The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice
Background & Objectives: Retinoic acid is recognized as a regulator of the growth and cell differentiation and is necessary for normal reproductive in male and female. The present study was done to investigate the effect of retinoic acid on the uterine tissue and estradiol and progesterone hormo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2018-07-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1492-en.pdf |
| _version_ | 1797679628915048448 |
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| author | Arezo Mostaghimi Parvin Torabzadeh Khorasani Mina Ramezani |
| author_facet | Arezo Mostaghimi Parvin Torabzadeh Khorasani Mina Ramezani |
| author_sort | Arezo Mostaghimi |
| collection | DOAJ |
| description | Background & Objectives: Retinoic acid is recognized as a regulator of the growth and cell differentiation and is necessary for normal reproductive in male and female. The present study was done to investigate the effect of retinoic acid on the uterine tissue and estradiol and progesterone hormones in female adult BALB/c mice.
Material & Methods: In this study after determining the appropriate dose of retinoic acid, it was injected intraperitoneally (IP) for 30 days On 75 adult BALB/c mice with doses of 15 (Group I), 25 (Group II), and 35mg/kg.b.w (Group III), control group (non- injection) and sham (distilled water injection). ANOVA analysis and Duncan test were applied to compare the means with significance level (P˂0.05) and (P˂0.001).
Results: Uterine tissue studies indicated an increase in overall thickness of the uterus (endometrium, myometrium, perimeterum) (P<0.001), (P<0.05) increase number of closed glands, and decrease in open glands (P<0.001). The level of estradiol increased (P<0.05) and progesterone secretion decreased (P<0.05).
Conclusion: It can be concluded that retinoic acid has damaging effect on the uterus tissue and sexual hormones, and its use especially in female should be by awareness and under physician supervision. |
| first_indexed | 2024-03-11T23:17:34Z |
| format | Article |
| id | doaj.art-71d6b156695742fc988382deeb04ec68 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:34Z |
| publishDate | 2018-07-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-71d6b156695742fc988382deeb04ec682023-09-20T21:24:10ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232018-07-0182834840The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c miceArezo Mostaghimi0Parvin Torabzadeh Khorasani1Mina Ramezani2 Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Alborz, Iran Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Alborz, Iran Dept. of Biology, Islamic Azad University, Tehran, Iran Background & Objectives: Retinoic acid is recognized as a regulator of the growth and cell differentiation and is necessary for normal reproductive in male and female. The present study was done to investigate the effect of retinoic acid on the uterine tissue and estradiol and progesterone hormones in female adult BALB/c mice. Material & Methods: In this study after determining the appropriate dose of retinoic acid, it was injected intraperitoneally (IP) for 30 days On 75 adult BALB/c mice with doses of 15 (Group I), 25 (Group II), and 35mg/kg.b.w (Group III), control group (non- injection) and sham (distilled water injection). ANOVA analysis and Duncan test were applied to compare the means with significance level (P˂0.05) and (P˂0.001). Results: Uterine tissue studies indicated an increase in overall thickness of the uterus (endometrium, myometrium, perimeterum) (P<0.001), (P<0.05) increase number of closed glands, and decrease in open glands (P<0.001). The level of estradiol increased (P<0.05) and progesterone secretion decreased (P<0.05). Conclusion: It can be concluded that retinoic acid has damaging effect on the uterus tissue and sexual hormones, and its use especially in female should be by awareness and under physician supervision.http://jabs.fums.ac.ir/article-1-1492-en.pdfretinoic aciduterusestradiolprogesteronemice |
| spellingShingle | Arezo Mostaghimi Parvin Torabzadeh Khorasani Mina Ramezani The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice Journal of Advanced Biomedical Sciences retinoic acid uterus estradiol progesterone mice |
| title | The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice |
| title_full | The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice |
| title_fullStr | The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice |
| title_full_unstemmed | The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice |
| title_short | The effect of retinoic acid on uterine tissue and estradiol, progesterone hormones in female adult BALB/c mice |
| title_sort | effect of retinoic acid on uterine tissue and estradiol progesterone hormones in female adult balb c mice |
| topic | retinoic acid uterus estradiol progesterone mice |
| url | http://jabs.fums.ac.ir/article-1-1492-en.pdf |
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