The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye
Dry eye disease is a common condition in patients of all ages, causing discomfort and potential visual problems. Current treatments, including artificial tears and anti-inflammatory drugs, have certain limitations, encouraging research into alternative therapies. We investigated the therapeutic pote...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/24/17493 |
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| author | Hyeyoon Goo Yea-Jin Lee Sangkeun Lee Namgue Hong |
| author_facet | Hyeyoon Goo Yea-Jin Lee Sangkeun Lee Namgue Hong |
| author_sort | Hyeyoon Goo |
| collection | DOAJ |
| description | Dry eye disease is a common condition in patients of all ages, causing discomfort and potential visual problems. Current treatments, including artificial tears and anti-inflammatory drugs, have certain limitations, encouraging research into alternative therapies. We investigated the therapeutic potential of multi-wavelength light-emitting diode (LED) irradiation of mice with dry eye. First, we showed that multi-wavelength LED irradiation was non-toxic to human corneal epithelial cells and improved cell viability. We then used a scopolamine-induced mouse model of dry eye to assess the effects of multi-wavelength LED irradiation on various clinical parameters. This treatment increased the tear volume and reduced corneal irregularity, thus improving dry eye. Histological analysis revealed that multi-wavelength LED irradiation protected against corneal epithelial damage and the associated reduction in epithelial thickness and would thus improve the corneal health of dry eye patients. Multi-wavelength LED irradiation significantly reduced the corneal levels of pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; the treatment was thus anti-inflammatory. Our results suggest that multi-wavelength LED irradiation may serve as a safe and effective treatment for dry eye, alleviating symptoms, reducing inflammation, and promoting corneal health. |
| first_indexed | 2024-03-08T20:40:50Z |
| format | Article |
| id | doaj.art-71d6d94dab804222b5931145140de534 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T20:40:50Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-71d6d94dab804222b5931145140de5342023-12-22T14:14:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124241749310.3390/ijms242417493The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry EyeHyeyoon Goo0Yea-Jin Lee1Sangkeun Lee2Namgue Hong3Department of Medical Laser, Graduate School of Medicine, Dankook University, Cheonan 31116, Republic of KoreaBeckman Laser Institute Korea, Dankook University, Cheonan 31116, Republic of KoreaMEDI-IOT Co., Ltd., Seoul 02708, Republic of KoreaBeckman Laser Institute Korea, Dankook University, Cheonan 31116, Republic of KoreaDry eye disease is a common condition in patients of all ages, causing discomfort and potential visual problems. Current treatments, including artificial tears and anti-inflammatory drugs, have certain limitations, encouraging research into alternative therapies. We investigated the therapeutic potential of multi-wavelength light-emitting diode (LED) irradiation of mice with dry eye. First, we showed that multi-wavelength LED irradiation was non-toxic to human corneal epithelial cells and improved cell viability. We then used a scopolamine-induced mouse model of dry eye to assess the effects of multi-wavelength LED irradiation on various clinical parameters. This treatment increased the tear volume and reduced corneal irregularity, thus improving dry eye. Histological analysis revealed that multi-wavelength LED irradiation protected against corneal epithelial damage and the associated reduction in epithelial thickness and would thus improve the corneal health of dry eye patients. Multi-wavelength LED irradiation significantly reduced the corneal levels of pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; the treatment was thus anti-inflammatory. Our results suggest that multi-wavelength LED irradiation may serve as a safe and effective treatment for dry eye, alleviating symptoms, reducing inflammation, and promoting corneal health.https://www.mdpi.com/1422-0067/24/24/17493dry eyemulti-wavelength LEDphotobiomodulationcorneapro-inflammatory cytokinescopolamine |
| spellingShingle | Hyeyoon Goo Yea-Jin Lee Sangkeun Lee Namgue Hong The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye International Journal of Molecular Sciences dry eye multi-wavelength LED photobiomodulation cornea pro-inflammatory cytokine scopolamine |
| title | The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye |
| title_full | The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye |
| title_fullStr | The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye |
| title_full_unstemmed | The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye |
| title_short | The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye |
| title_sort | anti inflammatory effect of multi wavelength light emitting diode irradiation attenuates dry eye symptoms in a scopolamine induced mouse model of dry eye |
| topic | dry eye multi-wavelength LED photobiomodulation cornea pro-inflammatory cytokine scopolamine |
| url | https://www.mdpi.com/1422-0067/24/24/17493 |
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