<i>Platanus hybrida</i>’s Phenolic Profile, Antioxidant Power, and Antibacterial Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA)
Methicillin-resistant <i>S. aureus</i> (MRSA) are a threat to public health as they frequently reveal a multidrug-resistant pattern. Researchers all over the world are on an urgent hunt for new treatments to help fight infections before antibiotics become obsolete, and some natural alter...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Horticulturae |
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| Online Access: | https://www.mdpi.com/2311-7524/8/3/243 |
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| author | Jessica Ribeiro Vanessa Silva Alfredo Aires Rosa Carvalho Lillian Barros Isabel Gaivão Gilberto Igrejas Patrícia Poeta |
| author_facet | Jessica Ribeiro Vanessa Silva Alfredo Aires Rosa Carvalho Lillian Barros Isabel Gaivão Gilberto Igrejas Patrícia Poeta |
| author_sort | Jessica Ribeiro |
| collection | DOAJ |
| description | Methicillin-resistant <i>S. aureus</i> (MRSA) are a threat to public health as they frequently reveal a multidrug-resistant pattern. Researchers all over the world are on an urgent hunt for new treatments to help fight infections before antibiotics become obsolete, and some natural alternatives, such as polyphenols, have already exhibited therapeutic properties. Therefore, this study aimed to determine the phenolic profile, antioxidant capacity, and antimicrobial activity against MRSA of the leaf, fruit, and stem bark extracts of <i>Platanus hybrida</i>. The polyphenols were extracted with a water/ethanol (20:80) mixture and the methodology included HPLC-DAD, DPPH, FRAP, and CuPRAC. To address this issue from a One Health perspective, the Kirby–Bauer disc diffusion method was performed against nine MRSA strains from three different sources (livestock, wild animals, and humans). Fourteen phenolics were identified and the leaf extract showed the highest phenolic content, followed by the fruit extract. The leaf extract also showed the highest antioxidant capacity while the fruit extract had the lowest antioxidant capacity. Both leaf and fruit extracts inhibited the growth of strains from all sources, while the stem bark extract did not inhibit the growth of human strains. This work highlights the complex chemical composition and the antioxidative and antimicrobial potential of extracts derived from <i>P. hydrida</i>. |
| first_indexed | 2024-03-09T19:45:25Z |
| format | Article |
| id | doaj.art-71de4a1d841d4d409929e5e093d6e33f |
| institution | Directory Open Access Journal |
| issn | 2311-7524 |
| language | English |
| last_indexed | 2024-03-09T19:45:25Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Horticulturae |
| spelling | doaj.art-71de4a1d841d4d409929e5e093d6e33f2023-11-24T01:25:54ZengMDPI AGHorticulturae2311-75242022-03-018324310.3390/horticulturae8030243<i>Platanus hybrida</i>’s Phenolic Profile, Antioxidant Power, and Antibacterial Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA)Jessica Ribeiro0Vanessa Silva1Alfredo Aires2Rosa Carvalho3Lillian Barros4Isabel Gaivão5Gilberto Igrejas6Patrícia Poeta7Microbiology and Antibiotic Resistance Team (MicroART), Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalMicrobiology and Antibiotic Resistance Team (MicroART), Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalCentre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalDepartment of Agronomy, School of Agrarian and Veterinary Sciences, University of Trás-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, PortugalCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança (IPB), 5300-253 Bragança, PortugalDepartment of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalAssociated Laboratory for Green Chemistry (LAQV-REQUIMTE), University NOVA of Lisbon, 2829-516 Caparica, PortugalMicrobiology and Antibiotic Resistance Team (MicroART), Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, PortugalMethicillin-resistant <i>S. aureus</i> (MRSA) are a threat to public health as they frequently reveal a multidrug-resistant pattern. Researchers all over the world are on an urgent hunt for new treatments to help fight infections before antibiotics become obsolete, and some natural alternatives, such as polyphenols, have already exhibited therapeutic properties. Therefore, this study aimed to determine the phenolic profile, antioxidant capacity, and antimicrobial activity against MRSA of the leaf, fruit, and stem bark extracts of <i>Platanus hybrida</i>. The polyphenols were extracted with a water/ethanol (20:80) mixture and the methodology included HPLC-DAD, DPPH, FRAP, and CuPRAC. To address this issue from a One Health perspective, the Kirby–Bauer disc diffusion method was performed against nine MRSA strains from three different sources (livestock, wild animals, and humans). Fourteen phenolics were identified and the leaf extract showed the highest phenolic content, followed by the fruit extract. The leaf extract also showed the highest antioxidant capacity while the fruit extract had the lowest antioxidant capacity. Both leaf and fruit extracts inhibited the growth of strains from all sources, while the stem bark extract did not inhibit the growth of human strains. This work highlights the complex chemical composition and the antioxidative and antimicrobial potential of extracts derived from <i>P. hydrida</i>.https://www.mdpi.com/2311-7524/8/3/243antimicrobial activityantioxidant activitydrug-resistant bacteriaMRSAOne Healthphenolic compounds |
| spellingShingle | Jessica Ribeiro Vanessa Silva Alfredo Aires Rosa Carvalho Lillian Barros Isabel Gaivão Gilberto Igrejas Patrícia Poeta <i>Platanus hybrida</i>’s Phenolic Profile, Antioxidant Power, and Antibacterial Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Horticulturae antimicrobial activity antioxidant activity drug-resistant bacteria MRSA One Health phenolic compounds |
| title | <i>Platanus hybrida</i>’s Phenolic Profile, Antioxidant Power, and Antibacterial Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) |
| title_full | <i>Platanus hybrida</i>’s Phenolic Profile, Antioxidant Power, and Antibacterial Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) |
| title_fullStr | <i>Platanus hybrida</i>’s Phenolic Profile, Antioxidant Power, and Antibacterial Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) |
| title_full_unstemmed | <i>Platanus hybrida</i>’s Phenolic Profile, Antioxidant Power, and Antibacterial Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) |
| title_short | <i>Platanus hybrida</i>’s Phenolic Profile, Antioxidant Power, and Antibacterial Activity against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) |
| title_sort | i platanus hybrida i s phenolic profile antioxidant power and antibacterial activity against methicillin resistant i staphylococcus aureus i mrsa |
| topic | antimicrobial activity antioxidant activity drug-resistant bacteria MRSA One Health phenolic compounds |
| url | https://www.mdpi.com/2311-7524/8/3/243 |
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