Platelet Endothelial Cell Adhesion Molecule 1 (CD31) Is Essential for <i>Clostridium perfringens</i> Beta-Toxin Mediated Cytotoxicity in Human Endothelial and Monocytic Cells

Platelet Endothelial Cell Adhesion Molecule 1 (CD31) Is Essential for <i>Clostridium perfringens</i> Beta-Toxin Mediated Cytotoxicity in Human Endothelial and Monocytic Cells

Beta toxin (CPB) is a small hemolysin beta pore-forming toxin (β-PFT) produced by <i>Clostridium perfringens</i> type C. It plays a central role in the pathogenesis of necro-hemorrhagic enteritis in young animals and humans via targeting intestinal endothelial cells. We recently identifi...

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Bibliographic Details
Main Authors: Basma Tarek, Julia Bruggisser, Filippo Cattalani, Horst Posthaus
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Toxins
Subjects:
PECAM-1
CD31
<i>Clostridium perfringens</i>
beta-toxin
pore forming toxin
membrane receptor
Online Access:https://www.mdpi.com/2072-6651/13/12/893

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