The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis.
Social anxiety disorder is one of the most persistent and common anxiety disorders. Individually delivered psychological therapies are the most effective treatment options for adults with social anxiety disorder, but they are associated with high intervention costs. Therefore, the objective of this...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4624770?pdf=render |
| _version_ | 1828379509147041792 |
|---|---|
| author | Ifigeneia Mavranezouli Evan Mayo-Wilson Sofia Dias Kayleigh Kew David M Clark A E Ades Stephen Pilling |
| author_facet | Ifigeneia Mavranezouli Evan Mayo-Wilson Sofia Dias Kayleigh Kew David M Clark A E Ades Stephen Pilling |
| author_sort | Ifigeneia Mavranezouli |
| collection | DOAJ |
| description | Social anxiety disorder is one of the most persistent and common anxiety disorders. Individually delivered psychological therapies are the most effective treatment options for adults with social anxiety disorder, but they are associated with high intervention costs. Therefore, the objective of this study was to assess the relative cost effectiveness of a variety of psychological and pharmacological interventions for adults with social anxiety disorder.A decision-analytic model was constructed to compare costs and quality adjusted life years (QALYs) of 28 interventions for social anxiety disorder from the perspective of the British National Health Service and personal social services. Efficacy data were derived from a systematic review and network meta-analysis. Other model input parameters were based on published literature and national sources, supplemented by expert opinion.Individual cognitive therapy was the most cost-effective intervention for adults with social anxiety disorder, followed by generic individual cognitive behavioural therapy (CBT), phenelzine and book-based self-help without support. Other drugs, group-based psychological interventions and other individually delivered psychological interventions were less cost-effective. Results were influenced by limited evidence suggesting superiority of psychological interventions over drugs in retaining long-term effects. The analysis did not take into account side effects of drugs.Various forms of individually delivered CBT appear to be the most cost-effective options for the treatment of adults with social anxiety disorder. Consideration of side effects of drugs would only strengthen this conclusion, as it would improve even further the cost effectiveness of individually delivered CBT relative to phenelzine, which was the next most cost-effective option, due to the serious side effects associated with phenelzine. Further research needs to determine more accurately the long-term comparative benefits and harms of psychological and pharmacological interventions for social anxiety disorder and establish their relative cost effectiveness with greater certainty. |
| first_indexed | 2024-12-10T03:42:05Z |
| format | Article |
| id | doaj.art-71d236ad2dae4d33b03734956e1a2900 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T03:42:05Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-71d236ad2dae4d33b03734956e1a29002022-12-22T02:03:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014070410.1371/journal.pone.0140704The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis.Ifigeneia MavranezouliEvan Mayo-WilsonSofia DiasKayleigh KewDavid M ClarkA E AdesStephen PillingSocial anxiety disorder is one of the most persistent and common anxiety disorders. Individually delivered psychological therapies are the most effective treatment options for adults with social anxiety disorder, but they are associated with high intervention costs. Therefore, the objective of this study was to assess the relative cost effectiveness of a variety of psychological and pharmacological interventions for adults with social anxiety disorder.A decision-analytic model was constructed to compare costs and quality adjusted life years (QALYs) of 28 interventions for social anxiety disorder from the perspective of the British National Health Service and personal social services. Efficacy data were derived from a systematic review and network meta-analysis. Other model input parameters were based on published literature and national sources, supplemented by expert opinion.Individual cognitive therapy was the most cost-effective intervention for adults with social anxiety disorder, followed by generic individual cognitive behavioural therapy (CBT), phenelzine and book-based self-help without support. Other drugs, group-based psychological interventions and other individually delivered psychological interventions were less cost-effective. Results were influenced by limited evidence suggesting superiority of psychological interventions over drugs in retaining long-term effects. The analysis did not take into account side effects of drugs.Various forms of individually delivered CBT appear to be the most cost-effective options for the treatment of adults with social anxiety disorder. Consideration of side effects of drugs would only strengthen this conclusion, as it would improve even further the cost effectiveness of individually delivered CBT relative to phenelzine, which was the next most cost-effective option, due to the serious side effects associated with phenelzine. Further research needs to determine more accurately the long-term comparative benefits and harms of psychological and pharmacological interventions for social anxiety disorder and establish their relative cost effectiveness with greater certainty.http://europepmc.org/articles/PMC4624770?pdf=render |
| spellingShingle | Ifigeneia Mavranezouli Evan Mayo-Wilson Sofia Dias Kayleigh Kew David M Clark A E Ades Stephen Pilling The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis. PLoS ONE |
| title | The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis. |
| title_full | The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis. |
| title_fullStr | The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis. |
| title_full_unstemmed | The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis. |
| title_short | The Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder: A Model-Based Economic Analysis. |
| title_sort | cost effectiveness of psychological and pharmacological interventions for social anxiety disorder a model based economic analysis |
| url | http://europepmc.org/articles/PMC4624770?pdf=render |
| work_keys_str_mv | AT ifigeneiamavranezouli thecosteffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT evanmayowilson thecosteffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT sofiadias thecosteffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT kayleighkew thecosteffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT davidmclark thecosteffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT aeades thecosteffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT stephenpilling thecosteffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT ifigeneiamavranezouli costeffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT evanmayowilson costeffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT sofiadias costeffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT kayleighkew costeffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT davidmclark costeffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT aeades costeffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis AT stephenpilling costeffectivenessofpsychologicalandpharmacologicalinterventionsforsocialanxietydisorderamodelbasedeconomicanalysis |