Review: Bioengineering approach for the repair and regeneration of peripheral nerve
Complex craniofacial surgeries of damaged tissues have several limitations, which present complications and challenges when trying to replicate facial function and structure. Traditional treatment techniques have shown suitable nerve function regeneration with various drawbacks. As technology contin...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2019-12-01
|
| Series: | Bioactive Materials |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X18300458 |
| _version_ | 1797203236793352192 |
|---|---|
| author | Joshua Moskow Bryan Ferrigno Nikhil Mistry Devina Jaiswal Ketan Bulsara Swetha Rudraiah Sangamesh G. Kumbar |
| author_facet | Joshua Moskow Bryan Ferrigno Nikhil Mistry Devina Jaiswal Ketan Bulsara Swetha Rudraiah Sangamesh G. Kumbar |
| author_sort | Joshua Moskow |
| collection | DOAJ |
| description | Complex craniofacial surgeries of damaged tissues have several limitations, which present complications and challenges when trying to replicate facial function and structure. Traditional treatment techniques have shown suitable nerve function regeneration with various drawbacks. As technology continues to advance, new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and structure. This article will summarize recent bioengineering strategies involving biodegradable composite scaffolds, bioactive factors, and external stimuli alone or in combination to support peripheral nerve regeneration. Particular emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process. Keywords: Peripheral nerve regeneration, Composite materials, Growth factor, Electrical stimulation |
| first_indexed | 2024-04-24T08:16:08Z |
| format | Article |
| id | doaj.art-71e81e0f0d97456bb5c773fed16e51c1 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:16:08Z |
| publishDate | 2019-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-71e81e0f0d97456bb5c773fed16e51c12024-04-17T03:51:28ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2019-12-014107113Review: Bioengineering approach for the repair and regeneration of peripheral nerveJoshua Moskow0Bryan Ferrigno1Nikhil Mistry2Devina Jaiswal3Ketan Bulsara4Swetha Rudraiah5Sangamesh G. Kumbar6Department of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA; Department of Biomedical Engineering, University of Connecticut, 260Glenbrook Road, Unit 3247, Storrs, CT 06269, USADepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USADepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USADepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA; Department of Biomedical Engineering, University of Connecticut, 260Glenbrook Road, Unit 3247, Storrs, CT 06269, USADepartment of Surgery, University of Connecticut Health, 263 Farmington Ave., Farmington, CT 06030, USADepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Saint Joseph, 229 Trumbull St., Hartford CT 06103, USADepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA; Department of Biomedical Engineering, University of Connecticut, 260Glenbrook Road, Unit 3247, Storrs, CT 06269, USA; Corresponding author. Department of Orthopaedic Surgery, Department of Biomedical Engineering, Department of Materials Science and Engineering, The University of Connecticut, Farmington, CT 06030-1320, USA.Complex craniofacial surgeries of damaged tissues have several limitations, which present complications and challenges when trying to replicate facial function and structure. Traditional treatment techniques have shown suitable nerve function regeneration with various drawbacks. As technology continues to advance, new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and structure. This article will summarize recent bioengineering strategies involving biodegradable composite scaffolds, bioactive factors, and external stimuli alone or in combination to support peripheral nerve regeneration. Particular emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process. Keywords: Peripheral nerve regeneration, Composite materials, Growth factor, Electrical stimulationhttp://www.sciencedirect.com/science/article/pii/S2452199X18300458 |
| spellingShingle | Joshua Moskow Bryan Ferrigno Nikhil Mistry Devina Jaiswal Ketan Bulsara Swetha Rudraiah Sangamesh G. Kumbar Review: Bioengineering approach for the repair and regeneration of peripheral nerve Bioactive Materials |
| title | Review: Bioengineering approach for the repair and regeneration of peripheral nerve |
| title_full | Review: Bioengineering approach for the repair and regeneration of peripheral nerve |
| title_fullStr | Review: Bioengineering approach for the repair and regeneration of peripheral nerve |
| title_full_unstemmed | Review: Bioengineering approach for the repair and regeneration of peripheral nerve |
| title_short | Review: Bioengineering approach for the repair and regeneration of peripheral nerve |
| title_sort | review bioengineering approach for the repair and regeneration of peripheral nerve |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X18300458 |
| work_keys_str_mv | AT joshuamoskow reviewbioengineeringapproachfortherepairandregenerationofperipheralnerve AT bryanferrigno reviewbioengineeringapproachfortherepairandregenerationofperipheralnerve AT nikhilmistry reviewbioengineeringapproachfortherepairandregenerationofperipheralnerve AT devinajaiswal reviewbioengineeringapproachfortherepairandregenerationofperipheralnerve AT ketanbulsara reviewbioengineeringapproachfortherepairandregenerationofperipheralnerve AT swetharudraiah reviewbioengineeringapproachfortherepairandregenerationofperipheralnerve AT sangameshgkumbar reviewbioengineeringapproachfortherepairandregenerationofperipheralnerve |