Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey
Abstract Background We aimed to compare differences in infant feeding patterns (breastfeeding and complementary food supplementation) between children with the autism spectrum disorder (ASD) and typically developing (TD) children through a multicentre study. The relationship between these patterns a...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-023-04667-2 |
| _version_ | 1797863876015947776 |
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| author | Xueli Xiang Ting Yang Jie Chen Li Chen Ying Dai Jie Zhang Ling Li Feiyong Jia Lijie Wu Yan Hao Xiaoyan Ke Mingji Yi Qi Hong Jinjin Chen Shuanfeng Fang Yichao Wang Qi Wang Chunhua Jin Tingyu Li |
| author_facet | Xueli Xiang Ting Yang Jie Chen Li Chen Ying Dai Jie Zhang Ling Li Feiyong Jia Lijie Wu Yan Hao Xiaoyan Ke Mingji Yi Qi Hong Jinjin Chen Shuanfeng Fang Yichao Wang Qi Wang Chunhua Jin Tingyu Li |
| author_sort | Xueli Xiang |
| collection | DOAJ |
| description | Abstract Background We aimed to compare differences in infant feeding patterns (breastfeeding and complementary food supplementation) between children with the autism spectrum disorder (ASD) and typically developing (TD) children through a multicentre study. The relationship between these patterns and later core symptoms and neurodevelopment in children with ASD was also investigated. Methods We analysed breastfeeding and complementary feeding patterns in 1389 children with ASD and 1190 TD children. The Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016) was used to assess neurodevelopmental levels. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), Childhood Autism Rating Scale (CARS), and ASD Warning Behavior Subscale of the CNBS-R2016 were used to assess ASD symptoms. Results Children with ASD had a shorter breastfeeding duration in infancy (8 (3–12) months vs. 10 (6–14) months, P < 0.001), later introduction of complementary foods (P < 0.001), and poorer acceptance of complementary foods (P < 0.001) than TD children. Total ABC and CARS scores were lower in the group of children with ASD who had been breastfed for 12 months or more than in the group who had been breastfed for less than 6 months. Children with ASD who were given complementary food after 6 months had lower general quotient (GQ), adaptive ability, fine motor and language scores than those who were given complementary food within 4–6 months. Children with ASD with poor acceptance of complementary foods had higher ABC and SRS scores and lower gross motor scores than those who had good acceptance. Conclusions Children with ASD have a shorter duration of breastfeeding, a later introduction of complementary foods, and poorer acceptance of complementary foods than TD children. These feeding patterns may be related to the symptoms and growth of children with ASD. The research suggests that continued breastfeeding for longer than 12 months may be beneficial in reducing ASD symptoms and that infants who have difficulty introducing complementary foods should be followed up for neurodevelopment. Trial registration The ethics committee of the Children’s Hospital of Chongqing Medical University approved the study. Approval Number: (2018) IRB (STUDY) NO. 121, and registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR2000031194, registered on 23/03/2020). |
| first_indexed | 2024-04-09T22:43:49Z |
| format | Article |
| id | doaj.art-71d3cf419d274f38985c37b0859d2354 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-09T22:43:49Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-71d3cf419d274f38985c37b0859d23542023-03-22T12:00:48ZengBMCBMC Psychiatry1471-244X2023-03-0123111210.1186/s12888-023-04667-2Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre surveyXueli Xiang0Ting Yang1Jie Chen2Li Chen3Ying Dai4Jie Zhang5Ling Li6Feiyong Jia7Lijie Wu8Yan Hao9Xiaoyan Ke10Mingji Yi11Qi Hong12Jinjin Chen13Shuanfeng Fang14Yichao Wang15Qi Wang16Chunhua Jin17Tingyu Li18Chongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Nutrition Research Center, National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Nutrition Research Center, National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Nutrition Research Center, National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Nutrition Research Center, National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Nutrition Research Center, National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical UniversityXi’an Children’s HospitalDepartment of Children Rehabilitation, Hainan Women and Children’s Medical CenterDepartment of Developmental and Behavioral Pediatric, The First Hospital of Jilin UniversityDepartment of Children’s and Adolescent Health, Public Health College of Harbin Medical UniversityDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChild Mental Health Research Center of Nanjing Brain HospitalDepartment of Child Health Care, The Affiliated Hospital of Qingdao UniversityMaternal and Child Health Hospital of BaoanDepartment of Child Healthcare, Shanghai Children’s Hospital, Shanghai Jiao Tong UniversityChildren’s Hospital Affiliated to Zhengzhou UniversityNHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care HospitalDeyang Maternity & Child Healthcare HospitalDepartment of Children Health Care, Capital Institute of PediatricsChongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Nutrition Research Center, National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical UniversityAbstract Background We aimed to compare differences in infant feeding patterns (breastfeeding and complementary food supplementation) between children with the autism spectrum disorder (ASD) and typically developing (TD) children through a multicentre study. The relationship between these patterns and later core symptoms and neurodevelopment in children with ASD was also investigated. Methods We analysed breastfeeding and complementary feeding patterns in 1389 children with ASD and 1190 TD children. The Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016) was used to assess neurodevelopmental levels. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), Childhood Autism Rating Scale (CARS), and ASD Warning Behavior Subscale of the CNBS-R2016 were used to assess ASD symptoms. Results Children with ASD had a shorter breastfeeding duration in infancy (8 (3–12) months vs. 10 (6–14) months, P < 0.001), later introduction of complementary foods (P < 0.001), and poorer acceptance of complementary foods (P < 0.001) than TD children. Total ABC and CARS scores were lower in the group of children with ASD who had been breastfed for 12 months or more than in the group who had been breastfed for less than 6 months. Children with ASD who were given complementary food after 6 months had lower general quotient (GQ), adaptive ability, fine motor and language scores than those who were given complementary food within 4–6 months. Children with ASD with poor acceptance of complementary foods had higher ABC and SRS scores and lower gross motor scores than those who had good acceptance. Conclusions Children with ASD have a shorter duration of breastfeeding, a later introduction of complementary foods, and poorer acceptance of complementary foods than TD children. These feeding patterns may be related to the symptoms and growth of children with ASD. The research suggests that continued breastfeeding for longer than 12 months may be beneficial in reducing ASD symptoms and that infants who have difficulty introducing complementary foods should be followed up for neurodevelopment. Trial registration The ethics committee of the Children’s Hospital of Chongqing Medical University approved the study. Approval Number: (2018) IRB (STUDY) NO. 121, and registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR2000031194, registered on 23/03/2020).https://doi.org/10.1186/s12888-023-04667-2Autism spectrum disorderFeeding patternsSymptomsNeurodevelopmentMulticenter survey |
| spellingShingle | Xueli Xiang Ting Yang Jie Chen Li Chen Ying Dai Jie Zhang Ling Li Feiyong Jia Lijie Wu Yan Hao Xiaoyan Ke Mingji Yi Qi Hong Jinjin Chen Shuanfeng Fang Yichao Wang Qi Wang Chunhua Jin Tingyu Li Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey BMC Psychiatry Autism spectrum disorder Feeding patterns Symptoms Neurodevelopment Multicenter survey |
| title | Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey |
| title_full | Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey |
| title_fullStr | Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey |
| title_full_unstemmed | Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey |
| title_short | Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey |
| title_sort | association of feeding patterns in infancy with later autism symptoms and neurodevelopment a national multicentre survey |
| topic | Autism spectrum disorder Feeding patterns Symptoms Neurodevelopment Multicenter survey |
| url | https://doi.org/10.1186/s12888-023-04667-2 |
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