Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral Hemorrhage
Objective: Remote diffusion-weighted imaging (DWI) lesions (R-DWIL) found in intracerebral hemorrhage (ICH) patients are considered as an additional marker of cerebral small vessel disease (cSVD). This study aimed to investigate the association of renal dysfunction and R-DWIL, as well as the total b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00171/full |
| _version_ | 1811262486286958592 |
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| author | Xu-hua Xu Xu-hua Xu Xiang-hua Ye Jin-song Cai Ting Gao Guo-hua Zhao Guo-hua Zhao Wen-ji Zhang Lu-sha Tong Feng Gao Feng Gao |
| author_facet | Xu-hua Xu Xu-hua Xu Xiang-hua Ye Jin-song Cai Ting Gao Guo-hua Zhao Guo-hua Zhao Wen-ji Zhang Lu-sha Tong Feng Gao Feng Gao |
| author_sort | Xu-hua Xu |
| collection | DOAJ |
| description | Objective: Remote diffusion-weighted imaging (DWI) lesions (R-DWIL) found in intracerebral hemorrhage (ICH) patients are considered as an additional marker of cerebral small vessel disease (cSVD). This study aimed to investigate the association of renal dysfunction and R-DWIL, as well as the total burden of cSVD on magnetic resonance imaging among patients with primary ICH.Methods: One hundred and twenty-six consecutive patients were prospectively enrolled. R-DWIL on DWI, as well as other imaging markers of cSVD, including lacunes, white matter lesions, cerebral microbleeds, and enlarged perivascular spaces were rated using validated scales. Renal dysfunction was evaluated either by reduced estimated glomerular filtration rate (eGFR) or the presence of proteinuria or increased cystatin C.Results: After adjustments for potential confounders by logistic regression, impaired eGFR [odds ratio (OR) 6.00, 95% confidence interval (CI) 1.73–20.78], proteinuria (OR 3.07, 95% CI 1.25–7.54) and increased cystatin C (OR 2.73, 95% CI 1.11–6.72) were correlated with presence of R-DWIL. A similar association was also found between cystatin C levels (OR 3.16, 95% CI 1.39–7.19), proteinuria (OR 2.79, 95% CI 1.34–5.83) and the comprehensive cSVD burden.Conclusions: Renal dysfunction are associated with the presence of R-DWIL, and total burden of cSVD in patients with primary ICH. |
| first_indexed | 2024-04-12T19:27:30Z |
| format | Article |
| id | doaj.art-71de0aae142a47c1940243cfc5aff3aa |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T19:27:30Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-71de0aae142a47c1940243cfc5aff3aa2022-12-22T03:19:27ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-06-011010.3389/fnagi.2018.00171346442Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral HemorrhageXu-hua Xu0Xu-hua Xu1Xiang-hua Ye2Jin-song Cai3Ting Gao4Guo-hua Zhao5Guo-hua Zhao6Wen-ji Zhang7Lu-sha Tong8Feng Gao9Feng Gao10Department of Neurology, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, ChinaSchool of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, ChinaDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Radiology, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, ChinaDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaSchool of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaObjective: Remote diffusion-weighted imaging (DWI) lesions (R-DWIL) found in intracerebral hemorrhage (ICH) patients are considered as an additional marker of cerebral small vessel disease (cSVD). This study aimed to investigate the association of renal dysfunction and R-DWIL, as well as the total burden of cSVD on magnetic resonance imaging among patients with primary ICH.Methods: One hundred and twenty-six consecutive patients were prospectively enrolled. R-DWIL on DWI, as well as other imaging markers of cSVD, including lacunes, white matter lesions, cerebral microbleeds, and enlarged perivascular spaces were rated using validated scales. Renal dysfunction was evaluated either by reduced estimated glomerular filtration rate (eGFR) or the presence of proteinuria or increased cystatin C.Results: After adjustments for potential confounders by logistic regression, impaired eGFR [odds ratio (OR) 6.00, 95% confidence interval (CI) 1.73–20.78], proteinuria (OR 3.07, 95% CI 1.25–7.54) and increased cystatin C (OR 2.73, 95% CI 1.11–6.72) were correlated with presence of R-DWIL. A similar association was also found between cystatin C levels (OR 3.16, 95% CI 1.39–7.19), proteinuria (OR 2.79, 95% CI 1.34–5.83) and the comprehensive cSVD burden.Conclusions: Renal dysfunction are associated with the presence of R-DWIL, and total burden of cSVD in patients with primary ICH.https://www.frontiersin.org/article/10.3389/fnagi.2018.00171/fullcerebral small vessel diseaseremote DWI lesionsglomerular filtration ratecystatin Cproteinuriarenal dysfunction |
| spellingShingle | Xu-hua Xu Xu-hua Xu Xiang-hua Ye Jin-song Cai Ting Gao Guo-hua Zhao Guo-hua Zhao Wen-ji Zhang Lu-sha Tong Feng Gao Feng Gao Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral Hemorrhage Frontiers in Aging Neuroscience cerebral small vessel disease remote DWI lesions glomerular filtration rate cystatin C proteinuria renal dysfunction |
| title | Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral Hemorrhage |
| title_full | Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral Hemorrhage |
| title_fullStr | Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral Hemorrhage |
| title_full_unstemmed | Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral Hemorrhage |
| title_short | Association of Renal Dysfunction With Remote Diffusion-Weighted Imaging Lesions and Total Burden of Cerebral Small Vessel Disease in Patients With Primary Intracerebral Hemorrhage |
| title_sort | association of renal dysfunction with remote diffusion weighted imaging lesions and total burden of cerebral small vessel disease in patients with primary intracerebral hemorrhage |
| topic | cerebral small vessel disease remote DWI lesions glomerular filtration rate cystatin C proteinuria renal dysfunction |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00171/full |
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