Inhibition of Col6a5 Improve Lipid Metabolism Disorder in Dihydrotestosterone-Induced Hyperandrogenic Mice

Inhibition of Col6a5 Improve Lipid Metabolism Disorder in Dihydrotestosterone-Induced Hyperandrogenic Mice

Hyperandrogenism is a key pathological feature of polycystic ovarian syndrome (PCOS). Excess androgen can lead to PCOS-like cell hypertrophy in the ovaries and adipose tissue of rodents. Here, we established a dihydrotestosterone (DHT)-induced hyperandrogenic mouse model to analyze the differences i...

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Bibliographic Details
Main Authors: Li-Feng Sun, Ya-Li Yang, Mei-Yue Wang, Hua-Shan Zhao, Tian-xia Xiao, Meng-Xia Li, Bao-Bei Wang, Chen Huang, Pei-Gen Ren, Jian V. Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
dihydrotestosterone
ovary
gonad fat
Col6a5
hypertrophy
lipid metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.669189/full

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