Risk Polymorphisms of <i>FNDC5</i>, <i>BDNF</i>, and <i>NTRK2</i> and Poor Education Interact and Aggravate Age-Related Cognitive Decline
Cognitive abilities tend to decline with aging, with variation between individuals, and many studies seek to identify genetic biomarkers that more accurately anticipate risks related to pathological aging. We investigated the influence of <i>BDNF</i>, <i>NTRK2</i>, and <i&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/24/17210 |
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| author | Alessandra Mendonça Tomás Natáli Valim Oliver Bento-Torres Naina Yuki Vieira Jardim Patrícia Martins Moraes Victor Oliveira da Costa Antônio Conde Modesto André Salim Khayat João Bento-Torres Cristovam Wanderley Picanço-Diniz |
| author_facet | Alessandra Mendonça Tomás Natáli Valim Oliver Bento-Torres Naina Yuki Vieira Jardim Patrícia Martins Moraes Victor Oliveira da Costa Antônio Conde Modesto André Salim Khayat João Bento-Torres Cristovam Wanderley Picanço-Diniz |
| author_sort | Alessandra Mendonça Tomás |
| collection | DOAJ |
| description | Cognitive abilities tend to decline with aging, with variation between individuals, and many studies seek to identify genetic biomarkers that more accurately anticipate risks related to pathological aging. We investigated the influence of <i>BDNF</i>, <i>NTRK2</i>, and <i>FNDC5</i> single nucleotide polymorphisms (SNPs) on the cognitive performance of young and older adults with contrasting educational backgrounds. We addressed three questions: (1) Is education associated with reduced age-related cognitive decline? (2) Does the presence of SNPs explain the variation in cognitive performance observed late in life? (3) Is education differentially associated with cognition based on the presence of <i>BDNF</i>, <i>NTRK2</i>, or <i>FNDC5</i> polymorphisms? We measured the cognitive functions of young and older participants, with lower and higher education, using specific and sensitive tests of the Cambridge Automated Neuropsychological Test Assessment Battery. A three-way ANOVA revealed that SNPs were associated with differential performances in executive functions, episodic memory, sustained attention, mental and motor response speed, and visual recognition memory and that higher educational levels improved the affected cognitive functions. The results revealed that distinct SNPs affect cognition late in life differentially, suggesting their utility as potential biomarkers and emphasizing the importance of cognitive stimulation that advanced education early in life provides. |
| first_indexed | 2024-03-08T20:41:52Z |
| format | Article |
| id | doaj.art-71cd7f5033a14a0bac2c64964befb1d2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T20:41:52Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-71cd7f5033a14a0bac2c64964befb1d22023-12-22T14:13:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124241721010.3390/ijms242417210Risk Polymorphisms of <i>FNDC5</i>, <i>BDNF</i>, and <i>NTRK2</i> and Poor Education Interact and Aggravate Age-Related Cognitive DeclineAlessandra Mendonça Tomás0Natáli Valim Oliver Bento-Torres1Naina Yuki Vieira Jardim2Patrícia Martins Moraes3Victor Oliveira da Costa4Antônio Conde Modesto5André Salim Khayat6João Bento-Torres7Cristovam Wanderley Picanço-Diniz8Neurodegeneration and Infection Research Laboratory, Institute of Biological Science, João de Barros Barreto University Hospital, Federal University of Pará, Belém 66073-000, BrazilNeurodegeneration and Infection Research Laboratory, Institute of Biological Science, João de Barros Barreto University Hospital, Federal University of Pará, Belém 66073-000, BrazilNeurodegeneration and Infection Research Laboratory, Institute of Biological Science, João de Barros Barreto University Hospital, Federal University of Pará, Belém 66073-000, BrazilNeurodegeneration and Infection Research Laboratory, Institute of Biological Science, João de Barros Barreto University Hospital, Federal University of Pará, Belém 