Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?
Stroke-induced cognitive impairments affect the long-term quality of life. High-intensity interval training (HIIT) is now considered a promising strategy to enhance cognitive functions. This review is designed to examine the role of HIIT in promoting neuroplasticity processes and/or cognitive functi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/3003 |
| _version_ | 1797541251531145216 |
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| author | Nicolas Hugues Christophe Pellegrino Claudio Rivera Eric Berton Caroline Pin-Barre Jérôme Laurin |
| author_facet | Nicolas Hugues Christophe Pellegrino Claudio Rivera Eric Berton Caroline Pin-Barre Jérôme Laurin |
| author_sort | Nicolas Hugues |
| collection | DOAJ |
| description | Stroke-induced cognitive impairments affect the long-term quality of life. High-intensity interval training (HIIT) is now considered a promising strategy to enhance cognitive functions. This review is designed to examine the role of HIIT in promoting neuroplasticity processes and/or cognitive functions after stroke. The various methodological limitations related to the clinical relevance of studies on the exercise recommendations in individuals with stroke are first discussed. Then, the relevance of HIIT in improving neurotrophic factors expression, neurogenesis and synaptic plasticity is debated in both stroke and healthy individuals (humans and rodents). Moreover, HIIT may have a preventive role on stroke severity, as found in rodents. The potential role of HIIT in stroke rehabilitation is reinforced by findings showing its powerful neurogenic effect that might potentiate cognitive benefits induced by cognitive tasks. In addition, the clinical role of neuroplasticity observed in each hemisphere needs to be clarified by coupling more frequently to cellular/molecular measurements and behavioral testing. |
| first_indexed | 2024-03-10T13:12:36Z |
| format | Article |
| id | doaj.art-71e6edc62a844b30a25638de3e3fd56f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:12:36Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-71e6edc62a844b30a25638de3e3fd56f2023-11-21T10:38:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226300310.3390/ijms22063003Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?Nicolas Hugues0Christophe Pellegrino1Claudio Rivera2Eric Berton3Caroline Pin-Barre4Jérôme Laurin5INMED, INSERM, Aix-Marseille University, 13007 Marseille, FranceINMED, INSERM, Aix-Marseille University, 13007 Marseille, FranceINMED, INSERM, Aix-Marseille University, 13007 Marseille, FranceCNRS, ISM, Aix-Marseille University, 13007 Marseille, FranceCNRS, ISM, Aix-Marseille University, 13007 Marseille, FranceINMED, INSERM, Aix-Marseille University, 13007 Marseille, FranceStroke-induced cognitive impairments affect the long-term quality of life. High-intensity interval training (HIIT) is now considered a promising strategy to enhance cognitive functions. This review is designed to examine the role of HIIT in promoting neuroplasticity processes and/or cognitive functions after stroke. The various methodological limitations related to the clinical relevance of studies on the exercise recommendations in individuals with stroke are first discussed. Then, the relevance of HIIT in improving neurotrophic factors expression, neurogenesis and synaptic plasticity is debated in both stroke and healthy individuals (humans and rodents). Moreover, HIIT may have a preventive role on stroke severity, as found in rodents. The potential role of HIIT in stroke rehabilitation is reinforced by findings showing its powerful neurogenic effect that might potentiate cognitive benefits induced by cognitive tasks. In addition, the clinical role of neuroplasticity observed in each hemisphere needs to be clarified by coupling more frequently to cellular/molecular measurements and behavioral testing.https://www.mdpi.com/1422-0067/22/6/3003stroke rehabilitationcerebral ischemiacognitionendurance exerciseneurotrophic factorsneurogenesis |
| spellingShingle | Nicolas Hugues Christophe Pellegrino Claudio Rivera Eric Berton Caroline Pin-Barre Jérôme Laurin Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? International Journal of Molecular Sciences stroke rehabilitation cerebral ischemia cognition endurance exercise neurotrophic factors neurogenesis |
| title | Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? |
| title_full | Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? |
| title_fullStr | Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? |
| title_full_unstemmed | Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? |
| title_short | Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? |
| title_sort | is high intensity interval training suitable to promote neuroplasticity and cognitive functions after stroke |
| topic | stroke rehabilitation cerebral ischemia cognition endurance exercise neurotrophic factors neurogenesis |
| url | https://www.mdpi.com/1422-0067/22/6/3003 |
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