Hypothermia and heart rate variability in a healthy newborn piglet model
Abstract Decreased heart rate variability (HRV) may be a biomarker of brain injury severity in neonatal hypoxic-ischemic encephalopathy for which therapeutic hypothermia is standard treatment. While therapeutic hypothermia may influence the degree of brain injury; hypothermia may also affect HRV per...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22426-3 |
| _version_ | 1811328531382140928 |
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| author | Mette Vestergård Pedersen Ted Carl Kejlberg Andelius Hannah Brogård Andersen Kasper Jacobsen Kyng Tine Brink Henriksen |
| author_facet | Mette Vestergård Pedersen Ted Carl Kejlberg Andelius Hannah Brogård Andersen Kasper Jacobsen Kyng Tine Brink Henriksen |
| author_sort | Mette Vestergård Pedersen |
| collection | DOAJ |
| description | Abstract Decreased heart rate variability (HRV) may be a biomarker of brain injury severity in neonatal hypoxic-ischemic encephalopathy for which therapeutic hypothermia is standard treatment. While therapeutic hypothermia may influence the degree of brain injury; hypothermia may also affect HRV per se and obscure a potential association between HRV and hypoxic-ischemic encephalopathy. Previous results are conflicting. This study aimed to investigate the effect of hypothermia on HRV in healthy, anaesthetised, newborn piglets. Six healthy newborn piglets were anaesthetised. Three piglets were first kept normothermic (38.5–39.0 °C) for 3 h, then exposed to hypothermia (33.5–34.5 °C) for 3 h. Three piglets were first exposed to hypothermia for 3 h, then rewarmed to normothermia for 3 h. Temperature and ECG were recorded continuously. HRV was calculated from the ECG in 5 min epochs and included time domain and frequency domain variables. The HRV variables were compared between hypothermia and normothermia. All assessed HRV variables were higher during hypothermia compared to normothermia. Heart rate was lower during hypothermia compared to normothermia and all HRV variables correlated with heart rate. Hypothermia was associated with an increase in HRV; this could be mediated by bradycardia during hypothermia. |
| first_indexed | 2024-04-13T15:26:49Z |
| format | Article |
| id | doaj.art-71f2a625af8f41f180ab038020718e3c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T15:26:49Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-71f2a625af8f41f180ab038020718e3c2022-12-22T02:41:29ZengNature PortfolioScientific Reports2045-23222022-10-011211910.1038/s41598-022-22426-3Hypothermia and heart rate variability in a healthy newborn piglet modelMette Vestergård Pedersen0Ted Carl Kejlberg Andelius1Hannah Brogård Andersen2Kasper Jacobsen Kyng3Tine Brink Henriksen4Department of Pediatrics, Aarhus University HospitalDepartment of Pediatrics, Aarhus University HospitalDepartment of Pediatrics, Aarhus University HospitalDepartment of Pediatrics, Aarhus University HospitalDepartment of Pediatrics, Aarhus University HospitalAbstract Decreased heart rate variability (HRV) may be a biomarker of brain injury severity in neonatal hypoxic-ischemic encephalopathy for which therapeutic hypothermia is standard treatment. While therapeutic hypothermia may influence the degree of brain injury; hypothermia may also affect HRV per se and obscure a potential association between HRV and hypoxic-ischemic encephalopathy. Previous results are conflicting. This study aimed to investigate the effect of hypothermia on HRV in healthy, anaesthetised, newborn piglets. Six healthy newborn piglets were anaesthetised. Three piglets were first kept normothermic (38.5–39.0 °C) for 3 h, then exposed to hypothermia (33.5–34.5 °C) for 3 h. Three piglets were first exposed to hypothermia for 3 h, then rewarmed to normothermia for 3 h. Temperature and ECG were recorded continuously. HRV was calculated from the ECG in 5 min epochs and included time domain and frequency domain variables. The HRV variables were compared between hypothermia and normothermia. All assessed HRV variables were higher during hypothermia compared to normothermia. Heart rate was lower during hypothermia compared to normothermia and all HRV variables correlated with heart rate. Hypothermia was associated with an increase in HRV; this could be mediated by bradycardia during hypothermia.https://doi.org/10.1038/s41598-022-22426-3 |
| spellingShingle | Mette Vestergård Pedersen Ted Carl Kejlberg Andelius Hannah Brogård Andersen Kasper Jacobsen Kyng Tine Brink Henriksen Hypothermia and heart rate variability in a healthy newborn piglet model Scientific Reports |
| title | Hypothermia and heart rate variability in a healthy newborn piglet model |
| title_full | Hypothermia and heart rate variability in a healthy newborn piglet model |
| title_fullStr | Hypothermia and heart rate variability in a healthy newborn piglet model |
| title_full_unstemmed | Hypothermia and heart rate variability in a healthy newborn piglet model |
| title_short | Hypothermia and heart rate variability in a healthy newborn piglet model |
| title_sort | hypothermia and heart rate variability in a healthy newborn piglet model |
| url | https://doi.org/10.1038/s41598-022-22426-3 |
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