microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy Monitoring
Given the high morbidity and mortality of cardiovascular diseases (CVDs), novel biomarkers for platelet reactivity are urgently needed. Ischemic events in CVDs are causally linked to platelets, small anucleate cells important for hemostasis. The major side-effect of antiplatelet therapy are life-thr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/10/3477 |
| _version_ | 1797567964511207424 |
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| author | Teresa L. Krammer Manuel Mayr Matthias Hackl |
| author_facet | Teresa L. Krammer Manuel Mayr Matthias Hackl |
| author_sort | Teresa L. Krammer |
| collection | DOAJ |
| description | Given the high morbidity and mortality of cardiovascular diseases (CVDs), novel biomarkers for platelet reactivity are urgently needed. Ischemic events in CVDs are causally linked to platelets, small anucleate cells important for hemostasis. The major side-effect of antiplatelet therapy are life-threatening bleeding events. Current platelet function tests are not sufficient in guiding treatment decisions. Platelets host a broad spectrum of microRNAs (miRNAs) and are a major source of cell-free miRNAs in the blood stream. Platelet-related miRNAs have been suggested as biomarkers of platelet activation and assessment of antiplatelet therapy responsiveness. Platelets release miRNAs upon activation, possibly leading to alterations of plasma miRNA levels in conjunction with CVD or inadequate platelet inhibition. Unlike current platelet function tests, which measure platelet activation ex vivo, signatures of platelet-related miRNAs potentially enable the assessment of in vivo platelet reactivity. Evidence suggests that some miRNAs are responsive to platelet inhibition, making them promising biomarker candidates. In this review, we explain the secretion of miRNAs upon platelet activation and discuss the potential use of platelet-related miRNAs as biomarkers for CVD and antiplatelet therapy monitoring, but also highlight remaining gaps in our knowledge and uncertainties regarding clinical utility. We also elaborate on technical issues and limitations concerning plasma miRNA quantification. |
| first_indexed | 2024-03-10T19:49:40Z |
| format | Article |
| id | doaj.art-71df4155c032425fb1d7bebdf13e599f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:49:40Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-71df4155c032425fb1d7bebdf13e599f2023-11-20T00:29:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110347710.3390/ijms21103477microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy MonitoringTeresa L. Krammer0Manuel Mayr1Matthias Hackl2TAmiRNA GmbH, 1110 Vienna, AustriaKing’s British Heart Foundation Centre, King’s College London, London SE5 9NU, UKTAmiRNA GmbH, 1110 Vienna, AustriaGiven the high morbidity and mortality of cardiovascular diseases (CVDs), novel biomarkers for platelet reactivity are urgently needed. Ischemic events in CVDs are causally linked to platelets, small anucleate cells important for hemostasis. The major side-effect of antiplatelet therapy are life-threatening bleeding events. Current platelet function tests are not sufficient in guiding treatment decisions. Platelets host a broad spectrum of microRNAs (miRNAs) and are a major source of cell-free miRNAs in the blood stream. Platelet-related miRNAs have been suggested as biomarkers of platelet activation and assessment of antiplatelet therapy responsiveness. Platelets release miRNAs upon activation, possibly leading to alterations of plasma miRNA levels in conjunction with CVD or inadequate platelet inhibition. Unlike current platelet function tests, which measure platelet activation ex vivo, signatures of platelet-related miRNAs potentially enable the assessment of in vivo platelet reactivity. Evidence suggests that some miRNAs are responsive to platelet inhibition, making them promising biomarker candidates. In this review, we explain the secretion of miRNAs upon platelet activation and discuss the potential use of platelet-related miRNAs as biomarkers for CVD and antiplatelet therapy monitoring, but also highlight remaining gaps in our knowledge and uncertainties regarding clinical utility. We also elaborate on technical issues and limitations concerning plasma miRNA quantification.https://www.mdpi.com/1422-0067/21/10/3477microRNAplateletsbiomarkerantiplatelet therapyplatelet activationcirculating microRNAs |
| spellingShingle | Teresa L. Krammer Manuel Mayr Matthias Hackl microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy Monitoring International Journal of Molecular Sciences microRNA platelets biomarker antiplatelet therapy platelet activation circulating microRNAs |
| title | microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy Monitoring |
| title_full | microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy Monitoring |
| title_fullStr | microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy Monitoring |
| title_full_unstemmed | microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy Monitoring |
| title_short | microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy Monitoring |
| title_sort | micrornas as promising biomarkers of platelet activity in antiplatelet therapy monitoring |
| topic | microRNA platelets biomarker antiplatelet therapy platelet activation circulating microRNAs |
| url | https://www.mdpi.com/1422-0067/21/10/3477 |
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