Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis
<b>AIM:</b> To study the associations between <i>lysyl oxidase-like 1</i> (<i>LOXL1</i>) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this study, we have performed a meta-analysis to investigate the association of <i>LOXL1<...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2014-06-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067675/ |
| _version_ | 1819156684410454016 |
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| author | Wen Sun Yan Sheng Yu Weng Chun-Xiao Xu Susan E.I. Williams Yu-Tao Liu Michael A. Hauser R. Rand Allingham Ming-Juan Jin Guang-Di Chen |
| author_facet | Wen Sun Yan Sheng Yu Weng Chun-Xiao Xu Susan E.I. Williams Yu-Tao Liu Michael A. Hauser R. Rand Allingham Ming-Juan Jin Guang-Di Chen |
| author_sort | Wen Sun |
| collection | DOAJ |
| description | <b>AIM:</b> To study the associations between <i>lysyl oxidase-like 1</i> (<i>LOXL1</i>) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this study, we have performed a meta-analysis to investigate the association of <i>LOXL1</i> polymorphisms with POAG risk.<b>METHODS:</b> Published literature from PubMed and other databases were retrieved. All studies evaluating the association between <i>LOXL1</i> polymorphisms (rs2165241, rs1048661, rs3825942) and POAG risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model.<b>RESULTS:</b> Twelve studies were identified as eligible articles, with thirteen (2098 cases and 16 473 controls), thirteen (1795 cases and 2916 controls) and sixteen population cohorts (2456 cases and 2846 controls) for the association of rs2165241, rs1048661 and rs3825942 with POAG risk respectively. Overall analyses showed no association between each <i>LOXL1</i> polymorphism and POAG risk, and the negative associations were remained when the subjects were stratified as Caucasian and Asian. The heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations (TC <i>vs</i> CC:OR, 0.79, 95%CI:0.63-0.99), and rs1048661 was associated with increased POAG risk in hospital-based populations in a dominant model (TT <i>vs</i> CC+CT:OR, 1.23, 95%CI:1.01-1.50); however, these associations were not found in population-based subjects.<b>CONCLUSION:</b> This meta-analysis suggests that <i>LOXL1 </i>polymorphisms are not associated with POAG risk. Given the limited sample size, the associations of <i>LOXL1 </i>polymorphisms with POAG risk in hospital-based populations await further investigation. |
| first_indexed | 2024-12-22T15:56:47Z |
| format | Article |
| id | doaj.art-71e71fe3345e4f619863ae662aee7bb4 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-22T15:56:47Z |
| publishDate | 2014-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-71e71fe3345e4f619863ae662aee7bb42022-12-21T18:20:46ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982014-06-017355055610.3980/j.issn.2222-3959.2014.03.29Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysisWen Sun0Yan Sheng1Yu Weng2Chun-Xiao Xu3Susan E.I. Williams4Yu-Tao Liu5Michael A. Hauser6R. Rand Allingham7Ming-Juan Jin8Guang-Di Chen9Department of Ophthalmology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China<br>Department of Ophthalmology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China<br>Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China<br>Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China<br>Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg 2050, South Africa<br>Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA<br>Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA<br>;Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina 27710, USACenter for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA<br>;Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina 27710, USADepartment of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China<br>Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China<br><b>AIM:</b> To study the associations between <i>lysyl oxidase-like 1</i> (<i>LOXL1</i>) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this study, we have performed a meta-analysis to investigate the association of <i>LOXL1</i> polymorphisms with POAG risk.<b>METHODS:</b> Published literature from PubMed and other databases were retrieved. All studies evaluating the association between <i>LOXL1</i> polymorphisms (rs2165241, rs1048661, rs3825942) and POAG risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model.<b>RESULTS:</b> Twelve studies were identified as eligible articles, with thirteen (2098 cases and 16 473 controls), thirteen (1795 cases and 2916 controls) and sixteen population cohorts (2456 cases and 2846 controls) for the association of rs2165241, rs1048661 and rs3825942 with POAG risk respectively. Overall analyses showed no association between each <i>LOXL1</i> polymorphism and POAG risk, and the negative associations were remained when the subjects were stratified as Caucasian and Asian. The heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations (TC <i>vs</i> CC:OR, 0.79, 95%CI:0.63-0.99), and rs1048661 was associated with increased POAG risk in hospital-based populations in a dominant model (TT <i>vs</i> CC+CT:OR, 1.23, 95%CI:1.01-1.50); however, these associations were not found in population-based subjects.<b>CONCLUSION:</b> This meta-analysis suggests that <i>LOXL1 </i>polymorphisms are not associated with POAG risk. Given the limited sample size, the associations of <i>LOXL1 </i>polymorphisms with POAG risk in hospital-based populations await further investigation.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067675/glaucomagene polymorphismmeta-analysislysyl oxidase-like 1lysyl oxidase-like 1 |
| spellingShingle | Wen Sun Yan Sheng Yu Weng Chun-Xiao Xu Susan E.I. Williams Yu-Tao Liu Michael A. Hauser R. Rand Allingham Ming-Juan Jin Guang-Di Chen Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis International Journal of Ophthalmology glaucoma gene polymorphism meta-analysis lysyl oxidase-like 1 lysyl oxidase-like 1 |
| title | Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis |
| title_full | Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis |
| title_fullStr | Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis |
| title_full_unstemmed | Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis |
| title_short | Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis |
| title_sort | lack of association between lysyl oxidase like 1 polymorphisms and primary open angle glaucoma a meta analysis |
| topic | glaucoma gene polymorphism meta-analysis lysyl oxidase-like 1 lysyl oxidase-like 1 |
| url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067675/ |
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