Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines
The objective of this work was to advance implantable Ruthenium complexes incorporated polycaprolactone (PCL-Ru) electrospun nanofibers, which might hold great potential for cancer diagnosis. Ruthenium complex was infused into biodegradable PCL nanofibers by the electrospinning method and was charac...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622000996 |
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| author | Siranjeevi Ravichandran Jeyalakshmi Radhakrishnan Vanaitha Nandhiraman Mariappan Mariappan |
| author_facet | Siranjeevi Ravichandran Jeyalakshmi Radhakrishnan Vanaitha Nandhiraman Mariappan Mariappan |
| author_sort | Siranjeevi Ravichandran |
| collection | DOAJ |
| description | The objective of this work was to advance implantable Ruthenium complexes incorporated polycaprolactone (PCL-Ru) electrospun nanofibers, which might hold great potential for cancer diagnosis. Ruthenium complex was infused into biodegradable PCL nanofibers by the electrospinning method and was characterized for their structural and surface morphology using FESEM, HRTEM, and XRD. The chemical analysis was performed through FTIR and UV–Vis. The mechanical strength and thermal behavior of the electrospun nanofibrous have been examined in this study. The average diameter of pristine PCL and PCL-Ru nanofibers was 617.91 ± 165 nm and 426.77 ± 14 nm. The in vitro anticancer activity of Ru-complexes infused PCL nanofibers was assessed against liver (Hep-G2), oral cancer (HSC-3), renal cell carcinomas (ACHN), and lung (L-132) cancer cell lines, as well as the release profile of the Ru-complexes, infused PCL nanofibers. According to the results, Ru-complexes containing PCL may be easily infused into nanofibers and have a very uniform distribution inside them. More significantly, the Ru-complexes produced by the blended nanofibers can be released for an extended of period time, resulting in significant anticancer efficacy in vitro. |
| first_indexed | 2024-04-11T12:47:30Z |
| format | Article |
| id | doaj.art-71cf230ed8314b06a7e7bc6eb28039d8 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-11T12:47:30Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-71cf230ed8314b06a7e7bc6eb28039d82022-12-22T04:23:19ZengElsevierResults in Chemistry2211-71562022-01-014100380Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell linesSiranjeevi Ravichandran0Jeyalakshmi Radhakrishnan1Vanaitha Nandhiraman2Mariappan Mariappan3Department of Chemistry, SRM Institute of Science and Technology (SRMIST), Kattankulathur- 603 203, Kancheepuram (DT), Tamil Nadu, India; Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602 105, Tamil Nadu, IndiaDepartment of Chemistry, SRM Institute of Science and Technology (SRMIST), Kattankulathur- 603 203, Kancheepuram (DT), Tamil Nadu, India; Corresponding author.Department of Chemistry, SRM Institute of Science and Technology (SRMIST), Kattankulathur- 603 203, Kancheepuram (DT), Tamil Nadu, IndiaDepartment of Chemistry, SRM Institute of Science and Technology (SRMIST), Kattankulathur- 603 203, Kancheepuram (DT), Tamil Nadu, IndiaThe objective of this work was to advance implantable Ruthenium complexes incorporated polycaprolactone (PCL-Ru) electrospun nanofibers, which might hold great potential for cancer diagnosis. Ruthenium complex was infused into biodegradable PCL nanofibers by the electrospinning method and was characterized for their structural and surface morphology using FESEM, HRTEM, and XRD. The chemical analysis was performed through FTIR and UV–Vis. The mechanical strength and thermal behavior of the electrospun nanofibrous have been examined in this study. The average diameter of pristine PCL and PCL-Ru nanofibers was 617.91 ± 165 nm and 426.77 ± 14 nm. The in vitro anticancer activity of Ru-complexes infused PCL nanofibers was assessed against liver (Hep-G2), oral cancer (HSC-3), renal cell carcinomas (ACHN), and lung (L-132) cancer cell lines, as well as the release profile of the Ru-complexes, infused PCL nanofibers. According to the results, Ru-complexes containing PCL may be easily infused into nanofibers and have a very uniform distribution inside them. More significantly, the Ru-complexes produced by the blended nanofibers can be released for an extended of period time, resulting in significant anticancer efficacy in vitro.http://www.sciencedirect.com/science/article/pii/S2211715622000996Ruthenium complexesElectrospinningPolycaprolactoneAnticancer activity |
| spellingShingle | Siranjeevi Ravichandran Jeyalakshmi Radhakrishnan Vanaitha Nandhiraman Mariappan Mariappan Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines Results in Chemistry Ruthenium complexes Electrospinning Polycaprolactone Anticancer activity |
| title | Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines |
| title_full | Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines |
| title_fullStr | Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines |
| title_full_unstemmed | Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines |
| title_short | Ruthenium complex infused polycaprolactone (PCL-Ru) nanofibers and their in vitro anticancer activity against human tested cancer cell lines |
| title_sort | ruthenium complex infused polycaprolactone pcl ru nanofibers and their in vitro anticancer activity against human tested cancer cell lines |
| topic | Ruthenium complexes Electrospinning Polycaprolactone Anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622000996 |
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