Relationship between Virulence and Resistance among Gram-Negative Bacteria
Bacteria present in the human body are innocuous, providing beneficial functions, some of which are necessary for correct body function. However, other bacteria are able to colonize, invade, and cause damage to different tissues, and these are categorised as pathogens. These pathogenic bacteria poss...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/9/10/719 |
| _version_ | 1827703920671064064 |
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| author | Virginio Cepas Sara M. Soto |
| author_facet | Virginio Cepas Sara M. Soto |
| author_sort | Virginio Cepas |
| collection | DOAJ |
| description | Bacteria present in the human body are innocuous, providing beneficial functions, some of which are necessary for correct body function. However, other bacteria are able to colonize, invade, and cause damage to different tissues, and these are categorised as pathogens. These pathogenic bacteria possess several factors that enable them to be more virulent and cause infection. Bacteria have a great capacity to adapt to different niches and environmental conditions (presence of antibiotics, iron depletion, etc.). Antibiotic pressure has favoured the emergence and spread of antibiotic-resistant bacteria worldwide. Several studies have reported the presence of a relationship (both positive and negative, and both direct and indirect) between antimicrobial resistance and virulence among bacterial pathogens. This review studies the relationship among the most important Gram-negative bacteria (<i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>) taking into account two points of view: (i) the effect the acquisition of resistance has on virulence, and (ii) co-selection of resistance and virulence. The relationship between resistance and virulence among bacteria depends on the bacterial species, the specific mechanisms of resistance and virulence, the ecological niche, and the host. |
| first_indexed | 2024-03-10T15:28:37Z |
| format | Article |
| id | doaj.art-71efc731015b4e979d91285a8c6a763d |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T15:28:37Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-71efc731015b4e979d91285a8c6a763d2023-11-20T17:49:54ZengMDPI AGAntibiotics2079-63822020-10-0191071910.3390/antibiotics9100719Relationship between Virulence and Resistance among Gram-Negative BacteriaVirginio Cepas0Sara M. Soto1ISGlobal, Hospital Clínic—Universitat de Barcelona, 08036 Barcelona, SpainISGlobal, Hospital Clínic—Universitat de Barcelona, 08036 Barcelona, SpainBacteria present in the human body are innocuous, providing beneficial functions, some of which are necessary for correct body function. However, other bacteria are able to colonize, invade, and cause damage to different tissues, and these are categorised as pathogens. These pathogenic bacteria possess several factors that enable them to be more virulent and cause infection. Bacteria have a great capacity to adapt to different niches and environmental conditions (presence of antibiotics, iron depletion, etc.). Antibiotic pressure has favoured the emergence and spread of antibiotic-resistant bacteria worldwide. Several studies have reported the presence of a relationship (both positive and negative, and both direct and indirect) between antimicrobial resistance and virulence among bacterial pathogens. This review studies the relationship among the most important Gram-negative bacteria (<i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>) taking into account two points of view: (i) the effect the acquisition of resistance has on virulence, and (ii) co-selection of resistance and virulence. The relationship between resistance and virulence among bacteria depends on the bacterial species, the specific mechanisms of resistance and virulence, the ecological niche, and the host.https://www.mdpi.com/2079-6382/9/10/719antimicrobial resistancevirulencebiofilmsGram-negative: plasmids |
| spellingShingle | Virginio Cepas Sara M. Soto Relationship between Virulence and Resistance among Gram-Negative Bacteria Antibiotics antimicrobial resistance virulence biofilms Gram-negative: plasmids |
| title | Relationship between Virulence and Resistance among Gram-Negative Bacteria |
| title_full | Relationship between Virulence and Resistance among Gram-Negative Bacteria |
| title_fullStr | Relationship between Virulence and Resistance among Gram-Negative Bacteria |
| title_full_unstemmed | Relationship between Virulence and Resistance among Gram-Negative Bacteria |
| title_short | Relationship between Virulence and Resistance among Gram-Negative Bacteria |
| title_sort | relationship between virulence and resistance among gram negative bacteria |
| topic | antimicrobial resistance virulence biofilms Gram-negative: plasmids |
| url | https://www.mdpi.com/2079-6382/9/10/719 |
| work_keys_str_mv | AT virginiocepas relationshipbetweenvirulenceandresistanceamonggramnegativebacteria AT saramsoto relationshipbetweenvirulenceandresistanceamonggramnegativebacteria |