Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study
Purpose: Brain areas frequently implicated in language recovery after stroke comprise perilesional sites in the left hemisphere and homotopic regions in the right hemisphere. However, the neuronal mechanisms underlying language restoration are still largely unclear. Methods and materials: In the pre...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/2/300 |
| _version_ | 1827758246105972736 |
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| author | Haozheng Li Hui Zhang Shuai Xu Mengxing Wang Jilei Zhang Jianren Liu Xiaoxia Du Ruiping Hu |
| author_facet | Haozheng Li Hui Zhang Shuai Xu Mengxing Wang Jilei Zhang Jianren Liu Xiaoxia Du Ruiping Hu |
| author_sort | Haozheng Li |
| collection | DOAJ |
| description | Purpose: Brain areas frequently implicated in language recovery after stroke comprise perilesional sites in the left hemisphere and homotopic regions in the right hemisphere. However, the neuronal mechanisms underlying language restoration are still largely unclear. Methods and materials: In the present study, we investigated the brain function in 15 patients with poststroke aphasia and 30 matched control subjects by combining the regional homogeneity (ReHo) and amplitudes of low-frequency fluctuation (ALFF) analysis methods based on resting-state fMRI. Results: Compared to the control subjects, the patients with aphasia exhibited increased ReHo and ALFF values in the ipsilateral perilesional areas and increased ReHo in the contralesional right middle frontal gyrus. Conclusions: The increased spontaneous brain activity in patients with poststroke aphasia during the recovery period, specifically in the ipsilateral perilesional regions and the homologous language regions of the right hemisphere, has potential implications for the treatment of patients with aphasia. |
| first_indexed | 2024-03-11T09:04:06Z |
| format | Article |
| id | doaj.art-71e1c6bdb5084542b231f5b71c3094d3 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T09:04:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj.art-71e1c6bdb5084542b231f5b71c3094d32023-11-16T19:29:05ZengMDPI AGBrain Sciences2076-34252023-02-0113230010.3390/brainsci13020300Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI StudyHaozheng Li0Hui Zhang1Shuai Xu2Mengxing Wang3Jilei Zhang4Jianren Liu5Xiaoxia Du6Ruiping Hu7Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, ChinaShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, ChinaShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, ChinaShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai 200062, ChinaDepartment of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaDepartment of Psychology, Shanghai University of Sport, Shanghai 200438, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, ChinaPurpose: Brain areas frequently implicated in language recovery after stroke comprise perilesional sites in the left hemisphere and homotopic regions in the right hemisphere. However, the neuronal mechanisms underlying language restoration are still largely unclear. Methods and materials: In the present study, we investigated the brain function in 15 patients with poststroke aphasia and 30 matched control subjects by combining the regional homogeneity (ReHo) and amplitudes of low-frequency fluctuation (ALFF) analysis methods based on resting-state fMRI. Results: Compared to the control subjects, the patients with aphasia exhibited increased ReHo and ALFF values in the ipsilateral perilesional areas and increased ReHo in the contralesional right middle frontal gyrus. Conclusions: The increased spontaneous brain activity in patients with poststroke aphasia during the recovery period, specifically in the ipsilateral perilesional regions and the homologous language regions of the right hemisphere, has potential implications for the treatment of patients with aphasia.https://www.mdpi.com/2076-3425/13/2/300poststroke aphasiafunctional magnetic resonance imagingregional homogeneitylow-frequency fluctuationbrain function |
| spellingShingle | Haozheng Li Hui Zhang Shuai Xu Mengxing Wang Jilei Zhang Jianren Liu Xiaoxia Du Ruiping Hu Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study Brain Sciences poststroke aphasia functional magnetic resonance imaging regional homogeneity low-frequency fluctuation brain function |
| title | Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study |
| title_full | Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study |
| title_fullStr | Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study |
| title_full_unstemmed | Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study |
| title_short | Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study |
| title_sort | altered spontaneous brain activity in poststroke aphasia a resting state fmri study |
| topic | poststroke aphasia functional magnetic resonance imaging regional homogeneity low-frequency fluctuation brain function |
| url | https://www.mdpi.com/2076-3425/13/2/300 |
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