Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment
Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer’s Disease (AD). Prior research shows that females are more impacted by MCI than males. On average females have a greater incidence rate of any dementia and current evidence suggests that they suffer greater cognitive deterioration t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.959394/full |
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| author | Jordan Williamson Andriy Yabluchanskiy Peter Mukli Dee H. Wu Dee H. Wu Dee H. Wu Dee H. Wu William Sonntag Carrie Ciro Yuan Yang Yuan Yang Yuan Yang Yuan Yang Yuan Yang |
| author_facet | Jordan Williamson Andriy Yabluchanskiy Peter Mukli Dee H. Wu Dee H. Wu Dee H. Wu Dee H. Wu William Sonntag Carrie Ciro Yuan Yang Yuan Yang Yuan Yang Yuan Yang Yuan Yang |
| author_sort | Jordan Williamson |
| collection | DOAJ |
| description | Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer’s Disease (AD). Prior research shows that females are more impacted by MCI than males. On average females have a greater incidence rate of any dementia and current evidence suggests that they suffer greater cognitive deterioration than males in the same disease stage. Recent research has linked these sex differences to neuroimaging markers of brain pathology, such as hippocampal volumes. Specifically, the rate of hippocampal atrophy affects the progression of AD in females more than males. This study was designed to extend our understanding of the sex-related differences in the brain of participants with MCI. Specifically, we investigated the difference in the hippocampal connectivity to different areas of the brain. The Resting State fMRI and T2 MRI of cognitively normal individuals (n = 40, female = 20) and individuals with MCI (n = 40, female = 20) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed using the Functional Connectivity Toolbox (CONN). Our results demonstrate that connectivity of hippocampus to the precuneus cortex and brain stem was significantly stronger in males than in females. These results improve our current understanding of the role of hippocampus-precuneus cortex and hippocampus-brainstem connectivity in sex differences in MCI. Understanding the contribution of impaired functional connectivity sex differences may aid in the development of sex specific precision medicine to manipulate hippocampal-precuneus cortex and hippocampal-brainstem connectivity to decrease the progression of MCI to AD. |
| first_indexed | 2024-04-13T18:58:22Z |
| format | Article |
| id | doaj.art-71efcb3a39994c19812a6b9e7e47e561 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T18:58:22Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-71efcb3a39994c19812a6b9e7e47e5612022-12-22T02:34:10ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.959394959394Sex differences in brain functional connectivity of hippocampus in mild cognitive impairmentJordan Williamson0Andriy Yabluchanskiy1Peter Mukli2Dee H. Wu3Dee H. Wu4Dee H. Wu5Dee H. Wu6William Sonntag7Carrie Ciro8Yuan Yang9Yuan Yang10Yuan Yang11Yuan Yang12Yuan Yang13Neural Control and Rehabilitation Laboratory, Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartment of Radiological Science and Medical Physics, University of Oklahoma Health Science Center, Oklahoma City, OK, United StatesData Institute for Societal Challenges, University of Oklahoma, Norman, OK, United StatesSchool of Computer Science, Gallogly College of Engineering, University of Oklahoma, Norman, OK, United StatesSchool of Electrical and Computer Engineering, Gallogly College of Engineering, University of Oklahoma, Norman, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartment of Rehabilitation Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, United StatesNeural Control and Rehabilitation Laboratory, Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United StatesData Institute for Societal Challenges, University of Oklahoma, Norman, OK, United StatesDepartment of Rehabilitation Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, United StatesSchool of Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United StatesDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United StatesMild cognitive impairment (MCI) is the prodromal stage of Alzheimer’s Disease (AD). Prior research shows that females are more impacted by MCI than males. On average females have a greater incidence rate of any dementia and current evidence suggests that they suffer greater cognitive deterioration than males in the same disease stage. Recent research has linked these sex differences to neuroimaging markers of brain pathology, such as hippocampal volumes. Specifically, the rate of hippocampal atrophy affects the progression of AD in females more than males. This study was designed to extend our understanding of the sex-related differences in the brain of participants with MCI. Specifically, we investigated the difference in the hippocampal connectivity to different areas of the brain. The Resting State fMRI and T2 MRI of cognitively normal individuals (n = 40, female = 20) and individuals with MCI (n = 40, female = 20) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed using the Functional Connectivity Toolbox (CONN). Our results demonstrate that connectivity of hippocampus to the precuneus cortex and brain stem was significantly stronger in males than in females. These results improve our current understanding of the role of hippocampus-precuneus cortex and hippocampus-brainstem connectivity in sex differences in MCI. Understanding the contribution of impaired functional connectivity sex differences may aid in the development of sex specific precision medicine to manipulate hippocampal-precuneus cortex and hippocampal-brainstem connectivity to decrease the progression of MCI to AD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.959394/fullmild cognitive impairmentsex differencehippocampusfunctional connectivityAlzheimer’s disease |
| spellingShingle | Jordan Williamson Andriy Yabluchanskiy Peter Mukli Dee H. Wu Dee H. Wu Dee H. Wu Dee H. Wu William Sonntag Carrie Ciro Yuan Yang Yuan Yang Yuan Yang Yuan Yang Yuan Yang Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment Frontiers in Aging Neuroscience mild cognitive impairment sex difference hippocampus functional connectivity Alzheimer’s disease |
| title | Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment |
| title_full | Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment |
| title_fullStr | Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment |
| title_full_unstemmed | Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment |
| title_short | Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment |
| title_sort | sex differences in brain functional connectivity of hippocampus in mild cognitive impairment |
| topic | mild cognitive impairment sex difference hippocampus functional connectivity Alzheimer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.959394/full |
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