Gefitinib loaded nanostructured lipid carriers: characterization, evaluation and anti-human colon cancer activity in vitro

Gefitinib loaded nanostructured lipid carriers: characterization, evaluation and anti-human colon cancer activity in vitro

NLC containing Gefitinib (NANOGEF) was prepared using stearic acid, sesame oil and surfactants (sodium lauryl sulfate and tween 80). NANOGEFs were evaluated for particle size, polydispersity index (PdI), zeta potential, entrapment efficiency (EE), stability, release studies and cytotoxicity studies...

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Bibliographic Details
Main Authors: Hafiz A. Makeen, Syam Mohan, Mohamed Ahmed Al-Kasim, Ibraheem M. Attafi, Rayan A. Ahmed, Nabeel Kashan Syed, Muhammad Hadi Sultan, Mohammed Al-Bratty, Hassan A. Alhazmi, Mohammed M. Safhi, Raisuddin Ali, M. Intakhab Alam
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
gefitinib
tween 80
nanostructured lipid carriers
sodium lauryl sulfate
mtt assay
colorectal cancer
Online Access:http://dx.doi.org/10.1080/10717544.2020.1754526

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