An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplification
An ultra-sensitive phase plasmonic sensor combined with weak value amplification is proposed for the detection of IgG, as a model analyte. Phase detection is accomplished by self-interference between the p-polarization and the s-polarization of the light. With the principles of weak value amplificat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2024.1382251/full |
| _version_ | 1797269047215128576 |
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| author | Lizhong Zhang Mingyi He Yang Xu Cuixia Guo Chongqi Zhou Chongqi Zhou Tian Guan |
| author_facet | Lizhong Zhang Mingyi He Yang Xu Cuixia Guo Chongqi Zhou Chongqi Zhou Tian Guan |
| author_sort | Lizhong Zhang |
| collection | DOAJ |
| description | An ultra-sensitive phase plasmonic sensor combined with weak value amplification is proposed for the detection of IgG, as a model analyte. Phase detection is accomplished by self-interference between the p-polarization and the s-polarization of the light. With the principles of weak value amplification, a phase compensator is used to modulate the coupling strength and enhance the refractive index sensitivity of the system. On a simple Au-coated prism-coupled surface plasmon resonance (SPR) structure, the scheme, called WMSPR, achieves a refractive index sensitivity of 4.737 × 104 nm/RIU, which is about three times higher than that of the conventional phase-based approach. The proposed WMSPR biosensor gives great characteristics with a high resolution of 6.333 × 10−8 RIU and a low limit of detection (LOD) of 5.3 ng/mL. The results yield a great scope to promote the optimization of other SPR biosensors for high sensitivity. |
| first_indexed | 2024-04-25T01:42:09Z |
| format | Article |
| id | doaj.art-71dfbd411efb48148287e567172dba42 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-25T01:42:09Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-71dfbd411efb48148287e567172dba422024-03-08T04:38:43ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462024-03-011210.3389/fchem.2024.13822511382251An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplificationLizhong Zhang0Mingyi He1Yang Xu2Cuixia Guo3Chongqi Zhou4Chongqi Zhou5Tian Guan6Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen International Graduate School, Tsinghua University, Shenzhen, ChinaSchool of International Education, Beijing University of Chemical Technology, Beijing, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen International Graduate School, Tsinghua University, Shenzhen, ChinaSchool of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, Fujian Province, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen International Graduate School, Tsinghua University, Shenzhen, ChinaDepartment of Physics, Tsinghua University, Beijing, ChinaInstitute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen International Graduate School, Tsinghua University, Shenzhen, ChinaAn ultra-sensitive phase plasmonic sensor combined with weak value amplification is proposed for the detection of IgG, as a model analyte. Phase detection is accomplished by self-interference between the p-polarization and the s-polarization of the light. With the principles of weak value amplification, a phase compensator is used to modulate the coupling strength and enhance the refractive index sensitivity of the system. On a simple Au-coated prism-coupled surface plasmon resonance (SPR) structure, the scheme, called WMSPR, achieves a refractive index sensitivity of 4.737 × 104 nm/RIU, which is about three times higher than that of the conventional phase-based approach. The proposed WMSPR biosensor gives great characteristics with a high resolution of 6.333 × 10−8 RIU and a low limit of detection (LOD) of 5.3 ng/mL. The results yield a great scope to promote the optimization of other SPR biosensors for high sensitivity.https://www.frontiersin.org/articles/10.3389/fchem.2024.1382251/fullweak value amplificationsurface plasmon resonancerefractive index sensorbiosensorbiomolecular interaction |
| spellingShingle | Lizhong Zhang Mingyi He Yang Xu Cuixia Guo Chongqi Zhou Chongqi Zhou Tian Guan An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplification Frontiers in Chemistry weak value amplification surface plasmon resonance refractive index sensor biosensor biomolecular interaction |
| title | An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplification |
| title_full | An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplification |
| title_fullStr | An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplification |
| title_full_unstemmed | An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplification |
| title_short | An ultra-sensitive biosensor based on surface plasmon resonance and weak value amplification |
| title_sort | ultra sensitive biosensor based on surface plasmon resonance and weak value amplification |
| topic | weak value amplification surface plasmon resonance refractive index sensor biosensor biomolecular interaction |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1382251/full |
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