Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC
Strophanthus sarmentosus DC is used traditionally in the management of snake-bite, arthritis, eye infection, rheumatism, emetic and venereal diseases. Freshly collected mature Strophanthus sarmentosus plant parts were air-dried at room temperature. Each of the plant parts (leaf, stem and roots) was...
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| Format: | Article |
| Language: | English |
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State Islamic University Sunan Kalijaga
2023-01-01
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| Series: | Biology, Medicine & Natural Product Chemistry |
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| Online Access: | https://sciencebiology.org/index.php/BIOMEDICH/article/view/286 |
| _version_ | 1797744204852494336 |
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| author | Julius Leke Abiola Olapeju Oluyemisi Aiyelaagbe |
| author_facet | Julius Leke Abiola Olapeju Oluyemisi Aiyelaagbe |
| author_sort | Julius Leke Abiola |
| collection | DOAJ |
| description | Strophanthus sarmentosus DC is used traditionally in the management of snake-bite, arthritis, eye infection, rheumatism, emetic and venereal diseases. Freshly collected mature Strophanthus sarmentosus plant parts were air-dried at room temperature. Each of the plant parts (leaf, stem and roots) was successively extracted by cold extraction method using hexane, ethyl acetate and methanol respectively. The crude extracts were subjected to phytochemical, antimicrobial and cytotoxicity analysis by employing chemical tests, agar diffusion and brine shrimps methods.
The phytochemical screening showed the presence of tannins, saponins, glycosides, flavonoids, phenols, steroids, terpenoids and carbohydrates in all the extracts. The extracts demonstrated broad spectrum activities against both gram- positive and gram-negative bacteria and the fungi tested. The MIC and MMC of ethyl acetate and methanol extracts of the S. sarmentosus (stem) is between 0.3 and 5.0 mg/mL. The cytotoxic activity (LC50) of the S. sarmentosus extracts (leaf, stem and root) ranged between 117 µg/mL and 270 µg/mL, showing that the extracts are within the medium toxic level according to Clarkson’s toxicity index. |
| first_indexed | 2024-03-12T15:06:23Z |
| format | Article |
| id | doaj.art-71e3085c65bb45a392d1160d1113a7a5 |
| institution | Directory Open Access Journal |
| issn | 2089-6514 2540-9328 |
| language | English |
| last_indexed | 2024-03-12T15:06:23Z |
| publishDate | 2023-01-01 |
| publisher | State Islamic University Sunan Kalijaga |
| record_format | Article |
| series | Biology, Medicine & Natural Product Chemistry |
| spelling | doaj.art-71e3085c65bb45a392d1160d1113a7a52023-08-12T13:11:07ZengState Islamic University Sunan KalijagaBiology, Medicine & Natural Product Chemistry2089-65142540-93282023-01-0112111912610.14421/biomedich.2023.121.119-126160Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DCJulius Leke Abiola0Olapeju Oluyemisi Aiyelaagbe1Department of Chemistry, University of Ibadan, Oyo State.Department of Chemistry, University of Ibadan, Oyo StateStrophanthus sarmentosus DC is used traditionally in the management of snake-bite, arthritis, eye infection, rheumatism, emetic and venereal diseases. Freshly collected mature Strophanthus sarmentosus plant parts were air-dried at room temperature. Each of the plant parts (leaf, stem and roots) was successively extracted by cold extraction method using hexane, ethyl acetate and methanol respectively. The crude extracts were subjected to phytochemical, antimicrobial and cytotoxicity analysis by employing chemical tests, agar diffusion and brine shrimps methods. The phytochemical screening showed the presence of tannins, saponins, glycosides, flavonoids, phenols, steroids, terpenoids and carbohydrates in all the extracts. The extracts demonstrated broad spectrum activities against both gram- positive and gram-negative bacteria and the fungi tested. The MIC and MMC of ethyl acetate and methanol extracts of the S. sarmentosus (stem) is between 0.3 and 5.0 mg/mL. The cytotoxic activity (LC50) of the S. sarmentosus extracts (leaf, stem and root) ranged between 117 µg/mL and 270 µg/mL, showing that the extracts are within the medium toxic level according to Clarkson’s toxicity index.https://sciencebiology.org/index.php/BIOMEDICH/article/view/286antimicrobial activity, cytotoxic activity, strophanthus sarmentos dc, apocyanaceae, phytochemicals, |
| spellingShingle | Julius Leke Abiola Olapeju Oluyemisi Aiyelaagbe Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC Biology, Medicine & Natural Product Chemistry antimicrobial activity, cytotoxic activity, strophanthus sarmentos dc, apocyanaceae, phytochemicals, |
| title | Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC |
| title_full | Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC |
| title_fullStr | Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC |
| title_full_unstemmed | Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC |
| title_short | Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC |
| title_sort | phytochemical antimicrobial and cytotoxic activities of strophanthus sarmentosus dc |
| topic | antimicrobial activity, cytotoxic activity, strophanthus sarmentos dc, apocyanaceae, phytochemicals, |
| url | https://sciencebiology.org/index.php/BIOMEDICH/article/view/286 |
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