Association between <i>PYTPN22</i> rs2476601, <i>VEGF</i> rs833070, <i>TNFAIP3</i> rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study
<i>Background and Objectives</i>: About 40% of early undifferentiated arthritis (UA) progresses to rheumatoid (RA) or other chronic arthritis. Novel diagnostic tools predicting the risk for this progression are needed to identify the patients who would benefit from early aggressive treat...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/10/1824 |
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| author | Regina Sakalyte Sigita Stropuviene Gabija Jasionyte Loreta Bagdonaite Algirdas Venalis |
| author_facet | Regina Sakalyte Sigita Stropuviene Gabija Jasionyte Loreta Bagdonaite Algirdas Venalis |
| author_sort | Regina Sakalyte |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: About 40% of early undifferentiated arthritis (UA) progresses to rheumatoid (RA) or other chronic arthritis. Novel diagnostic tools predicting the risk for this progression are needed to identify the patients who would benefit from early aggressive treatment. Evidence on the role of single-nucleotide polymorphisms (SNPs) in the development of RA has emerged. The aim of our study was to investigate the association between rs2476601, rs833070, and rs6920220 SNPs and UA progression to RA. <i>Materials and Methods</i>: Ninety-two UA patients were observed for 12 months. At study entry, demographic and clinical characteristics were recorded, musculoskeletal ultrasonography was performed, and blood samples were drawn to investigate levels of inflammatory markers, rheumatoid factor (RF), anti-citrullinated protein antibodies (anti-CCP)detect SNPs. After 12 months, UA outcomes were assessed, and patients were divided into two (RA and non-RA) groups. The association between the risk of progression to chronic inflammatory arthritis and analyzed SNPs was measured by computing odds ratios (OR). <i>Results</i>: After a 12-month follow-up, 27 (29.3%) patients developed RA, and 65 (70.7%) patients were assigned to the non-RA group. The arthritis of 21 patients (22.8%) from the non-RA group resolved completely, while the other 44 (47.2%) patients were diagnosed with another rheumatic inflammatory disease. The patients who developed RA had a significantly greater number of tender and swollen joints (<i>p</i> = 0.010 and <i>p</i> = 0.021 respectively) and were more frequently RF or anti-CCP (<i>p</i> < 0.001), and both RF and anti-CCP positive (<i>p</i> < 0.001) at the baseline as compared with the patients in the non-RA group. No significant association between rs2476601 (OR = 0.99, <i>p</i> = 0.98), rs833070 (OR = 1.0, <i>p</i> = 0.97), and rs6920220 (OR = 0.48, <i>p</i> = 0.13) polymorphisms and the risk of developing RA were found. <i>Conclusions</i>: No association between analyzed SNPs and a greater risk to progress from UA to RA was confirmed, although patients with rs6920220 <i>AA</i> + <i>AG</i> genotypes had fewer tender joints at the disease onset. |
| first_indexed | 2024-03-10T21:03:34Z |
| format | Article |
| id | doaj.art-71de57d27147458db85bb8ea503e0b61 |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T21:03:34Z |
| publishDate | 2023-10-01 |
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| spelling | doaj.art-71de57d27147458db85bb8ea503e0b612023-11-19T17:17:48ZengMDPI AGMedicina1010-660X1648-91442023-10-015910182410.3390/medicina59101824Association between <i>PYTPN22</i> rs2476601, <i>VEGF</i> rs833070, <i>TNFAIP3</i> rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot StudyRegina Sakalyte0Sigita Stropuviene1Gabija Jasionyte2Loreta Bagdonaite3Algirdas Venalis4The Clinic of Rheumatology, Traumatology Orthopaedics and Reconstructive Surgery, Institute of Clinical Medicine of the Faculty of Vilnius University, M. K. Čiurlionio Str. 21, 03101 Vilnius, LithuaniaThe Clinic of Rheumatology, Traumatology Orthopaedics and Reconstructive Surgery, Institute of Clinical Medicine of the Faculty of Vilnius University, M. K. Čiurlionio Str. 21, 03101 Vilnius, LithuaniaThe Clinic of Rheumatology, Traumatology Orthopaedics and Reconstructive Surgery, Institute of Clinical Medicine of the Faculty of Vilnius University, M. K. Čiurlionio Str. 21, 03101 