Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound

Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound

The purpose of this study was to investigate whether doxorubicin nanobubbles (DOX-NB) combined with diagnostic ultrasound (DUS) irradiation could downregulate the expression of carbonic anhydrase IX (CAIX) in mouse xenograft nasopharyngeal carcinoma (NPC) model. In this study, the prepared DOX-NB wa...

Full description

Bibliographic Details
Main Authors:	Li Rong, Lu Liugui, Huang Zhaoxi, Gao Yong
Format:	Article
Language:	English
Published:	De Gruyter 2024-02-01
Series:	Open Medicine
Subjects:	diagnostic ultrasound nasopharyngeal carcinoma carbonic anhydrase ix doxorubicin nanobubbles microvascular density
Online Access:	https://doi.org/10.1515/med-2024-0910

Similar Items

Indocyanine Green-Loaded Nanobubbles Targeting Carbonic Anhydrase IX for Multimodal Imaging of Renal Cell Carcinoma
by: Zhong C, et al.
Published: (2023-05-01)

Construction of ultrasonic nanobubbles carrying CAIX polypeptides to target carcinoma cells derived from various organs
by: Lianhua Zhu, et al.
Published: (2017-09-01)

Expression and prognostic value of carbonic anhydrase IX (CA-IX) in bladder urothelial carcinoma
by: An-Ping Xiang, et al.
Published: (2022-08-01)

Primary Duodenal Adenocarcinoma Expressing Carbonic Anhydrase IX
by: Kimitoshi Kubo, et al.
Published: (2022-05-01)

Targeting Carbonic Anhydrase IX Activity and Expression
by: Brian P. Mahon, et al.
Published: (2015-01-01)

An update on anticancer drug development and delivery targeting carbonic anhydrase IX
by: Justina Kazokaitė, et al.
Published: (2017-11-01)

Molecular Modeling, Synthesis, and preliminary pharmacological evaluation of New Sulfonamide Derivatives as Selective Carbonic Anhydrase XII and IX inhibitors (Research)
by: Samer Tareq Jasim, et al.
Published: (2024-04-01)

Carbonic Anhydrase-IX Guided Albumin Nanoparticles for Hypoxia-mediated Triple-Negative Breast Cancer Cell Killing and Imaging of Patient-derived Tumor
by: Katyayani Tatiparti, et al.
Published: (2020-05-01)

Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII
by: Ashraf K. El-Damasy, et al.
Published: (2023-12-01)

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity
by: Mariantonia Logozzi, et al.
Published: (2019-01-01)

Co-vulnerabilities of inhibiting carbonic anhydrase IX in ferroptosis-mediated tumor cell death
by: Paul C. McDonald, et al.
Published: (2023-11-01)

The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX
by: Zainab Saad Yusuf, et al.
Published: (2022-12-01)

Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors
by: Lamya H. Al-Wahaibi, et al.
Published: (2021-08-01)

SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration
by: Katja Eloranta, et al.
Published: (2023-01-01)

Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line
by: Ismail Koyuncu, et al.
Published: (2019-01-01)

Aza-BODIPY based carbonic anhydrase IX: Strategy to overcome hypoxia limitation in photodynamic therapy
by: Thitima Pewklang, et al.
Published: (2022-11-01)

Design, synthesis and evaluation of 18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging
by: Zhengxing Zhang, et al.
Published: (2017-01-01)

Carbonic anhydrase IX-related tumoral hypoxia predicts worse prognosis in breast cancer: A systematic review and meta-analysis
by: Warapan Numprasit, et al.
Published: (2023-03-01)

Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment
by: Geetha Venkateswaran, et al.
Published: (2020-11-01)

New Monoclonal Antibodies for a Selective Detection of Membrane-Associated and Soluble Forms of Carbonic Anhydrase IX in Human Cell Lines and Biological Samples
by: Dovile Stravinskiene, et al.
Published: (2019-07-01)

Biocompatible Chitosan Nanobubbles for Ultrasound-Mediated Targeted Delivery of Doxorubicin
by: Xiaoying Zhou, et al.
Published: (2019-01-01)

Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer
by: Chong Hui Clara Ong, et al.
Published: (2022-06-01)

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX
by: Anne E.G. Lenferink, et al.
Published: (2021-01-01)

Design, Synthesis and Biological Evaluation of New Carbohydrate-Based Coumarin Derivatives as Selective Carbonic Anhydrase IX Inhibitors via “Click” Reaction
by: Naying Chu, et al.
Published: (2022-08-01)

Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX
by: Aivaras Vaškevičius, et al.
Published: (2024-12-01)

Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells
by: Ismail Koyuncu, et al.
Published: (2018-01-01)

Identification of Carbonic Anhydrase IX as a Novel Target for Endoscopic Molecular Imaging of Human Bladder Cancer
by: Jiaqi Wang, et al.
Published: (2018-06-01)

Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats
by: Sara Amiranda, et al.
Published: (2025-02-01)

New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors
by: Jacob Combs, et al.
Published: (2023-01-01)

2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms
by: Lisa Sequeira, et al.
Published: (2023-12-01)

Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy
by: Özgen Arslan Solmaz, et al.
Published: (2025-01-01)

From Initial Hit to Crystal Optimization with Microseeding of Human Carbonic Anhydrase IX—A Case Study for Neutron Protein Crystallography
by: Katarina Koruza, et al.
Published: (2018-11-01)

Nanobubbles: an emerging science in nanotechnology
by: Gita Chaurasia
Published: (2023-01-01)

Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion
by: Annachiara Sarnella, et al.
Published: (2022-04-01)

Dual-Functional Liposomes with Carbonic Anhydrase IX Antibody and BR2 Peptide Modification Effectively Improve Intracellular Delivery of Cantharidin to Treat Orthotopic Hepatocellular Carcinoma Mice
by: Xue Zhang, et al.
Published: (2019-09-01)

Synthesis and Biological Evaluation of Coumarin-Linked 4-Anilinomethyl-1,2,3-Triazoles as Potent Inhibitors of Carbonic Anhydrases IX and XIII Involved in Tumorigenesis
by: Pavitra S. Thacker, et al.
Published: (2021-04-01)

Carbonic anhydrase IX inhibitor S4 triggers release of DAMPs related to immunogenic cell death in glioma cells via endoplasmic reticulum stress pathway
by: Jing Cui, et al.
Published: (2023-06-01)

Surface Nanobubbles Are Stabilized by Hydrophobic Attraction
by: Tan, Beng Hau, et al.
Published: (2018)

Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors
by: Baijayantimala Swain, et al.
Published: (2019-01-01)

Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors
by: Toni C. Denner, et al.
Published: (2023-11-01)