Metabolism of Amino Acids in Cancer
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.603837/full |
| _version_ | 1818591876265017344 |
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| author | Zhen Wei Xiaoyi Liu Chunming Cheng Wei Yu Ping Yi |
| author_facet | Zhen Wei Xiaoyi Liu Chunming Cheng Wei Yu Ping Yi |
| author_sort | Zhen Wei |
| collection | DOAJ |
| description | Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications. |
| first_indexed | 2024-12-16T10:19:24Z |
| format | Article |
| id | doaj.art-71dbfdf38801455d9043b7bad1b1ad5e |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T10:19:24Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-71dbfdf38801455d9043b7bad1b1ad5e2022-12-21T22:35:21ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01810.3389/fcell.2020.603837603837Metabolism of Amino Acids in CancerZhen Wei0Xiaoyi Liu1Chunming Cheng2Wei Yu3Ping Yi4Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Brain Science and Advanced Technology Institute, Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiation Oncology, James Comprehensive Cancer Center and College of Medicine at The Ohio State University, Columbus, OH, United StatesState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaMetabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications.https://www.frontiersin.org/articles/10.3389/fcell.2020.603837/fullamino acids (AAs)metabolismcancermTORC (mammalian target of rapamycin kinase complex)epigenetictumor immunity |
| spellingShingle | Zhen Wei Xiaoyi Liu Chunming Cheng Wei Yu Ping Yi Metabolism of Amino Acids in Cancer Frontiers in Cell and Developmental Biology amino acids (AAs) metabolism cancer mTORC (mammalian target of rapamycin kinase complex) epigenetic tumor immunity |
| title | Metabolism of Amino Acids in Cancer |
| title_full | Metabolism of Amino Acids in Cancer |
| title_fullStr | Metabolism of Amino Acids in Cancer |
| title_full_unstemmed | Metabolism of Amino Acids in Cancer |
| title_short | Metabolism of Amino Acids in Cancer |
| title_sort | metabolism of amino acids in cancer |
| topic | amino acids (AAs) metabolism cancer mTORC (mammalian target of rapamycin kinase complex) epigenetic tumor immunity |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.603837/full |
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