Association between insulin resistance and c-reactive protein among Peruvian adults
<p>Abstract</p> <p>Objective</p> <p>Insulin resistance (IR), a reduced physiological response of peripheral tissues to the action of insulin, is one of the major causes of type 2 diabetes. We sought to evaluate the relationship between serum C-reactive protein (CRP), a...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
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BMC
2010-05-01
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Series: | Diabetology & Metabolic Syndrome |
Online Access: | http://www.dmsjournal.com/content/2/1/30 |
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author | Gelaye Bizu Revilla Luis Lopez Tania Suarez Luis Sanchez Sixto E Hevner Karin Fitzpatrick Annette L Williams Michelle A |
author_facet | Gelaye Bizu Revilla Luis Lopez Tania Suarez Luis Sanchez Sixto E Hevner Karin Fitzpatrick Annette L Williams Michelle A |
author_sort | Gelaye Bizu |
collection | DOAJ |
description | <p>Abstract</p> <p>Objective</p> <p>Insulin resistance (IR), a reduced physiological response of peripheral tissues to the action of insulin, is one of the major causes of type 2 diabetes. We sought to evaluate the relationship between serum C-reactive protein (CRP), a marker of systemic inflammation, and prevalence of IR among Peruvian adults.</p> <p>Methods</p> <p>This population based study of 1,525 individuals (569 men and 956 women; mean age 39 years old) was conducted among residents in Lima and Callao, Peru. Fasting plasma glucose, insulin, and CRP concentrations were measured using standard approaches. Insulin resistance was assessed using the homeostasis model (HOMA-IR). Categories of CRP were defined by the following tertiles: <0.81 mg/l, 0.81-2.53 mg/l, and >2.53 mg/l. Logistic regression procedures were employed to estimate odds ratios (OR) and 95% confidence intervals (CI).</p> <p>Results</p> <p>Elevated CRP were significantly associated with increased mean fasting insulin and mean HOMA-IR concentrations (p < 0.001). Women with CRP concentration >2.53 mg/l (upper tertile) had a 2.18-fold increased risk of IR (OR = 2.18 95% CI 1.51-3.16) as compared with those in the lowest tertile (<0.81 mg/l). Among men, those in the upper tertile had a 2.54-fold increased risk of IR (OR = 2.54 95% CI 1.54-4.20) as compared with those in the lowest tertile.</p> <p>Conclusion</p> <p>Our observations among Peruvians suggest that chronic systemic inflammation, as evidenced by elevated CRP, may be of etiologic importance in insulin resistance and diabetes.</p> |
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format | Article |
id | doaj.art-71d54b7fc9844f4283e6382195089ed0 |
institution | Directory Open Access Journal |
issn | 1758-5996 |
language | English |
last_indexed | 2024-04-12T16:11:53Z |
publishDate | 2010-05-01 |
publisher | BMC |
record_format | Article |
series | Diabetology & Metabolic Syndrome |
spelling | doaj.art-71d54b7fc9844f4283e6382195089ed02022-12-22T03:25:52ZengBMCDiabetology & Metabolic Syndrome1758-59962010-05-01213010.1186/1758-5996-2-30Association between insulin resistance and c-reactive protein among Peruvian adultsGelaye BizuRevilla LuisLopez TaniaSuarez LuisSanchez Sixto EHevner KarinFitzpatrick Annette LWilliams Michelle A<p>Abstract</p> <p>Objective</p> <p>Insulin resistance (IR), a reduced physiological response of peripheral tissues to the action of insulin, is one of the major causes of type 2 diabetes. We sought to evaluate the relationship between serum C-reactive protein (CRP), a marker of systemic inflammation, and prevalence of IR among Peruvian adults.</p> <p>Methods</p> <p>This population based study of 1,525 individuals (569 men and 956 women; mean age 39 years old) was conducted among residents in Lima and Callao, Peru. Fasting plasma glucose, insulin, and CRP concentrations were measured using standard approaches. Insulin resistance was assessed using the homeostasis model (HOMA-IR). Categories of CRP were defined by the following tertiles: <0.81 mg/l, 0.81-2.53 mg/l, and >2.53 mg/l. Logistic regression procedures were employed to estimate odds ratios (OR) and 95% confidence intervals (CI).</p> <p>Results</p> <p>Elevated CRP were significantly associated with increased mean fasting insulin and mean HOMA-IR concentrations (p < 0.001). Women with CRP concentration >2.53 mg/l (upper tertile) had a 2.18-fold increased risk of IR (OR = 2.18 95% CI 1.51-3.16) as compared with those in the lowest tertile (<0.81 mg/l). Among men, those in the upper tertile had a 2.54-fold increased risk of IR (OR = 2.54 95% CI 1.54-4.20) as compared with those in the lowest tertile.</p> <p>Conclusion</p> <p>Our observations among Peruvians suggest that chronic systemic inflammation, as evidenced by elevated CRP, may be of etiologic importance in insulin resistance and diabetes.</p>http://www.dmsjournal.com/content/2/1/30 |
spellingShingle | Gelaye Bizu Revilla Luis Lopez Tania Suarez Luis Sanchez Sixto E Hevner Karin Fitzpatrick Annette L Williams Michelle A Association between insulin resistance and c-reactive protein among Peruvian adults Diabetology & Metabolic Syndrome |
title | Association between insulin resistance and c-reactive protein among Peruvian adults |
title_full | Association between insulin resistance and c-reactive protein among Peruvian adults |
title_fullStr | Association between insulin resistance and c-reactive protein among Peruvian adults |
title_full_unstemmed | Association between insulin resistance and c-reactive protein among Peruvian adults |
title_short | Association between insulin resistance and c-reactive protein among Peruvian adults |
title_sort | association between insulin resistance and c reactive protein among peruvian adults |
url | http://www.dmsjournal.com/content/2/1/30 |
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