Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study
Objective: This study aimed to determine the range of weight loss, at 3 days postnatal age, associated with the lowest risk of mortality/short-term morbidity in preterm infants <29 weeks gestational age (GA). Study design: This multicenter retrospective cohort study employed data from the Canadia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/2/276 |
| _version_ | 1797481629175775232 |
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| author | Carlos Zozaya Khalid Aziz Nalini Singhal Xiang Y. Ye Christine Drolet Julie Emberley Kyong-Soon Lee Vibhuti S. Shah on behalf of the Canadian Neonatal Network (CNN) Investigators |
| author_facet | Carlos Zozaya Khalid Aziz Nalini Singhal Xiang Y. Ye Christine Drolet Julie Emberley Kyong-Soon Lee Vibhuti S. Shah on behalf of the Canadian Neonatal Network (CNN) Investigators |
| author_sort | Carlos Zozaya |
| collection | DOAJ |
| description | Objective: This study aimed to determine the range of weight loss, at 3 days postnatal age, associated with the lowest risk of mortality/short-term morbidity in preterm infants <29 weeks gestational age (GA). Study design: This multicenter retrospective cohort study employed data from the Canadian Neonatal Network database. The primary outcome was a composite of mortality and/or severe neurological injury. Multivariable quadratic and linear regression models which adjusted for potential confounders were built. Results: A total of 9275 preterm infants (median GA 26, IQR 25, 28 weeks) were included. The optimal weight change range at day three, after adjustment for potential confounders for the primary outcomes, was −15 to −8.9%. Conclusions: There is a ‘U’-shaped relationship between weight change from birth to day three and mortality and/or severe neurological injury. Interventional studies, which target weight loss within the range found in this study and evaluate the impact on neonatal outcomes, are needed to corroborate our findings. |
| first_indexed | 2024-03-09T22:17:18Z |
| format | Article |
| id | doaj.art-71efe8223c3c49d8b5aedbbc4b330aa3 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T22:17:18Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-71efe8223c3c49d8b5aedbbc4b330aa32023-11-23T19:20:23ZengMDPI AGChildren2227-90672022-02-019227610.3390/children9020276Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort StudyCarlos Zozaya0Khalid Aziz1Nalini Singhal2Xiang Y. Ye3Christine Drolet4Julie Emberley5Kyong-Soon Lee6Vibhuti S. Shah7on behalf of the Canadian Neonatal Network (CNN) InvestigatorsDepartment of Paediatrics, Mount Sinai Hospital, Toronto, ON M5G 1X5, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, CanadaDepartment of Pediatrics, University of Calgary, Calgary, AB T2N 1N4, CanadaMaternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital, Toronto, ON M5G 1X6, CanadaCentre Mère-Enfant Soleil, Centre Hospitalier Universitaire de Québec, Université Laval, Quebec City, QC G1V 4G2, CanadaDepartment of Pediatrics, Janeway Children’s Health and Rehabilitation Center, Memorial University of Newfoundland, St. John’s, NL A1B 3V6, CanadaDivision of Neonatology, The Hospital for Sick Children, Toronto, ON M5G 1X8, CanadaDepartment of Paediatrics, Mount Sinai Hospital, Toronto, ON M5G 1X5, CanadaObjective: This study aimed to determine the range of weight loss, at 3 days postnatal age, associated with the lowest risk of mortality/short-term morbidity in preterm infants <29 weeks gestational age (GA). Study design: This multicenter retrospective cohort study employed data from the Canadian Neonatal Network database. The primary outcome was a composite of mortality and/or severe neurological injury. Multivariable quadratic and linear regression models which adjusted for potential confounders were built. Results: A total of 9275 preterm infants (median GA 26, IQR 25, 28 weeks) were included. The optimal weight change range at day three, after adjustment for potential confounders for the primary outcomes, was −15 to −8.9%. Conclusions: There is a ‘U’-shaped relationship between weight change from birth to day three and mortality and/or severe neurological injury. Interventional studies, which target weight loss within the range found in this study and evaluate the impact on neonatal outcomes, are needed to corroborate our findings.https://www.mdpi.com/2227-9067/9/2/276preterm-infantweightmortalityneurological injury |
| spellingShingle | Carlos Zozaya Khalid Aziz Nalini Singhal Xiang Y. Ye Christine Drolet Julie Emberley Kyong-Soon Lee Vibhuti S. Shah on behalf of the Canadian Neonatal Network (CNN) Investigators Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study Children preterm-infant weight mortality neurological injury |
| title | Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study |
| title_full | Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study |
| title_fullStr | Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study |
| title_full_unstemmed | Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study |
| title_short | Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study |
| title_sort | association of weight changes by three days after birth and mortality and or severe neurological injury in preterm infants 29 weeks gestational age a multicenter cohort study |
| topic | preterm-infant weight mortality neurological injury |
| url | https://www.mdpi.com/2227-9067/9/2/276 |
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