Effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbits
This article presents the results of physiological and biochemical investigations of the copper nanoparticles effect on the organism of mature female rabbits. Clinical observations and biochemical parameters of blood would permit to assess the safety of use of obtained nanoparticles and to evaluate...
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| Format: | Article |
| Language: | English |
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Institute of Animal Biology NAAS
2020-05-01
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| Series: | Біологія тварин |
| Subjects: | |
| Online Access: | http://aminbiol.com.ua/index.php/archive/126-archive/bt-22-1-2020/1112-effects-of-copper-nanoparticles-on-the-biochemical-parameters-of-blood-serum-of-female-rabbits |
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| author | Yu. I. Slyvchuk O. V. Shtapenko I. I. Hevkan V. Y. Syrvatka O. Yu. Slyvchuk |
| author_facet | Yu. I. Slyvchuk O. V. Shtapenko I. I. Hevkan V. Y. Syrvatka O. Yu. Slyvchuk |
| author_sort | Yu. I. Slyvchuk |
| collection | DOAJ |
| description | This article presents the results of physiological and biochemical investigations of the copper nanoparticles effect on the organism of mature female rabbits. Clinical observations and biochemical parameters of blood would permit to assess the safety of use of obtained nanoparticles and to evaluate the influence of prolonged intraperitoneal administration thereof on the metabolism of the animals, as well as, basing on further studies, to develop drugs for the treatment of various pathologies of the reproductive system of farm animals. For this investigation 18 four-month-old female rabbits of the Blanc de Termonde breed weighing 3–3.5 kg and analogous by biochemical parameters of blood serum were selected. They were divided into three groups: control, 1st and 2nd experimental ones, each group containing 6 rabbits. Every 7th day of the 28-day period the rabbits were subjected to intraperitoneal administration of drugs. The rabbits of the control group received 0.9% physiological solution as placebo, 1.5 ml/kg per injection. The rabbits of the experimental group received a preparation containing copper nanoparticles. The investigation results showed a positive influence of the studied copper nanoparticles on the metabolic processes. Intraperitoneal administration of copper nanoparticles on initial stages of the study (after the second injection) produced increased ALT and AST activities, which might be associated with the adaptation of organism to the introduced drugs. The decreased LDH activity in the blood serum of the rabbits during the administration of the preparations might be associated with enhanced intracellular metabolic processes requiring considerable expenditures of energy. The dynamics of the gamma glutamate transferase activity remained on the same level in the control and both experimental groups of female rabbits, indicating that the introduced copper nanoparticles drugs were not toxic. The administration of copper nanoparticles in the dose of 50 μg/kg of body weight has positive effects on the reproductive system of female rabbits and the processes of embryonic development. |
| first_indexed | 2024-04-13T05:13:46Z |
| format | Article |
| id | doaj.art-71ecb6dee7574a9fb38ae5ddcf221063 |
| institution | Directory Open Access Journal |
| issn | 1681-0015 2313-2191 |
| language | English |
| last_indexed | 2024-04-13T05:13:46Z |
| publishDate | 2020-05-01 |
| publisher | Institute of Animal Biology NAAS |
| record_format | Article |
| series | Біологія тварин |
| spelling | doaj.art-71ecb6dee7574a9fb38ae5ddcf2210632022-12-22T03:00:57ZengInstitute of Animal Biology NAASБіологія тварин1681-00152313-21912020-05-01221202510.15407/animbiol22.01.020Effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbitsYu. I. Slyvchuk0O. V. Shtapenko1https://orcid.org/0000-0002-1192-8432I. I. Hevkan2V. Y. Syrvatka3https://orcid.org/0000-0003-1326-6206O. Yu. Slyvchuk4https://orcid.org/0000-0002-0229-5848Institute of Animal Biology NAASInstitute of Animal Biology NAASInstitute of Animal Biology NAASIvan Franko National University of LvivState Scientific-Research Control Institute of Veterinary Medicinal Products and Feed AdditivesThis article presents the results of physiological and biochemical investigations of the copper nanoparticles effect on the organism of mature female rabbits. Clinical observations and biochemical parameters of blood would permit to assess the safety of use of obtained nanoparticles and to evaluate the influence of prolonged intraperitoneal administration thereof on the metabolism of the animals, as well as, basing on further studies, to develop drugs for the treatment of various pathologies of the reproductive system of farm animals. For this investigation 18 four-month-old female rabbits of the Blanc de Termonde breed weighing 3–3.5 kg and analogous by biochemical parameters of blood serum were selected. They were divided into three groups: control, 1st and 2nd experimental ones, each group containing 6 rabbits. Every 7th day of the 28-day period the rabbits were subjected to intraperitoneal administration of drugs. The rabbits of the control group received 0.9% physiological solution as placebo, 1.5 ml/kg per injection. The rabbits of the experimental group received a preparation containing copper nanoparticles. The investigation results showed a positive influence of the studied copper nanoparticles on the metabolic processes. Intraperitoneal administration of copper nanoparticles on initial stages of the study (after the second injection) produced increased ALT and AST activities, which might be associated with the adaptation of organism to the introduced drugs. The decreased LDH activity in the blood serum of the rabbits during the administration of the preparations might be associated with enhanced intracellular metabolic processes requiring considerable expenditures of energy. The dynamics of the gamma glutamate transferase activity remained on the same level in the control and both experimental groups of female rabbits, indicating that the introduced copper nanoparticles drugs were not toxic. The administration of copper nanoparticles in the dose of 50 μg/kg of body weight has positive effects on the reproductive system of female rabbits and the processes of embryonic development.http://aminbiol.com.ua/index.php/archive/126-archive/bt-22-1-2020/1112-effects-of-copper-nanoparticles-on-the-biochemical-parameters-of-blood-serum-of-female-rabbitsrabbitscopper nanoparticlesenzymesimplantationcorpus luteumкролицінаночастинки купрумуензимиімплантаціяжовте тіло |
| spellingShingle | Yu. I. Slyvchuk O. V. Shtapenko I. I. Hevkan V. Y. Syrvatka O. Yu. Slyvchuk Effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbits Біологія тварин rabbits copper nanoparticles enzymes implantation corpus luteum кролиці наночастинки купруму ензими імплантація жовте тіло |
| title | Effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbits |
| title_full | Effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbits |
| title_fullStr | Effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbits |
| title_full_unstemmed | Effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbits |
| title_short | Effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbits |
| title_sort | effects of copper nanoparticles on the biochemical parameters of blood serum of female rabbits |
| topic | rabbits copper nanoparticles enzymes implantation corpus luteum кролиці наночастинки купруму ензими імплантація жовте тіло |
| url | http://aminbiol.com.ua/index.php/archive/126-archive/bt-22-1-2020/1112-effects-of-copper-nanoparticles-on-the-biochemical-parameters-of-blood-serum-of-female-rabbits |
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