The effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmission
Abstract To evaluate the efficiency of a 20 μg hepatitis B vaccine(HepB) for disease prevention in two counties in Henan Province, China. A questionnaire was designed to examine the information of hepatitis B surface antigen (HBsAg) positive pregnant women, and their blood samples were collected to...
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| Format: | Article |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15744-z |
| _version_ | 1818196948737327104 |
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| author | Guo Yonghao Chen Yanping Dou Qiaohua Feng Daxing Zhang Yanyang Zhao Dongyang Guo Wanshen |
| author_facet | Guo Yonghao Chen Yanping Dou Qiaohua Feng Daxing Zhang Yanyang Zhao Dongyang Guo Wanshen |
| author_sort | Guo Yonghao |
| collection | DOAJ |
| description | Abstract To evaluate the efficiency of a 20 μg hepatitis B vaccine(HepB) for disease prevention in two counties in Henan Province, China. A questionnaire was designed to examine the information of hepatitis B surface antigen (HBsAg) positive pregnant women, and their blood samples were collected to test for hepatitis B e antigen (HBeAg), hepatitis B e antibody, and hepatitis B virus (HBV) DNA. Three doses of 20 μg HepB and one dose of hepatitis B immune globulin(HBIG) were administered to newborns. Blood samples were collected from children one month after their complete immunization to test for HBsAg and hepatitis B surface antibody(HBsAb). A total of 419 HBsAg positive-pregnant women and 430 newborns were investigated. The average age of pregnant women was 29.6 ± 4.3 years, with an HBeAg positive rate of 29.1% (122/419). All newborns received their first dose of 20 μg hepatitis B vaccine and 100 IU HBIG within 12 h after birth. Six infants (1.9%, 6/319) tested positive for HBsAg and negative for HBsAb after one month of receiving the three basic doses of HepB. The geometric mean concentration(GMC) of HBsAb-positive infants was 861.6 mIU/mL, and their HBsAb antibody titers decreased with age. Immunization of children born to HBsAg-positive mothers with 20 μg HepB got the satisfactory effect on preventing mother-to-child transmission. |
| first_indexed | 2024-12-12T01:42:12Z |
| format | Article |
| id | doaj.art-71e21409ad6640f38c9da96bafb53096 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T01:42:12Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-71e21409ad6640f38c9da96bafb530962022-12-22T00:42:41ZengNature PortfolioScientific Reports2045-23222022-07-011211810.1038/s41598-022-15744-zThe effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmissionGuo Yonghao0Chen Yanping1Dou Qiaohua2Feng Daxing3Zhang Yanyang4Zhao Dongyang5Guo Wanshen6Henan Provincial Center for Disease Control and PreventionCollege of Public Health, Zhengzhou UniversityHenan Provincial Center for Disease Control and PreventionHenan Provincial Center for Disease Control and PreventionHenan Provincial Center for Disease Control and PreventionHenan Provincial Center for Disease Control and PreventionHenan Provincial Center for Disease Control and PreventionAbstract To evaluate the efficiency of a 20 μg hepatitis B vaccine(HepB) for disease prevention in two counties in Henan Province, China. A questionnaire was designed to examine the information of hepatitis B surface antigen (HBsAg) positive pregnant women, and their blood samples were collected to test for hepatitis B e antigen (HBeAg), hepatitis B e antibody, and hepatitis B virus (HBV) DNA. Three doses of 20 μg HepB and one dose of hepatitis B immune globulin(HBIG) were administered to newborns. Blood samples were collected from children one month after their complete immunization to test for HBsAg and hepatitis B surface antibody(HBsAb). A total of 419 HBsAg positive-pregnant women and 430 newborns were investigated. The average age of pregnant women was 29.6 ± 4.3 years, with an HBeAg positive rate of 29.1% (122/419). All newborns received their first dose of 20 μg hepatitis B vaccine and 100 IU HBIG within 12 h after birth. Six infants (1.9%, 6/319) tested positive for HBsAg and negative for HBsAb after one month of receiving the three basic doses of HepB. The geometric mean concentration(GMC) of HBsAb-positive infants was 861.6 mIU/mL, and their HBsAb antibody titers decreased with age. Immunization of children born to HBsAg-positive mothers with 20 μg HepB got the satisfactory effect on preventing mother-to-child transmission.https://doi.org/10.1038/s41598-022-15744-z |
| spellingShingle | Guo Yonghao Chen Yanping Dou Qiaohua Feng Daxing Zhang Yanyang Zhao Dongyang Guo Wanshen The effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmission Scientific Reports |
| title | The effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmission |
| title_full | The effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmission |
| title_fullStr | The effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmission |
| title_full_unstemmed | The effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmission |
| title_short | The effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmission |
| title_sort | effectiveness of 20 μg hepatitis b vaccine used for the prevention of hbv vertical transmission |
| url | https://doi.org/10.1038/s41598-022-15744-z |
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