Research Progress for Targeting Deubiquitinases in Gastric Cancers
Gastric cancers (GCs) are malignant tumors with a high incidence that threaten global public health. Despite advances in GC diagnosis and treatment, the prognosis remains poor. Therefore, the mechanisms underlying GC progression need to be identified to develop prognostic biomarkers and therapeutic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/23/5831 |
| _version_ | 1797463550983143424 |
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| author | Tao An Yanting Lu Zhaoqi Gong Yongtao Wang Chen Su Guimei Tang Jingjing Hou |
| author_facet | Tao An Yanting Lu Zhaoqi Gong Yongtao Wang Chen Su Guimei Tang Jingjing Hou |
| author_sort | Tao An |
| collection | DOAJ |
| description | Gastric cancers (GCs) are malignant tumors with a high incidence that threaten global public health. Despite advances in GC diagnosis and treatment, the prognosis remains poor. Therefore, the mechanisms underlying GC progression need to be identified to develop prognostic biomarkers and therapeutic targets. Ubiquitination, a post-translational modification that regulates the stability, activity, localization, and interactions of target proteins, can be reversed by deubiquitinases (DUBs), which can remove ubiquitin monomers or polymers from modified proteins. The dysfunction of DUBs has been closely linked to tumorigenesis in various cancer types, and targeting certain DUBs may provide a potential option for cancer therapy. Multiple DUBs have been demonstrated to function as oncogenes or tumor suppressors in GC. In this review, we summarize the DUBs involved in GC and their associated upstream regulation and downstream mechanisms and present the benefits of targeting DUBs for GC treatment, which could provide new insights for GC diagnosis and therapy. |
| first_indexed | 2024-03-09T17:52:19Z |
| format | Article |
| id | doaj.art-71da0ed53e89454383f1d41f973eeb39 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:52:19Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-71da0ed53e89454383f1d41f973eeb392023-11-24T10:39:23ZengMDPI AGCancers2072-66942022-11-011423583110.3390/cancers14235831Research Progress for Targeting Deubiquitinases in Gastric CancersTao An0Yanting Lu1Zhaoqi Gong2Yongtao Wang3Chen Su4Guimei Tang5Jingjing Hou6School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250353, ChinaSchool of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaSchool of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaDepartment of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaSchool of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, ChinaDepartment of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaGastric cancers (GCs) are malignant tumors with a high incidence that threaten global public health. Despite advances in GC diagnosis and treatment, the prognosis remains poor. Therefore, the mechanisms underlying GC progression need to be identified to develop prognostic biomarkers and therapeutic targets. Ubiquitination, a post-translational modification that regulates the stability, activity, localization, and interactions of target proteins, can be reversed by deubiquitinases (DUBs), which can remove ubiquitin monomers or polymers from modified proteins. The dysfunction of DUBs has been closely linked to tumorigenesis in various cancer types, and targeting certain DUBs may provide a potential option for cancer therapy. Multiple DUBs have been demonstrated to function as oncogenes or tumor suppressors in GC. In this review, we summarize the DUBs involved in GC and their associated upstream regulation and downstream mechanisms and present the benefits of targeting DUBs for GC treatment, which could provide new insights for GC diagnosis and therapy.https://www.mdpi.com/2072-6694/14/23/5831gastric cancerdeubiquitinasesbiomarkerstumorigenesispathogenesisdiagnosis |
| spellingShingle | Tao An Yanting Lu Zhaoqi Gong Yongtao Wang Chen Su Guimei Tang Jingjing Hou Research Progress for Targeting Deubiquitinases in Gastric Cancers Cancers gastric cancer deubiquitinases biomarkers tumorigenesis pathogenesis diagnosis |
| title | Research Progress for Targeting Deubiquitinases in Gastric Cancers |
| title_full | Research Progress for Targeting Deubiquitinases in Gastric Cancers |
| title_fullStr | Research Progress for Targeting Deubiquitinases in Gastric Cancers |
| title_full_unstemmed | Research Progress for Targeting Deubiquitinases in Gastric Cancers |
| title_short | Research Progress for Targeting Deubiquitinases in Gastric Cancers |
| title_sort | research progress for targeting deubiquitinases in gastric cancers |
| topic | gastric cancer deubiquitinases biomarkers tumorigenesis pathogenesis diagnosis |
| url | https://www.mdpi.com/2072-6694/14/23/5831 |
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