Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions

Confocal laser endomicroscopy (CLE) is a new technology enabling endoscopists to visualize tissue at the cellular level. CLE has the fundamental potential to provide a histologic diagnosis, and may theoretically replace or reduce the need for performing biopsy for histology. The clinical benefits of...

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Main Author: Sang Kil Lee
Format: Article
Language:English
Published: Korean Society of Gastrointestinal Endoscopy 2015-11-01
Series:Clinical Endoscopy
Subjects:
Online Access:http://www.e-ce.org/upload/pdf/ce-48-6-511.pdf
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author Sang Kil Lee
author_facet Sang Kil Lee
author_sort Sang Kil Lee
collection DOAJ
description Confocal laser endomicroscopy (CLE) is a new technology enabling endoscopists to visualize tissue at the cellular level. CLE has the fundamental potential to provide a histologic diagnosis, and may theoretically replace or reduce the need for performing biopsy for histology. The clinical benefits of CLE are more obvious in esophageal disease, including Barrett’s esophagus. Currently, this technology has been adapted to the diagnosis and surveillance of Barrett’s esophagus and related neoplasia. Standard white light endoscopy is the primary tool for gastric cancer screening. Currently, the only method available to precisely diagnose these lesions is upper endoscopy with an appropriate biopsy. A recent study showed that CLE could characterize dysplasia or cancer and identify the risk factors for gastric cancer, such as intestinal metaplasia and the presence of Helicobacter pylori in vivo, although fewer studies on CLE were performed on the stomach than on Barrett’s esophagus and other esophageal diseases. However, the application of CLE to routine clinical endoscopy continues to be refined. This review focused on the usefulness and future prospects of CLE for gastric premalignant and malignant lesions.
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spelling doaj.art-71f5b1b65de544f9bd8dfac1520331112023-12-02T22:06:50ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432015-11-0148651151510.5946/ce.2015.48.6.5116794Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant LesionsSang Kil LeeConfocal laser endomicroscopy (CLE) is a new technology enabling endoscopists to visualize tissue at the cellular level. CLE has the fundamental potential to provide a histologic diagnosis, and may theoretically replace or reduce the need for performing biopsy for histology. The clinical benefits of CLE are more obvious in esophageal disease, including Barrett’s esophagus. Currently, this technology has been adapted to the diagnosis and surveillance of Barrett’s esophagus and related neoplasia. Standard white light endoscopy is the primary tool for gastric cancer screening. Currently, the only method available to precisely diagnose these lesions is upper endoscopy with an appropriate biopsy. A recent study showed that CLE could characterize dysplasia or cancer and identify the risk factors for gastric cancer, such as intestinal metaplasia and the presence of Helicobacter pylori in vivo, although fewer studies on CLE were performed on the stomach than on Barrett’s esophagus and other esophageal diseases. However, the application of CLE to routine clinical endoscopy continues to be refined. This review focused on the usefulness and future prospects of CLE for gastric premalignant and malignant lesions.http://www.e-ce.org/upload/pdf/ce-48-6-511.pdfConfocal laser endomicroscopyStomach neoplasmsGastric intestinal metaplasia
spellingShingle Sang Kil Lee
Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions
Clinical Endoscopy
Confocal laser endomicroscopy
Stomach neoplasms
Gastric intestinal metaplasia
title Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions
title_full Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions
title_fullStr Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions
title_full_unstemmed Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions
title_short Usefulness and Future Prospects of Confocal Laser Endomicroscopy for Gastric Premalignant and Malignant Lesions
title_sort usefulness and future prospects of confocal laser endomicroscopy for gastric premalignant and malignant lesions
topic Confocal laser endomicroscopy
Stomach neoplasms
Gastric intestinal metaplasia
url http://www.e-ce.org/upload/pdf/ce-48-6-511.pdf
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