HB UBE-2 variant hemoglobin case detected during HBA1C measurement
Hemoglobin A1c is used in the diagnosis and the management of Diabetes Mellitus. The accuracy of hemoglobin A1c measurements may be affected by various factors and the most common interferences are variant hemoglobins. During hemoglobin A1c measurement of a 56-year-old female patient with Type 2 Dia...
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| Format: | Article |
| Language: | English |
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Cukurova University
2021-06-01
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| Series: | Cukurova Medical Journal |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1522381 |
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| author | Evin Kocatürk Zeynep Kusku Kiraz Şükrü Demir Hava Üsküdar Teke İ. Özkan Alataş Oğuz Çilingir |
| author_facet | Evin Kocatürk Zeynep Kusku Kiraz Şükrü Demir Hava Üsküdar Teke İ. Özkan Alataş Oğuz Çilingir |
| author_sort | Evin Kocatürk |
| collection | DOAJ |
| description | Hemoglobin A1c is used in the diagnosis and the management of Diabetes Mellitus. The accuracy of hemoglobin A1c measurements may be affected by various factors and the most common interferences are variant hemoglobins. During hemoglobin A1c measurement of a 56-year-old female patient with Type 2 Diabetes Mellitus, an abnormal peak was detected in the chromatogram by high performance liquid chromatography and an inconsistency was determined between the serum glucose and the hemoglobin A1c value. Patient’s hemoglobin A, hemoglobin A2, hemoglobin F and variant hemoglobin were detected as 73.3, 2, 0.3 and 24.4% respectively in the capillary electrophoresis. Hemoglobin value of patient was 13.5 g / dL, red blood cell 4.40x106 / µL, mean cell volume 89.8 fL, mean corpuscular hemoglobin 30.7 pg and the blood smear examination was evaluated as normal, however, heterozygote (αube-2α/αα) NM_000558.4 c.205A>G p.(Asn69Asp) variation was detected in hemoglobin A1 gene by whole exome sequencing and this variation is defined as hemoglobin Ube-2. It should be known that variant hemoglobin may affect to hemoglobin A1c measurements and especially when the results are incompatible with patient’s clinical status, this effect should be considered. |
| first_indexed | 2024-04-10T11:39:37Z |
| format | Article |
| id | doaj.art-71eabb421d504b7a92408e2671e6864a |
| institution | Directory Open Access Journal |
| issn | 2602-3040 |
| language | English |
| last_indexed | 2024-04-10T11:39:37Z |
| publishDate | 2021-06-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Cukurova Medical Journal |
| spelling | doaj.art-71eabb421d504b7a92408e2671e6864a2023-02-15T16:17:36ZengCukurova UniversityCukurova Medical Journal2602-30402021-06-0146286686848HB UBE-2 variant hemoglobin case detected during HBA1C measurementEvin Kocatürk0Zeynep Kusku Kiraz1Şükrü Demir2Hava Üsküdar Teke3İ. Özkan Alataş4Oğuz Çilingir5ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİHemoglobin A1c is used in the diagnosis and the management of Diabetes Mellitus. The accuracy of hemoglobin A1c measurements may be affected by various factors and the most common interferences are variant hemoglobins. During hemoglobin A1c measurement of a 56-year-old female patient with Type 2 Diabetes Mellitus, an abnormal peak was detected in the chromatogram by high performance liquid chromatography and an inconsistency was determined between the serum glucose and the hemoglobin A1c value. Patient’s hemoglobin A, hemoglobin A2, hemoglobin F and variant hemoglobin were detected as 73.3, 2, 0.3 and 24.4% respectively in the capillary electrophoresis. Hemoglobin value of patient was 13.5 g / dL, red blood cell 4.40x106 / µL, mean cell volume 89.8 fL, mean corpuscular hemoglobin 30.7 pg and the blood smear examination was evaluated as normal, however, heterozygote (αube-2α/αα) NM_000558.4 c.205A>G p.(Asn69Asp) variation was detected in hemoglobin A1 gene by whole exome sequencing and this variation is defined as hemoglobin Ube-2. It should be known that variant hemoglobin may affect to hemoglobin A1c measurements and especially when the results are incompatible with patient’s clinical status, this effect should be considered.https://dergipark.org.tr/tr/download/article-file/1522381hemoglobin a1cvariant hemoglobinhemoglobin ube-2interferencehemoglobin a1cvaryant hemoglobinhemoglobin ube-2i̇nterferans |
| spellingShingle | Evin Kocatürk Zeynep Kusku Kiraz Şükrü Demir Hava Üsküdar Teke İ. Özkan Alataş Oğuz Çilingir HB UBE-2 variant hemoglobin case detected during HBA1C measurement Cukurova Medical Journal hemoglobin a1c variant hemoglobin hemoglobin ube-2 interference hemoglobin a1c varyant hemoglobin hemoglobin ube-2 i̇nterferans |
| title | HB UBE-2 variant hemoglobin case detected during HBA1C measurement |
| title_full | HB UBE-2 variant hemoglobin case detected during HBA1C measurement |
| title_fullStr | HB UBE-2 variant hemoglobin case detected during HBA1C measurement |
| title_full_unstemmed | HB UBE-2 variant hemoglobin case detected during HBA1C measurement |
| title_short | HB UBE-2 variant hemoglobin case detected during HBA1C measurement |
| title_sort | hb ube 2 variant hemoglobin case detected during hba1c measurement |
| topic | hemoglobin a1c variant hemoglobin hemoglobin ube-2 interference hemoglobin a1c varyant hemoglobin hemoglobin ube-2 i̇nterferans |
| url | https://dergipark.org.tr/tr/download/article-file/1522381 |
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