Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients.
BACKGROUND: The CYP2E1 and GSTM1 genes encode metabolic enzymes that have key functions in drug modification and elimination. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the possible effects of CYP2E1 and GSTM1 polymorphisms in 71 leprosy patients and in 110 individuals from the general populati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3471857?pdf=render |
| _version_ | 1818137413436833792 |
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| author | Pablo Pinto Claudio Guedes Salgado Ney Santos Dayse O Alencar Sidney Santos Mara H Hutz Ândrea Ribeiro-dos-Santos |
| author_facet | Pablo Pinto Claudio Guedes Salgado Ney Santos Dayse O Alencar Sidney Santos Mara H Hutz Ândrea Ribeiro-dos-Santos |
| author_sort | Pablo Pinto |
| collection | DOAJ |
| description | BACKGROUND: The CYP2E1 and GSTM1 genes encode metabolic enzymes that have key functions in drug modification and elimination. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the possible effects of CYP2E1 and GSTM1 polymorphisms in 71 leprosy patients and in 110 individuals from the general population. The GSTM1*0 null allele and INDEL CYP2E1*1D mutant genotypes were analyzed by conventional PCR, while CYP2E1 SNPs (1053C>T, 1293G>C and 7632T>A) were determined by RT-PCR. In leprosy patients, the GSTM1*0 and CYP2E1*5 alleles and the combined alleles GSTM1*0/CYP2E1*6 and GSTM1*0/CYP2E1*5 were significantly related to a baciloscopic index (BI) (BI<3), while the CYP2E1*6 allele was related to a better clinical evolution in the leprosy spectrum. CONCLUSIONS/SIGNIFICANCE: Therefore, GSTM1*0, CYP2E1*5 and CYP2E1*6 may be possible protection factors for leprosy patients. |
| first_indexed | 2024-12-11T09:55:54Z |
| format | Article |
| id | doaj.art-71d798009418421a81a0b43fa3bca46f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T09:55:54Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-71d798009418421a81a0b43fa3bca46f2022-12-22T01:12:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4749810.1371/journal.pone.0047498Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients.Pablo PintoClaudio Guedes SalgadoNey SantosDayse O AlencarSidney SantosMara H HutzÂndrea Ribeiro-dos-SantosBACKGROUND: The CYP2E1 and GSTM1 genes encode metabolic enzymes that have key functions in drug modification and elimination. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the possible effects of CYP2E1 and GSTM1 polymorphisms in 71 leprosy patients and in 110 individuals from the general population. The GSTM1*0 null allele and INDEL CYP2E1*1D mutant genotypes were analyzed by conventional PCR, while CYP2E1 SNPs (1053C>T, 1293G>C and 7632T>A) were determined by RT-PCR. In leprosy patients, the GSTM1*0 and CYP2E1*5 alleles and the combined alleles GSTM1*0/CYP2E1*6 and GSTM1*0/CYP2E1*5 were significantly related to a baciloscopic index (BI) (BI<3), while the CYP2E1*6 allele was related to a better clinical evolution in the leprosy spectrum. CONCLUSIONS/SIGNIFICANCE: Therefore, GSTM1*0, CYP2E1*5 and CYP2E1*6 may be possible protection factors for leprosy patients.http://europepmc.org/articles/PMC3471857?pdf=render |
| spellingShingle | Pablo Pinto Claudio Guedes Salgado Ney Santos Dayse O Alencar Sidney Santos Mara H Hutz Ândrea Ribeiro-dos-Santos Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients. PLoS ONE |
| title | Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients. |
| title_full | Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients. |
| title_fullStr | Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients. |
| title_full_unstemmed | Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients. |
| title_short | Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients. |
| title_sort | polymorphisms in the cyp2e1 and gstm1 genes as possible protection factors for leprosy patients |
| url | http://europepmc.org/articles/PMC3471857?pdf=render |
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