi.org/10.1038/s41467-022-34054-6 |
| spellingShingle | Jennifer T. Wolstenholme Justin M. Saunders Maren Smith Jason D. Kang Phillip B. Hylemon Javier González-Maeso Andrew Fagan Derrick Zhao Masoumeh Sikaroodi Jeremy Herzog Amirhossein Shamsaddini Marcela Peña-Rodríguez Lianyong Su Yun-Ling Tai Jing Zheng Po-Cheng Cheng R. Balfour Sartor Patrick M. Gillevet Huiping Zhou Jasmohan S. Bajaj Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice Nature Communications |
| title | Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice |
| title_full | Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice |
| title_fullStr | Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice |
| title_full_unstemmed | Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice |
| title_short | Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice |
| title_sort | reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ free mice |
| url | https://doi.org/10.1038/s41467-022-34054-6 |
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