Endogenous glucocorticoids in inflammation: contributions of systemic and local responses
The anti-inflammatory actions of therapeutic glucocorticoids are well established and these drugs are widely used to treat a variety of inflammatory conditions. It is also clear that endogenously synthesised glucocorticoids have an important role in regulating inflammatory responses. Tradition...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2012-07-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/1551 |
| _version_ | 1811194158313897984 |
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| author | Rowan S. Hardy Karim Raza Mark S. Cooper |
| author_facet | Rowan S. Hardy Karim Raza Mark S. Cooper |
| author_sort | Rowan S. Hardy |
| collection | DOAJ |
| description |
The anti-inflammatory actions of therapeutic glucocorticoids are well established and these drugs are widely used to treat a variety of inflammatory conditions. It is also clear that endogenously synthesised glucocorticoids have an important role in regulating inflammatory responses. Traditionally, our understanding of the effects of endogenous glucocorticoids has been based on the levels of glucocorticoids within the circulation. These levels are controlled by the hypothalamic-pituitary-adrenal axis. However, more recently it has been established that the local level of glucocorticoids is of potential importance. Situations where the local level of glucocorticoids may differ from the level in the circulation are illustrated in this review. In addition, the mechanisms regulating local glucocorticoid levels and actions are identified. Increasingly, it will be important to understand how the levels of glucocorticoids within the circulation and within the tissues are regulated in a coordinated manner.
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| first_indexed | 2024-04-12T00:21:14Z |
| format | Article |
| id | doaj.art-71e27b4c47f04cb38e17465056181bd5 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-12T00:21:14Z |
| publishDate | 2012-07-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-71e27b4c47f04cb38e17465056181bd52022-12-22T03:55:43ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972012-07-01142313210.4414/smw.2012.13650Endogenous glucocorticoids in inflammation: contributions of systemic and local responsesRowan S. HardyKarim RazaMark S. Cooper The anti-inflammatory actions of therapeutic glucocorticoids are well established and these drugs are widely used to treat a variety of inflammatory conditions. It is also clear that endogenously synthesised glucocorticoids have an important role in regulating inflammatory responses. Traditionally, our understanding of the effects of endogenous glucocorticoids has been based on the levels of glucocorticoids within the circulation. These levels are controlled by the hypothalamic-pituitary-adrenal axis. However, more recently it has been established that the local level of glucocorticoids is of potential importance. Situations where the local level of glucocorticoids may differ from the level in the circulation are illustrated in this review. In addition, the mechanisms regulating local glucocorticoid levels and actions are identified. Increasingly, it will be important to understand how the levels of glucocorticoids within the circulation and within the tissues are regulated in a coordinated manner. https://www.smw.ch/index.php/smw/article/view/155111beta-hydroxysteroid dehydrogenasecortisolglucocorticoidsinflammation |
| spellingShingle | Rowan S. Hardy Karim Raza Mark S. Cooper Endogenous glucocorticoids in inflammation: contributions of systemic and local responses Swiss Medical Weekly 11beta-hydroxysteroid dehydrogenase cortisol glucocorticoids inflammation |
| title | Endogenous glucocorticoids in inflammation: contributions of systemic and local responses |
| title_full | Endogenous glucocorticoids in inflammation: contributions of systemic and local responses |
| title_fullStr | Endogenous glucocorticoids in inflammation: contributions of systemic and local responses |
| title_full_unstemmed | Endogenous glucocorticoids in inflammation: contributions of systemic and local responses |
| title_short | Endogenous glucocorticoids in inflammation: contributions of systemic and local responses |
| title_sort | endogenous glucocorticoids in inflammation contributions of systemic and local responses |
| topic | 11beta-hydroxysteroid dehydrogenase cortisol glucocorticoids inflammation |
| url | https://www.smw.ch/index.php/smw/article/view/1551 |
| work_keys_str_mv | AT rowanshardy endogenousglucocorticoidsininflammationcontributionsofsystemicandlocalresponses AT karimraza endogenousglucocorticoidsininflammationcontributionsofsystemicandlocalresponses AT markscooper endogenousglucocorticoidsininflammationcontributionsofsystemicandlocalresponses |