Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival

Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival

Background Glioblastoma (GBM), a highly immunosuppressive and often fatal primary brain tumor, lacks effective treatment options. GBMs contain a subpopulation of GBM stem-like cells (GSCs) that play a central role in tumor initiation, progression, and treatment resistance. Oncolytic viruses, especia...

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Bibliographic Details
Main Authors:	Howard L Kaufman, Dipongkor Saha, Samuel D Rabkin, Robert L Martuza, Praveen K Bommareddy, Hiroaki Wakimoto
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2024-04-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/12/4/e008880.full

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