| Summary: | Nanotechnology provides promising possibilities for several biomedical and pharmaceutical applications in the medicine industry. Nanostructures play a major role in the recent strategies of technology suitable for novel drug applications. In this work, clindamycin phosphate (CliP) (topical anti-inflammatory drug), xanthan gum (XaG) (biopolymer) and ZnO (zinc oxide) (nanoparticle) nanostructures were synthesised using the sonochemical technique at room temperature. The characterization of the clindamycin phosphate- xanthan gum/ZnO (CliP-XaG/ZnO) nanostructure has been carried out by Fourier transform infrared (FTIR) and X-ray diffraction (XRD). The spectroscopic experiments elucidated in vitro the mechanism of drug delivery system at different pH media (1.2 and 7.4). In this study, the concentration of drug in the solution was analyzed by UV–vis spectroscopy method and several kinetic models and error analysis were calculated to prove a connection with results. The Higuchi model had the best correlation parameters. The percentage of swelling ratio (%) reached up 105% in XaG (pH 1.2) and 190% in XaG/ZnO (pH 1.2) And the swelling ratio (%) reached up 530% within in XaG (pH 7.4) and 655% within in XaG/ZnO (pH 7.4). The results show that the capacity of XaG / ZnO can be preferred as a novel topical anti-inflammatory drug carrier.
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