Alcohol-Specific Mortality in People With Epilepsy: Cohort Studies in Two Independent Population-Based Datasets
Objectives: The risk of dying by alcohol-specific causes in people with epilepsy has seldom been reported from population-based studies. We aimed to estimate the relative risk of alcohol-specific mortality in people with epilepsy, and the extent to which problematic alcohol use was previously identi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.623139/full |
| _version_ | 1818418026894065664 |
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| author | Hayley C. Gorton Roger T. Webb Roger T. Webb Rosa Parisi Matthew J. Carr Matthew J. Carr Marcos DelPozo-Banos Kieran J. Moriarty W. Owen Pickrell W. Owen Pickrell Ann John Darren M. Ashcroft Darren M. Ashcroft |
| author_facet | Hayley C. Gorton Roger T. Webb Roger T. Webb Rosa Parisi Matthew J. Carr Matthew J. Carr Marcos DelPozo-Banos Kieran J. Moriarty W. Owen Pickrell W. Owen Pickrell Ann John Darren M. Ashcroft Darren M. Ashcroft |
| author_sort | Hayley C. Gorton |
| collection | DOAJ |
| description | Objectives: The risk of dying by alcohol-specific causes in people with epilepsy has seldom been reported from population-based studies. We aimed to estimate the relative risk of alcohol-specific mortality in people with epilepsy, and the extent to which problematic alcohol use was previously identified in the patients' medical records.Method: We delineated cohort studies in two population-based datasets, the Clinical Practice Research Datalink (CPRD GOLD) in England (January 01, 2001–December 31, 2014) and the Secure Anonymised Information Linkage (SAIL) Databank in Wales (January 01, 2001–December 31, 2014), linked to hospitalization and mortality records. People with epilepsy were matched to up to 20 persons without epilepsy on gender, age (±2 years) and registered general practice. We identified alcohol-specific death from Office for National Statistics (ONS) records using specified ICD-10 codes. We further identified prescriptions, interventions and hospitalisations related to alcohol use.Results: In the CPRD GOLD, we identified 9,871 individuals in the incident epilepsy cohort and 185,800 in the comparison cohort and, in the SAIL Databank, these numbers were 5,569 and 110,021, respectively. We identified a five-fold increased risk of alcohol-specific mortality in people with epilepsy vs. those without the condition in our pooled estimate across the two datasets (deprivation-adjusted HR 4.85, 95%CI 3.46–6.79).Conclusions: People with epilepsy are at increased risk of dying by an alcohol-specific cause than those without the disorder. It is plausible that serious alcohol misuse could either contribute to the development of epilepsy or it could commence subsequent to epilepsy being diagnosed. Regardless of the direction of the association, it is important that the risk of dying as a consequence of alcohol misuse is accurately quantified in people affected by epilepsy. Systematically-applied, sensitive assessment of alcohol consumption by healthcare professionals, at opportunistic, clinical contacts, with rapid access to quality treatment services, should be mandatory and play a key role in reduction of health harms and mortality. |
| first_indexed | 2024-12-14T12:16:08Z |
| format | Article |
| id | doaj.art-71eba17568484b2e867e52c9d03e19ea |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T12:16:08Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-71eba17568484b2e867e52c9d03e19ea2022-12-21T23:01:38ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-01-011110.3389/fneur.2020.623139623139Alcohol-Specific Mortality in People With Epilepsy: Cohort Studies in Two Independent Population-Based DatasetsHayley C. Gorton0Roger T. Webb1Roger T. Webb2Rosa Parisi3Matthew J. Carr4Matthew J. Carr5Marcos DelPozo-Banos6Kieran J. Moriarty7W. Owen Pickrell8W. Owen Pickrell9Ann John10Darren M. Ashcroft11Darren M. Ashcroft12School of Applied Sciences, University of Huddersfield, Huddersfield, United KingdomNIHR Greater Manchester Patient Safety Translational Research Centre, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, United KingdomDivision of Psychology & Mental Health, Centre for Mental Health and Safety, Manchester Academic Health Sciences Centre (MAHSC), Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester, United KingdomDivision of Informatics, Imaging & Data Sciences, Manchester Academic Health Sciences Centre (MAHSC), Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester, United KingdomNIHR Greater Manchester Patient Safety Translational Research