Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis
<b>AIM:</b> To study the associations between <i>lysyl oxidase-like 1</i> (<i>LOXL1</i>) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this study, we have performed a meta-analysis to investigate the association of <i>LOXL1<...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2014-06-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067675/ |
| Summary: | <b>AIM:</b> To study the associations between <i>lysyl oxidase-like 1</i> (<i>LOXL1</i>) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this study, we have performed a meta-analysis to investigate the association of <i>LOXL1</i> polymorphisms with POAG risk.<b>METHODS:</b> Published literature from PubMed and other databases were retrieved. All studies evaluating the association between <i>LOXL1</i> polymorphisms (rs2165241, rs1048661, rs3825942) and POAG risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model.<b>RESULTS:</b> Twelve studies were identified as eligible articles, with thirteen (2098 cases and 16 473 controls), thirteen (1795 cases and 2916 controls) and sixteen population cohorts (2456 cases and 2846 controls) for the association of rs2165241, rs1048661 and rs3825942 with POAG risk respectively. Overall analyses showed no association between each <i>LOXL1</i> polymorphism and POAG risk, and the negative associations were remained when the subjects were stratified as Caucasian and Asian. The heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations (TC <i>vs</i> CC:OR, 0.79, 95%CI:0.63-0.99), and rs1048661 was associated with increased POAG risk in hospital-based populations in a dominant model (TT <i>vs</i> CC+CT:OR, 1.23, 95%CI:1.01-1.50); however, these associations were not found in population-based subjects.<b>CONCLUSION:</b> This meta-analysis suggests that <i>LOXL1 </i>polymorphisms are not associated with POAG risk. Given the limited sample size, the associations of <i>LOXL1 </i>polymorphisms with POAG risk in hospital-based populations await further investigation. |
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| ISSN: | 2222-3959 2227-4898 |