HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies

HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies

Abstract TAR DNA‐binding protein 43 (TDP‐43) has been implicated in frontotemporal lobar degeneration with ubiquitin‐positive inclusions (FTLD‐TDP) and amyotrophic lateral sclerosis. Histone deacetylase 1 (HDAC1) is involved in DNA repair and neuroprotection in numerous neurodegenerative diseases. H...

Full description

Bibliographic Details
Main Authors:	Cheng‐Chun Wu, Lee‐Way Jin, I‐Fang Wang, Wei‐Yen Wei, Pei‐Chuan Ho, Yu‐Chih Liu, Kuen‐Jer Tsai
Format:	Article
Language:	English
Published:	Springer Nature 2020-06-01
Series:	EMBO Molecular Medicine
Subjects:	DNA damage FTLD HDAC1 TDP‐43
Online Access:	https://doi.org/10.15252/emmm.201910622

Similar Items

TDP-43 Proteinopathies: A New Player in Neurodegenerative Diseases with Defective Protein Folding
by: Suna Lahut, et al.
Published: (2012-03-01)

TDP-43 Proteinopathies: A New Player in Neurodegenerative Diseases with Defective Protein Folding
by: Suna Lahut, et al.
Published: (2012-03-01)

Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD
by: Tanzeen Yusuff, et al.
Published: (2023-03-01)

Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology
by: Yuan Tian, et al.
Published: (2021-12-01)

Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
by: Yuichi Riku, et al.
Published: (2021-04-01)

Aberrant TDP‐43 phosphorylation: a key wind gap from TDP‐43 to TDP‐43 proteinopathy
by: Zi‐Qi Huang, et al.
Published: (2021-06-01)

TDP-43 Epigenetic Facets and Their Neurodegenerative Implications
by: Juliette Gimenez, et al.
Published: (2023-09-01)

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons
by: Daiyu Honda, et al.
Published: (2014-01-01)

A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects
by: Simona Langellotti, et al.
Published: (2016-06-01)

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology
by: Yi-Chao Lee, et al.
Published: (2018-11-01)

TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration
by: Marina Buciuc, et al.
Published: (2022-01-01)

Mechanisms of TDP-43 Proteinopathy Onset and Propagation
by: Han-Jou Chen, et al.
Published: (2021-06-01)

Parkin beyond Parkinson’s Disease—A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies
by: Katarzyna Gaweda-Walerych, et al.
Published: (2021-12-01)

Restoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates
by: Hsiang-Yu Chang, et al.
Published: (2024-02-01)

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
by: Julie C Necarsulmer, et al.
Published: (2023-10-01)

The RNA-Recognition Motifs of TAR DNA-Binding Protein 43 May Play a Role in the Aberrant Self-Assembly of the Protein
by: Elsa Zacco, et al.
Published: (2018-10-01)

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
by: Britt A. Berning, et al.
Published: (2019-04-01)

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies
by: Yohei Iguchi, et al.
Published: (2012-03-01)

TDP-43 Proteinopathy Specific Biomarker Development
by: Isabell Cordts, et al.
Published: (2023-02-01)

Mitochondrion-Dependent Cell Death in TDP-43 Proteinopathies
by: Chantal B. Lucini, et al.
Published: (2021-04-01)

Incidence and morphology of secondary TDP-43 proteinopathies: Part 2
by: Albert Acewicz, et al.
Published: (2023-07-01)

Incidence and morphology of secondary TDP-43 proteinopathies: Part 1
by: Albert Acewicz, et al.
Published: (2022-11-01)

Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72
by: Mauricio Budini, et al.
Published: (2017-05-01)

Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes
by: Sandra O. Tomé, et al.
Published: (2020-04-01)

Pathological 25 kDa C-Terminal Fragments of TDP-43 Are Present in Lymphoblastoid Cell Lines and Extracellular Vesicles from Patients Affected by Frontotemporal Lobar Degeneration and Neuronal Ceroidolipofuscinosis Carrying a <i>GRN</i> Mutation
by: Sara Cimini, et al.
Published: (2022-11-01)

Heterogeneous Nuclear Ribonucleoprotein E2 (hnRNP E2) Is a Component of TDP-43 Aggregates Specifically in the A and C Pathological Subtypes of Frontotemporal Lobar Degeneration
by: Wejdan Kattuah, et al.
Published: (2019-06-01)

Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions
by: Guiomar Rodríguez-Periñán, et al.
Published: (2023-02-01)

TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
by: Yuichi Riku, et al.
Published: (2022-12-01)

Understanding In Vitro Pathways to Drug Discovery for TDP-43 Proteinopathies
by: Hei W. A. Cheng, et al.
Published: (2022-11-01)

Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases
by: Chiara F. Valori, et al.
Published: (2021-09-01)

Expanding the TDP-43 Proteinopathy Pathway From Neurons to Muscle: Physiological and Pathophysiological Functions
by: Lauren Versluys, et al.
Published: (2022-02-01)

Evaluation of cyanotoxin L-BMAA effect on α-synuclein and TDP43 proteinopathy
by: Paola Sini, et al.
Published: (2024-03-01)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
by: Rachel Atkinson, et al.
Published: (2021-02-01)

Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies
by: Non-Nuoc Tran, et al.
Published: (2022-09-01)

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
by: Laetitia Miguel, et al.
Published: (2011-02-01)

Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
by: Bilal Khalil, et al.
Published: (2022-12-01)

Transactive Response DNA-Binding Protein (TARDBP/TDP-43) Regulates Cell Permissivity to HIV-1 Infection by Acting on HDAC6
by: Romina Cabrera-Rodríguez, et al.
Published: (2022-05-01)

TDP-43 Pathology in Alzheimer’s Disease
by: Axel Meneses, et al.
Published: (2021-12-01)

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
by: Archana Prasad, et al.
Published: (2019-02-01)

Reviewing the Potential Links between Viral Infections and TDP-43 Proteinopathies
by: Zerina Rahic, et al.
Published: (2023-01-01)