FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients
Abstract Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coron...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2021-09-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000600101&tlng=en |
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| author | Valentina V. Miroshnikova Ekaterina A. Polyakova Irina A. Pobozheva Aleksandra A. Panteleeva Natalia D. Razgildina Diana A. Kolodina Olga D. Belyaeva Olga A. Berkovich Sofya N. Pchelina Elena I. Baranova |
| author_facet | Valentina V. Miroshnikova Ekaterina A. Polyakova Irina A. Pobozheva Aleksandra A. Panteleeva Natalia D. Razgildina Diana A. Kolodina Olga D. Belyaeva Olga A. Berkovich Sofya N. Pchelina Elena I. Baranova |
| author_sort | Valentina V. Miroshnikova |
| collection | DOAJ |
| description | Abstract Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD. |
| first_indexed | 2024-12-18T02:46:19Z |
| format | Article |
| id | doaj.art-71e4399f8ef2416aa7ed3a7da7b6a719 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-18T02:46:19Z |
| publishDate | 2021-09-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-71e4399f8ef2416aa7ed3a7da7b6a7192022-12-21T21:23:34ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852021-09-0144410.1590/1678-4685-gmb-2020-0441FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patientsValentina V. Miroshnikovahttps://orcid.org/0000-0003-3160-2314Ekaterina A. PolyakovaIrina A. PobozhevaAleksandra A. PanteleevaNatalia D. RazgildinaDiana A. KolodinaOlga D. BelyaevaOlga A. BerkovichSofya N. PchelinaElena I. BaranovaAbstract Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000600101&tlng=enCoronary artery diseaseepicardial adipose tissuesubcutaneous adipose tissueFABP4omentin-1 |
| spellingShingle | Valentina V. Miroshnikova Ekaterina A. Polyakova Irina A. Pobozheva Aleksandra A. Panteleeva Natalia D. Razgildina Diana A. Kolodina Olga D. Belyaeva Olga A. Berkovich Sofya N. Pchelina Elena I. Baranova FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients Genetics and Molecular Biology Coronary artery disease epicardial adipose tissue subcutaneous adipose tissue FABP4 omentin-1 |
| title | FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients |
| title_full | FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients |
| title_fullStr | FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients |
| title_full_unstemmed | FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients |
| title_short | FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients |
| title_sort | fabp4 and omentin 1 gene expression in epicardial adipose tissue from coronary artery disease patients |
| topic | Coronary artery disease epicardial adipose tissue subcutaneous adipose tissue FABP4 omentin-1 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572021000600101&tlng=en |
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