TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors

TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors

Binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to the plasma membrane TRAIL-R1/-R2 selectively kills tumor cells. This discovery led to evaluation of TRAIL-R1/-R2 as targets for anti-cancer therapy, yet the corresponding clinical trials were disappointing. Meanwhile, it e...

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Bibliographic Details
Main Authors: Ufuk Mert, Alshaimaa Adawy, Elisabeth Scharff, Pierre Teichmann, Anna Willms, Verena Haselmann, Cynthia Colmorgen, Johannes Lemke, Silvia von Karstedt, Jürgen Fritsch, Anna Trauzold
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
TRAIL
nuclear TRAIL-R1
nuclear TRAIL-R2
trafficking
CRM-1
Online Access:https://www.mdpi.com/2072-6694/11/8/1167

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