Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction
A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light on pathophysiological mechanisms. Cancer is now considered a heterogeneous ecosystem, formed by tumor cells and the micro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/5/264 |
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| author | Ezequiel Monferrer Isaac Vieco-Martí Amparo López-Carrasco Fernando Fariñas Sergio Abanades Luis de la Cruz-Merino Rosa Noguera Tomás Álvaro Naranjo |
| author_facet | Ezequiel Monferrer Isaac Vieco-Martí Amparo López-Carrasco Fernando Fariñas Sergio Abanades Luis de la Cruz-Merino Rosa Noguera Tomás Álvaro Naranjo |
| author_sort | Ezequiel Monferrer |
| collection | DOAJ |
| description | A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light on pathophysiological mechanisms. Cancer is now considered a heterogeneous ecosystem, formed by tumor cells and the microenvironment, which is molecularly, phenotypically, and metabolically reprogrammable. A wealth of evidence confirms metabolic reprogramming activity as the minimum common denominator of cancer, grouping together a wide variety of aberrations that can affect any of the different metabolic pathways involved in cell physiology. This forms the basis for a new proposed classification of cancer according to the altered metabolic pathway(s) and degree of energy dysfunction. Enhanced understanding of the metabolic reprogramming pathways of fatty acids, amino acids, carbohydrates, hypoxia, and acidosis can bring about new therapeutic intervention possibilities from a metabolic perspective of cancer. |
| first_indexed | 2024-03-10T12:02:51Z |
| format | Article |
| id | doaj.art-71ebd087b3b54a598c8c467cc4834ced |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T12:02:51Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-71ebd087b3b54a598c8c467cc4834ced2023-11-21T16:49:36ZengMDPI AGMetabolites2218-19892021-04-0111526410.3390/metabo11050264Metabolic Classification and Intervention Opportunities for Tumor Energy DysfunctionEzequiel Monferrer0Isaac Vieco-Martí1Amparo López-Carrasco2Fernando Fariñas3Sergio Abanades4Luis de la Cruz-Merino5Rosa Noguera6Tomás Álvaro Naranjo7Department of Pathology, Medical School, INCLIVA Biomedical Health Research Institute, University of Valencia, 46010 Valencia, SpainDepartment of Pathology, Medical School, INCLIVA Biomedical Health Research Institute, University of Valencia, 46010 Valencia, SpainDepartment of Pathology, Medical School, INCLIVA Biomedical Health Research Institute, University of Valencia, 46010 Valencia, SpainYnmun Group, Institute of Clinical Immunology and Infectious Diseases, 29004 Málaga, SpainIntegrative and Conscious Health Institute, 08008 Barcelona, SpainClinical Oncology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, SpainDepartment of Pathology, Medical School, INCLIVA Biomedical Health Research Institute, University of Valencia, 46010 Valencia, SpainLow Prevalence Tumors, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, SpainA comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light on pathophysiological mechanisms. Cancer is now considered a heterogeneous ecosystem, formed by tumor cells and the microenvironment, which is molecularly, phenotypically, and metabolically reprogrammable. A wealth of evidence confirms metabolic reprogramming activity as the minimum common denominator of cancer, grouping together a wide variety of aberrations that can affect any of the different metabolic pathways involved in cell physiology. This forms the basis for a new proposed classification of cancer according to the altered metabolic pathway(s) and degree of energy dysfunction. Enhanced understanding of the metabolic reprogramming pathways of fatty acids, amino acids, carbohydrates, hypoxia, and acidosis can bring about new therapeutic intervention possibilities from a metabolic perspective of cancer.https://www.mdpi.com/2218-1989/11/5/264tumor ecosystemtumor reprogrammingtumor microenvironment |
| spellingShingle | Ezequiel Monferrer Isaac Vieco-Martí Amparo López-Carrasco Fernando Fariñas Sergio Abanades Luis de la Cruz-Merino Rosa Noguera Tomás Álvaro Naranjo Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction Metabolites tumor ecosystem tumor reprogramming tumor microenvironment |
| title | Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction |
| title_full | Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction |
| title_fullStr | Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction |
| title_full_unstemmed | Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction |
| title_short | Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction |
| title_sort | metabolic classification and intervention opportunities for tumor energy dysfunction |
| topic | tumor ecosystem tumor reprogramming tumor microenvironment |
| url | https://www.mdpi.com/2218-1989/11/5/264 |
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