Centre, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, United KingdomCentre for Pharmacoepidemiology and Drug Safety, Manchester Academic Health Sciences Centre (MAHSC), Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester, United KingdomFarr Institute, Swansea University Medical School, Swansea, United KingdomBolton NHS Foundation Trust, Bolton, United KingdomNeurology and Molecular Neuroscience Research Group, Swansea University Medical School, Swansea University, Swansea, United KingdomNeurology Department, Morriston Hospital, Swansea Bay University Health Board, Swansea, United KingdomFarr Institute, Swansea University Medical School, Swansea, United KingdomNIHR Greater Manchester Patient Safety Translational Research Centre, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, United KingdomCentre for Pharmacoepidemiology and Drug Safety, Manchester Academic Health Sciences Centre (MAHSC), Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester, United KingdomObjectives: The risk of dying by alcohol-specific causes in people with epilepsy has seldom been reported from population-based studies. We aimed to estimate the relative risk of alcohol-specific mortality in people with epilepsy, and the extent to which problematic alcohol use was previously identified in the patients' medical records.Method: We delineated cohort studies in two population-based datasets, the Clinical Practice Research Datalink (CPRD GOLD) in England (January 01, 2001–December 31, 2014) and the Secure Anonymised Information Linkage (SAIL) Databank in Wales (January 01, 2001–December 31, 2014), linked to hospitalization and mortality records. People with epilepsy were matched to up to 20 persons without epilepsy on gender, age (±2 years) and registered general practice. We identified alcohol-specific death from Office for National Statistics (ONS) records using specified ICD-10 codes. We further identified prescriptions, interventions and hospitalisations related to alcohol use.Results: In the CPRD GOLD, we identified 9,871 individuals in the incident epilepsy cohort and 185,800 in the comparison cohort and, in the SAIL Databank, these numbers were 5,569 and 110,021, respectively. We identified a five-fold increased risk of alcohol-specific mortality in people with epilepsy vs. those without the condition in our pooled estimate across the two datasets (deprivation-adjusted HR 4.85, 95%CI 3.46–6.79).Conclusions: People with epilepsy are at increased risk of dying by an alcohol-specific cause than those without the disorder. It is plausible that serious alcohol misuse could either contribute to the development of epilepsy or it could commence subsequent to epilepsy being diagnosed. Regardless of the direction of the association, it is important that the risk of dying as a consequence of alcohol misuse is accurately quantified in people affected by epilepsy. Systematically-applied, sensitive assessment of alcohol consumption by healthcare professionals, at opportunistic, clinical contacts, with rapid access to quality treatment services, should be mandatory and play a key role in reduction of health harms and mortality.https://www.frontiersin.org/articles/10.3389/fneur.2020.623139/fullepilepsyalcoholalcohol-specificcohortobservational |
| spellingShingle | Hayley C. Gorton Roger T. Webb Roger T. Webb Rosa Parisi Matthew J. Carr Matthew J. Carr Marcos DelPozo-Banos Kieran J. Moriarty W. Owen Pickrell W. Owen Pickrell Ann John Darren M. Ashcroft Darren M. Ashcroft Alcohol-Specific Mortality in People With Epilepsy: Cohort Studies in Two Independent Population-Based Datasets Frontiers in Neurology epilepsy alcohol alcohol-specific cohort observational |
| title | Alcohol-Specific Mortality in People With Epilepsy: Cohort Studies in Two Independent Population-Based Datasets |
| title_full | Alcohol-Specific Mortality in People With Epilepsy: Cohort Studies in Two Independent Population-Based Datasets |
| title_fullStr | Alcohol-Specific Mortality in People With Epilepsy: Cohort Studies in Two Independent Population-Based Datasets |
| title_full_unstemmed | Alcohol-Specific Mortality in People With Epilepsy: Cohort Studies in Two Independent Population-Based Datasets |
| title_short | Alcohol-Specific Mortality in People With Epilepsy: Cohort Studies in Two Independent Population-Based Datasets |
| title_sort | alcohol specific mortality in people with epilepsy cohort studies in two independent population based datasets |
| topic | epilepsy alcohol alcohol-specific cohort observational |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.623139/full |
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