Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients
Over the last decade, it has become increasingly apparent that the microbiome is a central component in human well-being and illness. However, to establish innovative therapeutic methods, it is crucial to learn more about the microbiota. Thereby, the area of metagenomics and associated bioinformatic...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-03-01
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| Series: | Bioinformatics and Biology Insights |
| Online Access: | https://doi.org/10.1177/1177932221999428 |
| _version_ | 1818556380822372352 |
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| author | Sofia Sehli Imane Allali Rajaa Chahboune Youssef Bakri Najib Al Idrissi Salsabil Hamdi Chakib Nejjari Saaïd Amzazi Hassan Ghazal |
| author_facet | Sofia Sehli Imane Allali Rajaa Chahboune Youssef Bakri Najib Al Idrissi Salsabil Hamdi Chakib Nejjari Saaïd Amzazi Hassan Ghazal |
| author_sort | Sofia Sehli |
| collection | DOAJ |
| description | Over the last decade, it has become increasingly apparent that the microbiome is a central component in human well-being and illness. However, to establish innovative therapeutic methods, it is crucial to learn more about the microbiota. Thereby, the area of metagenomics and associated bioinformatics methods and tools has become considerable in the study of the human microbiome biodiversity. The application of these metagenomics approaches to studying the gut microbiome in COVID-19 patients could be one of the promising areas of research in the fight against the SARS-CoV-2 infection and disparity. Therefore, understanding how the gut microbiome is affected by or could affect the SARS-CoV-2 is very important. Herein, we present an overview of approaches and methods used in the current published studies on COVID-19 patients and the gut microbiome. The accuracy of these researches depends on the appropriate choice and the optimal use of the metagenomics bioinformatics platforms and tools. Interestingly, most studies reported that COVID-19 patients’ microbiota are enriched with opportunistic microorganisms. The choice and use of appropriate computational tools and techniques to accurately investigate the gut microbiota is therefore critical in determining the appropriate microbiome profile for diagnosis and the most reliable antiviral or preventive microbial composition. |
| first_indexed | 2024-12-13T23:46:37Z |
| format | Article |
| id | doaj.art-71e7198b227b427e87c3b2b303f6c4fa |
| institution | Directory Open Access Journal |
| issn | 1177-9322 |
| language | English |
| last_indexed | 2024-12-13T23:46:37Z |
| publishDate | 2021-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Bioinformatics and Biology Insights |
| spelling | doaj.art-71e7198b227b427e87c3b2b303f6c4fa2022-12-21T23:26:56ZengSAGE PublishingBioinformatics and Biology Insights1177-93222021-03-011510.1177/1177932221999428Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 PatientsSofia Sehli0Imane Allali1Rajaa Chahboune2Youssef Bakri3Najib Al Idrissi4Salsabil Hamdi5Chakib Nejjari6Saaïd Amzazi7Hassan Ghazal8Department of fundamental sciences, School of Medicine, Mohammed VI University of Health Sciences, Casablanca, MoroccoLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoSchool of Medicine and Pharmacy, University Abdelmalek Essaâdi, Tangier, MoroccoLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoDepartment of Surgery, School of medicine, Mohammed VI University of Health Sciences, Casablanca, MoroccoEnvironmental Health Laboratory, Department of Research, Institut Pasteur Du Maroc, Casablanca, MoroccoDepartment of Epidemiology and Public Health, Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fez, MoroccoLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoScientific Department, National Centre for Scientific and Technical Research, Rabat, MoroccoOver the last decade, it has become increasingly apparent that the microbiome is a central component in human well-being and illness. However, to establish innovative therapeutic methods, it is crucial to learn more about the microbiota. Thereby, the area of metagenomics and associated bioinformatics methods and tools has become considerable in the study of the human microbiome biodiversity. The application of these metagenomics approaches to studying the gut microbiome in COVID-19 patients could be one of the promising areas of research in the fight against the SARS-CoV-2 infection and disparity. Therefore, understanding how the gut microbiome is affected by or could affect the SARS-CoV-2 is very important. Herein, we present an overview of approaches and methods used in the current published studies on COVID-19 patients and the gut microbiome. The accuracy of these researches depends on the appropriate choice and the optimal use of the metagenomics bioinformatics platforms and tools. Interestingly, most studies reported that COVID-19 patients’ microbiota are enriched with opportunistic microorganisms. The choice and use of appropriate computational tools and techniques to accurately investigate the gut microbiota is therefore critical in determining the appropriate microbiome profile for diagnosis and the most reliable antiviral or preventive microbial composition.https://doi.org/10.1177/1177932221999428 |
| spellingShingle | Sofia Sehli Imane Allali Rajaa Chahboune Youssef Bakri Najib Al Idrissi Salsabil Hamdi Chakib Nejjari Saaïd Amzazi Hassan Ghazal Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients Bioinformatics and Biology Insights |
| title | Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients |
| title_full | Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients |
| title_fullStr | Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients |
| title_full_unstemmed | Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients |
| title_short | Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients |
| title_sort | metagenomics approaches to investigate the gut microbiome of covid 19 patients |
| url | https://doi.org/10.1177/1177932221999428 |
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