Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors
Proton minibeam radiation therapy (pMBRT) is a novel cancer therapy approach based on a high spatial dose modulation. pMBRT activates distinct radiobiological mechanisms and it has been shown to lead in small animal experiments to a significant increase in normal tissue dose tolerances while maintai...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2021-12-01
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| Series: | Comptes Rendus Biologies |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.71/ |
| _version_ | 1797651248229384192 |
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| author | Prezado, Yolanda |
| author_facet | Prezado, Yolanda |
| author_sort | Prezado, Yolanda |
| collection | DOAJ |
| description | Proton minibeam radiation therapy (pMBRT) is a novel cancer therapy approach based on a high spatial dose modulation. pMBRT activates distinct radiobiological mechanisms and it has been shown to lead in small animal experiments to a significant increase in normal tissue dose tolerances while maintaining or enhancing tumor control effectiveness as compared with conventional radiotherapy. Although recently proposed, the biological observations collected thus far challenge the classical paradigm in RT and encourage the preparation of phase I clinical trials. |
| first_indexed | 2024-03-11T16:13:11Z |
| format | Article |
| id | doaj.art-71f630a7bfe34e709eecbec7217f8dc4 |
| institution | Directory Open Access Journal |
| issn | 1768-3238 |
| language | English |
| last_indexed | 2024-03-11T16:13:11Z |
| publishDate | 2021-12-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj.art-71f630a7bfe34e709eecbec7217f8dc42023-10-24T14:25:23ZengAcadémie des sciencesComptes Rendus Biologies1768-32382021-12-01344440942010.5802/crbiol.7110.5802/crbiol.71Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumorsPrezado, Yolanda0https://orcid.org/0000-0001-5957-2327Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et cancer, 91400 Orsay, France; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et cancer, 91400 Orsay, FranceProton minibeam radiation therapy (pMBRT) is a novel cancer therapy approach based on a high spatial dose modulation. pMBRT activates distinct radiobiological mechanisms and it has been shown to lead in small animal experiments to a significant increase in normal tissue dose tolerances while maintaining or enhancing tumor control effectiveness as compared with conventional radiotherapy. Although recently proposed, the biological observations collected thus far challenge the classical paradigm in RT and encourage the preparation of phase I clinical trials.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.71/Proton minibeam radiation therapyBrain tumorsRadioresistant tumorsNormal tissue tolerancesInnovative radiotherapyProton therapy |
| spellingShingle | Prezado, Yolanda Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors Comptes Rendus Biologies Proton minibeam radiation therapy Brain tumors Radioresistant tumors Normal tissue tolerances Innovative radiotherapy Proton therapy |
| title | Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors |
| title_full | Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors |
| title_fullStr | Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors |
| title_full_unstemmed | Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors |
| title_short | Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors |
| title_sort | proton minibeam radiation therapy a promising therapeutic approach for radioresistant tumors |
| topic | Proton minibeam radiation therapy Brain tumors Radioresistant tumors Normal tissue tolerances Innovative radiotherapy Proton therapy |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.71/ |
| work_keys_str_mv | AT prezadoyolanda protonminibeamradiationtherapyapromisingtherapeuticapproachforradioresistanttumors |