Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis
Classical (CKp) and hypervirulent (hvKp) Klebsiella pneumoniae are two different circulating pathotypes. The aim of this study was to assess the prevalence, epidemiology and molecular relatedness of hvKps using a systemic review and meta-analysis. The data extracted from Medline, Embase, and Web of...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-06-01
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| Series: | Iranian Journal of Microbiology |
| Subjects: | |
| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/2705 |
| _version_ | 1818603324827500544 |
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| author | Rahimeh Sanikhani Mohammad Moeinirad Fereshteh Shahcheraghi Arezou Lari Sepideh Fereshteh Amin Sepehr Afsaneh Salimi Farzad Badmasti |
| author_facet | Rahimeh Sanikhani Mohammad Moeinirad Fereshteh Shahcheraghi Arezou Lari Sepideh Fereshteh Amin Sepehr Afsaneh Salimi Farzad Badmasti |
| author_sort | Rahimeh Sanikhani |
| collection | DOAJ |
| description | Classical (CKp) and hypervirulent (hvKp) Klebsiella pneumoniae are two different circulating pathotypes. The aim of this study was to assess the prevalence, epidemiology and molecular relatedness of hvKps using a systemic review and meta-analysis. The data extracted from Medline, Embase, and Web of Science and finally 14 studies met the eligible criteria. To combine prevalence proportions of all studies, we performed the metaprop command embedded in the Meta package software. Totally, of 1814 K. pneumoniae isolates, 21.7% (394/1814) were hvKp. The molecular typing showed that all hvKp isolates were grouped into 50 different sequence types (STs) of them ST23, ST11, ST65 and ST86 were common. K1, K2 and K64 were dominant capsule serotypes that strongly related to ST23, ST65 and ST11, respectively. It seems that clonal group 23 (CG23) is associated with liver abscess and CG11 related to various clinical sources. |
| first_indexed | 2024-12-16T13:21:22Z |
| format | Article |
| id | doaj.art-71f0bb30c3f54d6fae03659511ca414c |
| institution | Directory Open Access Journal |
| issn | 2008-3289 2008-4447 |
| language | English |
| last_indexed | 2024-12-16T13:21:22Z |
| publishDate | 2021-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj.art-71f0bb30c3f54d6fae03659511ca414c2022-12-21T22:30:20ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472021-06-011332572652705Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysisRahimeh Sanikhani0Mohammad Moeinirad1Fereshteh Shahcheraghi2Arezou Lari3Sepideh Fereshteh4Amin Sepehr5Afsaneh Salimi6Farzad Badmasti7Department of Bacteriology, Pasteur Institute of Iran, Tehran, IranDepartment of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Bacteriology, Pasteur Institute of Iran, Tehran, IranDepartment of Systems Biomedicine, Pasteur Institute of Iran, Tehran, IranDepartment of Bacteriology, Pasteur Institute of Iran, Tehran, IranDepartment of Bacteriology, Pasteur Institute of Iran, Tehran, IranDepartment of Bacteriology, Pasteur Institute of Iran, Tehran, IranDepartment of Bacteriology, Pasteur Institute of Iran, Tehran, IranClassical (CKp) and hypervirulent (hvKp) Klebsiella pneumoniae are two different circulating pathotypes. The aim of this study was to assess the prevalence, epidemiology and molecular relatedness of hvKps using a systemic review and meta-analysis. The data extracted from Medline, Embase, and Web of Science and finally 14 studies met the eligible criteria. To combine prevalence proportions of all studies, we performed the metaprop command embedded in the Meta package software. Totally, of 1814 K. pneumoniae isolates, 21.7% (394/1814) were hvKp. The molecular typing showed that all hvKp isolates were grouped into 50 different sequence types (STs) of them ST23, ST11, ST65 and ST86 were common. K1, K2 and K64 were dominant capsule serotypes that strongly related to ST23, ST65 and ST11, respectively. It seems that clonal group 23 (CG23) is associated with liver abscess and CG11 related to various clinical sources.https://ijm.tums.ac.ir/index.php/ijm/article/view/2705hypervirulent klebsiella pneumonia;virulence factors;molecular typing;pathotypesi genotypes |
| spellingShingle | Rahimeh Sanikhani Mohammad Moeinirad Fereshteh Shahcheraghi Arezou Lari Sepideh Fereshteh Amin Sepehr Afsaneh Salimi Farzad Badmasti Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis Iranian Journal of Microbiology hypervirulent klebsiella pneumonia; virulence factors; molecular typing; pathotypesi genotypes |
| title | Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis |
| title_full | Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis |
| title_fullStr | Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis |
| title_full_unstemmed | Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis |
| title_short | Molecular epidemiology of hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis |
| title_sort | molecular epidemiology of hypervirulent klebsiella pneumoniae a systematic review and meta analysis |
| topic | hypervirulent klebsiella pneumonia; virulence factors; molecular typing; pathotypesi genotypes |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/2705 |
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