66073-000, BrazilNeurodegeneration and Infection Research Laboratory, Institute of Biological Science, João de Barros Barreto University Hospital, Federal University of Pará, Belém 66073-000, BrazilOncology Research Center (NPO), Graduate Program in Oncology and Medical Sciences, Federal University of Pará, Belém 66073-000, BrazilOncology Research Center (NPO), Graduate Program in Oncology and Medical Sciences, Federal University of Pará, Belém 66073-000, BrazilNeurodegeneration and Infection Research Laboratory, Institute of Biological Science, João de Barros Barreto University Hospital, Federal University of Pará, Belém 66073-000, BrazilNeurodegeneration and Infection Research Laboratory, Institute of Biological Science, João de Barros Barreto University Hospital, Federal University of Pará, Belém 66073-000, BrazilCognitive abilities tend to decline with aging, with variation between individuals, and many studies seek to identify genetic biomarkers that more accurately anticipate risks related to pathological aging. We investigated the influence of <i>BDNF</i>, <i>NTRK2</i>, and <i>FNDC5</i> single nucleotide polymorphisms (SNPs) on the cognitive performance of young and older adults with contrasting educational backgrounds. We addressed three questions: (1) Is education associated with reduced age-related cognitive decline? (2) Does the presence of SNPs explain the variation in cognitive performance observed late in life? (3) Is education differentially associated with cognition based on the presence of <i>BDNF</i>, <i>NTRK2</i>, or <i>FNDC5</i> polymorphisms? We measured the cognitive functions of young and older participants, with lower and higher education, using specific and sensitive tests of the Cambridge Automated Neuropsychological Test Assessment Battery. A three-way ANOVA revealed that SNPs were associated with differential performances in executive functions, episodic memory, sustained attention, mental and motor response speed, and visual recognition memory and that higher educational levels improved the affected cognitive functions. The results revealed that distinct SNPs affect cognition late in life differentially, suggesting their utility as potential biomarkers and emphasizing the importance of cognitive stimulation that advanced education early in life provides.https://www.mdpi.com/1422-0067/24/24/17210risk factorseducationagingpolymorphismgeneticcognition |
| spellingShingle | Alessandra Mendonça Tomás Natáli Valim Oliver Bento-Torres Naina Yuki Vieira Jardim Patrícia Martins Moraes Victor Oliveira da Costa Antônio Conde Modesto André Salim Khayat João Bento-Torres Cristovam Wanderley Picanço-Diniz Risk Polymorphisms of <i>FNDC5</i>, <i>BDNF</i>, and <i>NTRK2</i> and Poor Education Interact and Aggravate Age-Related Cognitive Decline International Journal of Molecular Sciences risk factors education aging polymorphism genetic cognition |
| title | Risk Polymorphisms of <i>FNDC5</i>, <i>BDNF</i>, and <i>NTRK2</i> and Poor Education Interact and Aggravate Age-Related Cognitive Decline |
| title_full | Risk Polymorphisms of <i>FNDC5</i>, <i>BDNF</i>, and <i>NTRK2</i> and Poor Education Interact and Aggravate Age-Related Cognitive Decline |
| title_fullStr | Risk Polymorphisms of <i>FNDC5</i>, <i>BDNF</i>, and <i>NTRK2</i> and Poor Education Interact and Aggravate Age-Related Cognitive Decline |
| title_full_unstemmed | Risk Polymorphisms of <i>FNDC5</i>, <i>BDNF</i>, and <i>NTRK2</i> and Poor Education Interact and Aggravate Age-Related Cognitive Decline |
| title_short | Risk Polymorphisms of <i>FNDC5</i>, <i>BDNF</i>, and <i>NTRK2</i> and Poor Education Interact and Aggravate Age-Related Cognitive Decline |
| title_sort | risk polymorphisms of i fndc5 i i bdnf i and i ntrk2 i and poor education interact and aggravate age related cognitive decline |
| topic | risk factors education aging polymorphism genetic cognition |
| url | https://www.mdpi.com/1422-0067/24/24/17210 |
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