Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controls
The composition of the gut microbiota in patients with anorexia nervosa (AN), and the ability of this microbial community to influence the host, remains uncertain. To achieve a broader understanding of the role of the intestinal microbiota in patients with AN, we collected fecal samples before and f...
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2143217 |
| _version_ | 1797983757799522304 |
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| author | Farnaz Fouladi Emily C. Bulik-Sullivan Elaine M. Glenny Laura M. Thornton Kylie K. Reed Stephanie Thomas Susan Kleiman Ashlie Watters Judy Oakes Eun-Young Huh Quyen Tang Jintong Liu Zorka Djukic Lauren Harper Yesel Trillo-Ordoñez Shan Sun Ivory Blakely Philip S. Mehler Anthony A. Fodor Lisa M. Tarantino Cynthia M. Bulik Ian M. Carroll |
| author_facet | Farnaz Fouladi Emily C. Bulik-Sullivan Elaine M. Glenny Laura M. Thornton Kylie K. Reed Stephanie Thomas Susan Kleiman Ashlie Watters Judy Oakes Eun-Young Huh Quyen Tang Jintong Liu Zorka Djukic Lauren Harper Yesel Trillo-Ordoñez Shan Sun Ivory Blakely Philip S. Mehler Anthony A. Fodor Lisa M. Tarantino Cynthia M. Bulik Ian M. Carroll |
| author_sort | Farnaz Fouladi |
| collection | DOAJ |
| description | The composition of the gut microbiota in patients with anorexia nervosa (AN), and the ability of this microbial community to influence the host, remains uncertain. To achieve a broader understanding of the role of the intestinal microbiota in patients with AN, we collected fecal samples before and following clinical treatment at two geographically distinct eating disorder units (Center of Excellence for Eating Disorders [UNC-CH] and ACUTE Center for Eating Disorders [Denver Health]). Gut microbiotas were characterized in patients with AN, before and after inpatient treatment, and in non-eating disorder (non-ED) controls using shotgun metagenomic sequencing. The impact of inpatient treatment on the AN gut microbiota was remarkably consistent between eating disorder units. Although weight in patients with AN showed improvements, AN microbiotas post-treatment remained distinct from non-ED controls. Additionally, AN gut microbiotas prior to treatment exhibited more fermentation pathways and a lower ability to degrade carbohydrates than non-ED controls. As the intestinal microbiota can influence nutrient metabolism, our data highlight the complex microbial communities in patients with AN as an element needing further attention post inpatient treatment. Additionally, this study defines the effects of renourishment on the AN gut microbiota and serves as a platform to develop precision nutrition approaches to potentially mitigate impediments to recovery. |
| first_indexed | 2024-04-11T06:51:10Z |
| format | Article |
| id | doaj.art-71e3b32bfafb4406ac607ed4da4d89a6 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-11T06:51:10Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-71e3b32bfafb4406ac607ed4da4d89a62022-12-22T04:39:10ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2143217Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controlsFarnaz Fouladi0Emily C. Bulik-Sullivan1Elaine M. Glenny2Laura M. Thornton3Kylie K. Reed4Stephanie Thomas5Susan Kleiman6Ashlie Watters7Judy Oakes8Eun-Young Huh9Quyen Tang10Jintong Liu11Zorka Djukic12Lauren Harper13Yesel Trillo-Ordoñez14Shan Sun15Ivory Blakely16Philip S. Mehler17Anthony A. Fodor18Lisa M. Tarantino19Cynthia M. Bulik20Ian M. Carroll21Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC 28223, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, University of Colorado School of Medicine, Denver, CO 80204, USAACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, Department of Medicine, Medical Intensive Care Unit, Denver Health Hospital Authority, Denver, CO 80204, USACenter for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAGraduate School of Professional Psychology, Morrison Family College of Health, University of St. Thomas, Minneapolis, MN, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USACenter for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC 28223, USADepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC 28223, USAACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, University of Colorado School of Medicine, Denver, CO 80204, USADepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC 28223, USADepartment of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAThe composition of the gut microbiota in patients with anorexia nervosa (AN), and the ability of this microbial community to influence the host, remains uncertain. To achieve a broader understanding of the role of the intestinal microbiota in patients with AN, we collected fecal samples before and following clinical treatment at two geographically distinct eating disorder units (Center of Excellence for Eating Disorders [UNC-CH] and ACUTE Center for Eating Disorders [Denver Health]). Gut microbiotas were characterized in patients with AN, before and after inpatient treatment, and in non-eating disorder (non-ED) controls using shotgun metagenomic sequencing. The impact of inpatient treatment on the AN gut microbiota was remarkably consistent between eating disorder units. Although weight in patients with AN showed improvements, AN microbiotas post-treatment remained distinct from non-ED controls. Additionally, AN gut microbiotas prior to treatment exhibited more fermentation pathways and a lower ability to degrade carbohydrates than non-ED controls. As the intestinal microbiota can influence nutrient metabolism, our data highlight the complex microbial communities in patients with AN as an element needing further attention post inpatient treatment. Additionally, this study defines the effects of renourishment on the AN gut microbiota and serves as a platform to develop precision nutrition approaches to potentially mitigate impediments to recovery.https://www.tandfonline.com/doi/10.1080/19490976.2022.2143217Intestinal microbiotaanorexia nervosarenourishmentnutrition |
| spellingShingle | Farnaz Fouladi Emily C. Bulik-Sullivan Elaine M. Glenny Laura M. Thornton Kylie K. Reed Stephanie Thomas Susan Kleiman Ashlie Watters Judy Oakes Eun-Young Huh Quyen Tang Jintong Liu Zorka Djukic Lauren Harper Yesel Trillo-Ordoñez Shan Sun Ivory Blakely Philip S. Mehler Anthony A. Fodor Lisa M. Tarantino Cynthia M. Bulik Ian M. Carroll Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controls Gut Microbes Intestinal microbiota anorexia nervosa renourishment nutrition |
| title | Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controls |
| title_full | Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controls |
| title_fullStr | Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controls |
| title_full_unstemmed | Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controls |
| title_short | Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controls |
| title_sort | reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non eating disorder controls |
| topic | Intestinal microbiota anorexia nervosa renourishment nutrition |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2143217 |
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