A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation
This paper develops a multiplex RNA-seq method that reports tRNA abundance, modification, charging, and fragmentation. Results show stress-induced regulation in translational elongation and association of modification and tRNA fragment biogenesis.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30261-3 |
| _version_ | 1811307948418269184 |
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| author | Christopher P. Watkins Wen Zhang Adam C. Wylder Christopher D. Katanski Tao Pan |
| author_facet | Christopher P. Watkins Wen Zhang Adam C. Wylder Christopher D. Katanski Tao Pan |
| author_sort | Christopher P. Watkins |
| collection | DOAJ |
| description | This paper develops a multiplex RNA-seq method that reports tRNA abundance, modification, charging, and fragmentation. Results show stress-induced regulation in translational elongation and association of modification and tRNA fragment biogenesis. |
| first_indexed | 2024-04-13T09:13:27Z |
| format | Article |
| id | doaj.art-71d4401718c8473fb3cbaecdca743cef |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T09:13:27Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-71d4401718c8473fb3cbaecdca743cef2022-12-22T02:52:48ZengNature PortfolioNature Communications2041-17232022-05-0113111410.1038/s41467-022-30261-3A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulationChristopher P. Watkins0Wen Zhang1Adam C. Wylder2Christopher D. Katanski3Tao Pan4Department of Biochemistry and Molecular BiologyDepartment of Chemistry, University of ChicagoDepartment of Molecular Genetics and Cell Biology, University of ChicagoDepartment of Biochemistry and Molecular BiologyDepartment of Biochemistry and Molecular BiologyThis paper develops a multiplex RNA-seq method that reports tRNA abundance, modification, charging, and fragmentation. Results show stress-induced regulation in translational elongation and association of modification and tRNA fragment biogenesis.https://doi.org/10.1038/s41467-022-30261-3 |
| spellingShingle | Christopher P. Watkins Wen Zhang Adam C. Wylder Christopher D. Katanski Tao Pan A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation Nature Communications |
| title | A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation |
| title_full | A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation |
| title_fullStr | A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation |
| title_full_unstemmed | A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation |
| title_short | A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation |
| title_sort | multiplex platform for small rna sequencing elucidates multifaceted trna stress response and translational regulation |
| url | https://doi.org/10.1038/s41467-022-30261-3 |
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