Vilnius, LithuaniaDepartment of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Faculty of Medicine, Vilnius University, M. K. Čiurlionio Str. 21, 03101 Vilnius, LithuaniaThe Clinic of Rheumatology, Traumatology Orthopaedics and Reconstructive Surgery, Institute of Clinical Medicine of the Faculty of Vilnius University, M. K. Čiurlionio Str. 21, 03101 Vilnius, Lithuania<i>Background and Objectives</i>: About 40% of early undifferentiated arthritis (UA) progresses to rheumatoid (RA) or other chronic arthritis. Novel diagnostic tools predicting the risk for this progression are needed to identify the patients who would benefit from early aggressive treatment. Evidence on the role of single-nucleotide polymorphisms (SNPs) in the development of RA has emerged. The aim of our study was to investigate the association between rs2476601, rs833070, and rs6920220 SNPs and UA progression to RA. <i>Materials and Methods</i>: Ninety-two UA patients were observed for 12 months. At study entry, demographic and clinical characteristics were recorded, musculoskeletal ultrasonography was performed, and blood samples were drawn to investigate levels of inflammatory markers, rheumatoid factor (RF), anti-citrullinated protein antibodies (anti-CCP)detect SNPs. After 12 months, UA outcomes were assessed, and patients were divided into two (RA and non-RA) groups. The association between the risk of progression to chronic inflammatory arthritis and analyzed SNPs was measured by computing odds ratios (OR). <i>Results</i>: After a 12-month follow-up, 27 (29.3%) patients developed RA, and 65 (70.7%) patients were assigned to the non-RA group. The arthritis of 21 patients (22.8%) from the non-RA group resolved completely, while the other 44 (47.2%) patients were diagnosed with another rheumatic inflammatory disease. The patients who developed RA had a significantly greater number of tender and swollen joints (<i>p</i> = 0.010 and <i>p</i> = 0.021 respectively) and were more frequently RF or anti-CCP (<i>p</i> < 0.001), and both RF and anti-CCP positive (<i>p</i> < 0.001) at the baseline as compared with the patients in the non-RA group. No significant association between rs2476601 (OR = 0.99, <i>p</i> = 0.98), rs833070 (OR = 1.0, <i>p</i> = 0.97), and rs6920220 (OR = 0.48, <i>p</i> = 0.13) polymorphisms and the risk of developing RA were found. <i>Conclusions</i>: No association between analyzed SNPs and a greater risk to progress from UA to RA was confirmed, although patients with rs6920220 <i>AA</i> + <i>AG</i> genotypes had fewer tender joints at the disease onset.https://www.mdpi.com/1648-9144/59/10/1824rheumatoid arthritisearly undifferentiated arthritissingle-nucleotide polymorphisms |
| spellingShingle | Regina Sakalyte Sigita Stropuviene Gabija Jasionyte Loreta Bagdonaite Algirdas Venalis Association between <i>PYTPN22</i> rs2476601, <i>VEGF</i> rs833070, <i>TNFAIP3</i> rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study Medicina rheumatoid arthritis early undifferentiated arthritis single-nucleotide polymorphisms |
| title | Association between <i>PYTPN22</i> rs2476601, <i>VEGF</i> rs833070, <i>TNFAIP3</i> rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study |
| title_full | Association between <i>PYTPN22</i> rs2476601, <i>VEGF</i> rs833070, <i>TNFAIP3</i> rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study |
| title_fullStr | Association between <i>PYTPN22</i> rs2476601, <i>VEGF</i> rs833070, <i>TNFAIP3</i> rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study |
| title_full_unstemmed | Association between <i>PYTPN22</i> rs2476601, <i>VEGF</i> rs833070, <i>TNFAIP3</i> rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study |
| title_short | Association between <i>PYTPN22</i> rs2476601, <i>VEGF</i> rs833070, <i>TNFAIP3</i> rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study |
| title_sort | association between i pytpn22 i rs2476601 i vegf i rs833070 i tnfaip3 i rs6920220 polymorphisms and risk for rheumatoid arthritis in early undifferentiated arthritis patients a pilot study |
| topic | rheumatoid arthritis early undifferentiated arthritis single-nucleotide polymorphisms |
| url | https://www.mdpi.com/1648-9144/59/10/1824 |
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