Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in Rats
Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice and has anti-oxidant and cell-protective effects in animals and humans body. Objective: The aim of this study was to investigate the influence of Ginger rhizome toxicity of Gentamic...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2010-09-01
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| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-271-en.html |
| _version_ | 1818725921514848256 |
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| author | A Zahedi A Khaki HR Ahmadi-Ashtiani H Rastegar Sh Rezazadeh |
| author_facet | A Zahedi A Khaki HR Ahmadi-Ashtiani H Rastegar Sh Rezazadeh |
| author_sort | A Zahedi |
| collection | DOAJ |
| description | Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice and has anti-oxidant and cell-protective effects in animals and humans body. Objective: The aim of this study was to investigate the influence of Ginger rhizome toxicity of Gentamicin on sperm parameters in male rats. Methods: Forty Wistar male rat (n=40) were allocated into four groups, control (n=10) and test groups (n=30), that subdivided into groups of 3 that received ginger rhizome powder (100 mg/kg/day), gentamicin group that received, 5 mg/kg/day and ginger group that received, 5 mg/kg/day gentamicin additionally, for 30 consequence day. Animals were kept in standard conditions. In thirty day the testes tissue of Rats in whole groups were collected. Results: Ginger administration caused a marked increase in the testosterone concentrations of the rats even in spite of receiving 5 mg/kg/day gentamicin in compared with the control and gentamicin treated groups. Conclusion: Ginger rhizome is able to overcome reproductive toxicity of gentamicin and induces spermatogenesis probably mainly through the elevation of testosterone levels. |
| first_indexed | 2024-12-17T21:49:59Z |
| format | Article |
| id | doaj.art-71cfcdeca5324f44bc0baefac3f3bd0e |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-17T21:49:59Z |
| publishDate | 2010-09-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-71cfcdeca5324f44bc0baefac3f3bd0e2022-12-21T21:31:20ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582010-09-019359398Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in RatsA Zahedi0A Khaki1HR Ahmadi-Ashtiani2H Rastegar3Sh Rezazadeh4 Faculty of Veterinary Medicine, Islamic Azad University, Rasht Branch Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch Biochemistry and Nutrition Department of Zanjan University of Medical Sciences, Zanjan, Iran & Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University Ministry of Health and Medical Education, Food & Drug Laboratory Research Center Institute of Medicinal Plants, ACECR Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice and has anti-oxidant and cell-protective effects in animals and humans body. Objective: The aim of this study was to investigate the influence of Ginger rhizome toxicity of Gentamicin on sperm parameters in male rats. Methods: Forty Wistar male rat (n=40) were allocated into four groups, control (n=10) and test groups (n=30), that subdivided into groups of 3 that received ginger rhizome powder (100 mg/kg/day), gentamicin group that received, 5 mg/kg/day and ginger group that received, 5 mg/kg/day gentamicin additionally, for 30 consequence day. Animals were kept in standard conditions. In thirty day the testes tissue of Rats in whole groups were collected. Results: Ginger administration caused a marked increase in the testosterone concentrations of the rats even in spite of receiving 5 mg/kg/day gentamicin in compared with the control and gentamicin treated groups. Conclusion: Ginger rhizome is able to overcome reproductive toxicity of gentamicin and induces spermatogenesis probably mainly through the elevation of testosterone levels.http://jmp.ir/article-1-271-en.htmlginger rhizomemale fertilitytestosteronetoxicity |
| spellingShingle | A Zahedi A Khaki HR Ahmadi-Ashtiani H Rastegar Sh Rezazadeh Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in Rats Journal of Medicinal Plants ginger rhizome male fertility testosterone toxicity |
| title | Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in Rats |
| title_full | Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in Rats |
| title_fullStr | Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in Rats |
| title_full_unstemmed | Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in Rats |
| title_short | Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in Rats |
| title_sort | zingiber officinale protective effects on gentamicin s toxicity on sperm in rats |
| topic | ginger rhizome male fertility testosterone toxicity |
| url | http://jmp.ir/article-1-271-en.html |
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